scholarly journals Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice

Nanomedicine ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. 1423-1434 ◽  
Author(s):  
Ritesh K Shukla ◽  
Ashutosh Kumar ◽  
Naga Veera Srikanth Vallabani ◽  
Alok K Pandey ◽  
Alok Dhawan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Hepatic Injury ◽  
Titanium Dioxide Nanoparticle

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

2012 ◽  
Vol 26 (2) ◽  
pp. 351-361 ◽  
Author(s):  
Quaiser Saquib ◽  
Abdulaziz A. Al-Khedhairy ◽  
Maqsood A. Siddiqui ◽  
Faisal M. Abou-Tarboush ◽  
Ameer Azam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Human Amnion

scholarly journals Comparison of Oxidative Stresses Mediated by Different Crystalline Forms and Surface Modification of Titanium Dioxide Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Karim Samy El-Said ◽  
Ehab Mostafa Ali ◽  
Koki Kanehira ◽  
Akiyoshi Taniguchi
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Surface Modification ◽  
Titanium Dioxide Nanoparticles ◽  
Crystalline Form ◽  
Cellular Mechanisms ◽  
Oxidative Stresses ◽  
Wide Range ◽  
Crystalline Forms

Titanium dioxide nanoparticles (TiO2NPs) are manufactured worldwide for use in a wide range of applications. There are two common crystalline forms of TiO2anatase and rutile with different physical and chemical characteristics. We previously demonstrated that an increased DNA damage response is mediated by anatase crystalline form compared to rutile. In the present study, we conjugated TiO2NPs with polyethylene glycol (PEG) in order to reduce the genotoxicity and we evaluated some oxidative stress parameters to obtain information on the cellular mechanisms of DNA damage that operate in response to TiO2NPs different crystalline forms exposure in hepatocarcinoma cell lines (HepG2). Our results indicated a significant increase in oxidative stress mediated by the anatase form of TiO2NPs compared to rutile form. On the other hand, PEG modified TiO2NPs showed a significant decrease in oxidative stress as compared to TiO2NPs. These data suggested that the genotoxic potential of TiO2NPs varies with crystalline form and surface modification.

Mechanisms of titanium dioxide nanoparticle‐induced oxidative stress and modulation of plasma glucose in mice

2019 ◽  
Vol 34 (11) ◽  
pp. 1221-1235 ◽  
Author(s):  
Hailong Hu ◽  
Xingpei Fan ◽  
Yao Yin ◽  
Qian Guo ◽  
Daqian Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Plasma Glucose ◽  
Titanium Dioxide Nanoparticle
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