Toward an optimized treatment of intracellular bacterial infections: input of nanoparticulate drug delivery systems

Nanomedicine ◽  
2015 ◽  
Vol 10 (19) ◽  
pp. 3033-3055 ◽  
Author(s):  
Catherine Ladavière ◽  
Ruxandra Gref
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Optimized Treatment

scholarly journals A REVIEW ON CIPROFLOXACIN: DOSAGE FORM PERSPECTIVE

2018 ◽  
Vol 10 (4) ◽  
pp. 6 ◽  
Author(s):  
M. Vidyavathi ◽  
G. Srividya
Keyword(s):  
Drug Delivery ◽  
Mechanism Of Action ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Research Work ◽  
Delivery Systems ◽  
Drug Reactions ◽  
Methods Development ◽  
Pure Drug

Ciprofloxacin (CF) is one of the topmost selling antibiotics and it is available at a cheap cost which is used to treat many bacterial infections. Many research scientists are working on this drug for various applications on different drug delivery systems. The main objective of this paper is to enlighten about the details of pure drug CF and its delivery systems along with current research on this drug. This review focused on history, pharmacokinetics, mechanism of action, types of dosage form available in the market with their cost, current research going on this drug with their applications and methods development for estimation of CF. It also highlighted the possible interactions and adverse drug reactions of CF and patents available. The present review revealed that the only analytical method for estimation of CF was developed in the first decade, few drug delivery systems (DDS) of CF were developed in the second decade and more research work on the development of novel DDS of CF founded in the last decade.

scholarly journals Engineered Remolding and Application of Bacterial Membrane Vesicles

2021 ◽  
Vol 12 ◽  
Author(s):  
Li Qiao ◽  
Yifan Rao ◽  
Keting Zhu ◽  
Xiancai Rao ◽  
Renjie Zhou
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Membrane Vesicles ◽  
Delivery Systems ◽  
Bacterial Membrane ◽  
Wild Type ◽  
Bacterial Strains

Bacterial membrane vesicles (MVs) are produced by both Gram-positive and Gram-negative bacteria during growth in vitro and in vivo. MVs are nanoscale vesicular structures with diameters ranging from 20 to 400 nm. MVs incorporate bacterial lipids, proteins, and often nucleic acids, and can effectively stimulate host immune response against bacterial infections. As vaccine candidates and drug delivery systems, MVs possess high biosafety owing to the lack of self-replication ability. However, wild-type bacterial strains have poor MV yield, and MVs from the wild-type strains may be harmful due to the carriage of toxic components, such as lipopolysaccharides, hemolysins, enzymes, etc. In this review, we summarize the genetic modification of vesicle-producing bacteria to reduce MV toxicity, enhance vesicle immunogenicity, and increase vesicle production. The engineered MVs exhibit broad applications in vaccine designs, vaccine delivery vesicles, and drug delivery systems.

Glucosylated liposomes as drug delivery systems of usnic acid to address bacterial infections

2019 ◽  
Vol 181 ◽  
pp. 632-638 ◽  
Author(s):  
Iolanda Francolini ◽  
Luisa Giansanti ◽  
Antonella Piozzi ◽  
Barbara Altieri ◽  
Alessandro Mauceri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Usnic Acid ◽  
Delivery Systems

scholarly journals Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1052
Author(s):  
Reem Abou Assi ◽  
Ibrahim M. Abdulbaqi ◽  
Toh Seok Ming ◽  
Chan Siok Yee ◽  
Habibah A. Wahab ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Storage Conditions ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
In Vitro Characterization ◽  
Low Solubility

Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial infections. The drug is known to have low oral bioavailability (37%) which may be attributed to its relatively high molecular weight, low solubility, dissolution rate, and incomplete intestinal absorption. To overcome these drawbacks, liquid (L) and solid (S) self-emulsifying drug delivery systems (SEDDs) of AZM were developed and optimized. Eight different pseudo-ternary diagrams were constructed based on the drug solubility and the emulsification studies in various SEDDs excipients at different surfactant to co-surfactant (Smix) ratios. Droplet size (DS) < 150 nm, dispersity (Đ) ≤ 0.7, and transmittance (T)% > 85 in three diluents of distilled water (DW), 0.1 mM HCl, and simulated intestinal fluids (SIF) were considered as the selection criteria. The final formulations of L-SEDDs (L-F1(H)), and S-SEDDs (S-F1(H)) were able to meet the selection requirements. Both formulations were proven to be cytocompatible and able to open up the cellular epithelial tight junctions (TJ). The drug dissolution studies showed that after 5 min > 90% and 52.22% of the AZM was released from liquid and solid SEDDs formulations in DW, respectively, compared to 11.27% of the pure AZM, suggesting the developed SEDDs may enhance the oral delivery of the drug. The formulations were stable at refrigerator storage conditions.

Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

2020 ◽  
Vol 26 (36) ◽  
pp. 4569-4579 ◽  
Author(s):  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Srividya Gorantla ◽  
Ranendra Narayan Saha ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Skin Permeation ◽  
Clinical Status ◽  
Age Groups ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Skin Disorders

Background: Skin diseases affect all the age groups of people and have an impact on patients’ physical, mental, and emotional status. Conventional topical preparation is limited with its efficacy due to low permeation, frequent application, and poor adherence to the therapy for prolong time. Objective: The objective of this review article is to address the emerging trends of nanotechnology derived lipidic carrier systems for an effective treatment for skin disorders. Methodology: Various research and review articles from reputed international journals were referred and compiled. Results and Discussion: opical drug delivery systems were found to be more effective than oral and parenteral drug delivery systems for treating skin diseases due to targeted localized applications with reduced side effects. Lipid-based nanoparticles have been found to have the potential in treating skin diseases due to the biocompatibility and the versatility of the lipids. Nanostructured lipid carriers (NLCs) have gained much attention in treating skin diseases due to improved stability of the drugs, enhanced skin permeation, retention, and better therapeutic efficacy. The review summarizes the NLCs characteristics and their application for topical delivery of various therapeutics in skin disorders. NLCs have shown great potential in effective drug delivery for the treatment of psoriasis, dermatitis, bacterial infections, and skin cancer. Its cosmetic application has opened a new area for skincare. Furthermore, safety and clinical status revealed its future commercial acceptability. Conclusion: NLCs have been found as effective lipid nanocarriers for the delivery of topical therapeutics.

scholarly journals Biomimetic Bacterial Membrane Vesicles for Drug Delivery Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1430
Author(s):  
Sajid Fazal ◽  
Ruda Lee
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Mammalian Cells ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Scale Up ◽  
Membrane Vesicles ◽  
Delivery Systems ◽  
Bacterial Membrane

Numerous factors need to be considered to develop a nanodrug delivery system that is biocompatible, non-toxic, easy to synthesize, cost-effective, and feasible for scale up over and above their therapeutic efficacy. With regards to this, worldwide, exosomes, which are nano-sized vesicles obtained from mammalian cells, are being explored as a biomimetic drug delivery system that has superior biocompatibility and high translational capability. However, the economics of undertaking large-scale mammalian culture to derive exosomal vesicles for translation seems to be challenging and unfeasible. Recently, Bacterial Membrane Vesicles (BMVs) derived from bacteria are being explored as a viable alternative as biomimetic drug delivery systems that can be manufactured relatively easily at much lower costs at a large scale. Until now, BMVs have been investigated extensively as successful immunomodulating agents, but their capability as drug delivery systems remains to be explored in detail. In this review, the use of BMVs as suitable cargo delivery vehicles is discussed with focus on their use for in vivo treatment of cancer and bacterial infections reported thus far. Additionally, the different types of BMVs, factors affecting their synthesis and different cargo loading techniques used in BMVs are also discussed.

scholarly journals Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 47
Author(s):  
Xiao Ma ◽  
Yun Gao ◽  
Duoyi Zhao ◽  
Weilin Zhang ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Molecular Mechanisms ◽  
Drug Loading ◽  
Delivery Systems ◽  
Titanium Implants ◽  
Local Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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