SXRrs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome

2016 ◽  
Vol 17 (11) ◽  
pp. 1227-1233 ◽  
Author(s):  
Stefano Turolo ◽  
Alberto Edefonti ◽  
Marta Lepore ◽  
Luciana Ghio ◽  
Eva Cuzzoni ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Prognostic Factor ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Sensitivity

Time for Initial Response to Steroids Is a Major Prognostic Factor in Idiopathic Nephrotic Syndrome

2010 ◽  
Vol 156 (6) ◽  
pp. 965-971 ◽  
Author(s):  
Marina Vivarelli ◽  
Eleonora Moscaritolo ◽  
Aggelos Tsalkidis ◽  
Laura Massella ◽  
Francesco Emma
Keyword(s):  
Nephrotic Syndrome ◽  
Prognostic Factor ◽  
Idiopathic Nephrotic Syndrome ◽  
Initial Response ◽  
Major Prognostic Factor

scholarly journals Glucocorticoid receptors, in vitro steroid sensitivity, and cytokine secretion in idiopathic nephrotic syndrome

2004 ◽  
Vol 65 (2) ◽  
pp. 403-408 ◽  
Author(s):  
Ana Paula de Carvalho ◽  
Panzeri Carlotti ◽  
Paulo Benedito Franco ◽  
Lucila Leico Elias ◽  
Inalda Facincani ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Glucocorticoid Receptors ◽  
Idiopathic Nephrotic Syndrome ◽  
Cytokine Secretion ◽  
Steroid Sensitivity

scholarly journals High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Taiwo Augustina Ladapo ◽  
Christopher Imokhuede Esezobor ◽  
Foluso Ebun Lesi
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Black Children ◽  
Response To Treatment ◽  
Southwestern Nigeria ◽  
Childhood Nephrotic Syndrome ◽  
Sensitivity Pattern ◽  
Renal Histology ◽  
Steroid Sensitivity ◽  
Black Populations

Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including age, response to treatment, and renal histology were analysed. There were 108 children (median age: 5.9 years, peak: 1-2 years), 90.2% of whom had idiopathic nephrotic syndrome. Steroid sensitivity was 82.8% among children with idiopathic nephrotic syndrome but 75.9% overall. Median time to remission was 7 days. Median age was significantly lower in steroid sensitive compared with resistant patients. The predominant histologic finding in resistant cases was focal segmental glomerulosclerosis (53.3%). No cases of quartan malaria nephropathy or hepatitis B virus nephropathy were diagnosed. Overall mortality was 6.5%. In conclusion, unusually high steroid sensitivity is reported among a cohort of black children. This is likely attributable to the lower age structure of our cohort as well as possible changing epidemiology of some other childhood diseases. Surveillance of the epidemiology of childhood nephrotic syndrome and corresponding modifications in practice are therefore recommended.

scholarly journals NGAL distinguishes steroid sensitivity in idiopathic nephrotic syndrome

2011 ◽  
Vol 27 (5) ◽  
pp. 807-812 ◽  
Author(s):  
Michael R. Bennett ◽  
Nuntawan Piyaphanee ◽  
Kimberly Czech ◽  
Mark Mitsnefes ◽  
Prasad Devarajan
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Sensitivity

RNA expression as a prognostic tool in idiopathic nephrotic syndrome

2007 ◽  
Vol 148 (23) ◽  
pp. 1067-1075
Author(s):  
Krisztina Fischer ◽  
Orsolya Galamb ◽  
Béla Molnár ◽  
Zsolt Tulassay ◽  
András Szabó
Keyword(s):  
Nephrotic Syndrome ◽  
Northern Blot ◽  
Idiopathic Nephrotic Syndrome ◽  
Minimal Change ◽  
Ribonuclease Protection Assay ◽  
Rna Expression ◽  
Rt Pcr ◽  
Protection Assay ◽  
Ribonuclease Protection

A gyermekkori nephrosis 90%-a idiopathiás nephrosis szindróma. Az idetartozó három kórkép, a minimal change betegség, a mesangialis proliferatio és a focalis sclerosis hasonló klinikai képpel jelentkező, eltérő prognózisú és terápiás válaszú betegség. Dolgozatunk célja az idiopathiás nephrosis szindrómába tartozó kórképek kialakulásával, progressziójával összefüggő genetikai ismeretek, génexpressziós változások áttekintése és funkcionális csoportosítása. A génexpressziós változások meghatározásának eszközeként, dolgozatunk röviden összefoglalja a northern blot, a ribonuclease protection assay, az in situ RNS-hibridizáció, a kvantitatív RT-PCR és a microarray módszerek lényegét. Az eddig elvégzett vizsgálatok a DNS-szintézis és repair gének, növekedési faktorok, extracelluláris mátrix, extracelluláris ligandreceptorok, extracelluláris jelátvitel zavarai mellett kiemelik a metabolikus és transzporter gének, illetve az immunszabályozó gének molekuláris eltéréseit, amelyek összefüggésben vannak az idiopathiás nephrosis szindróma eddig megismert molekuláris hátterével. A chiptechnológia fejlődésével és elterjedésével ezek a markerek és a hagyományos vizsgálati módszerek párhuzamos alkalmazása rutindiagnosztikai szempontból is fontossá válhat.

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