scholarly journals Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy

Nanomedicine ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Kvar CL Black ◽  
Ji Yi ◽  
José G Rivera ◽  
Daria C Zelasko-Leon ◽  
Phillip B Messersmith
Keyword(s):  
Cancer Cell ◽  
Surface Functionalization ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Targeted Imaging

scholarly journals Luminescent CaTiO3:Yb,Er nanofibers co-conjugated with Rose Bengal and gold nanorods for potential synergistic photodynamic/photothermal therapy

2017 ◽  
Vol 5 (26) ◽  
pp. 5128-5136 ◽  
Author(s):  
Yike Fu ◽  
Heng Liu ◽  
Zhaohui Ren ◽  
Xiang Li ◽  
Jie Huang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Gold Nanorods ◽  
Rose Bengal ◽  
Photothermal Therapy ◽  
Cell Killing ◽  
Killing Effect ◽  
Photothermal Phenomenon ◽  
Cell Killing Effect

CaTiO3:Yb,Er nanofibers, co-conjugated with Rose Bengal and gold nanorods, enable a synergistic photodynamic/photothermal phenomenon for superior cancer cell killing effect.

Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer

2020 ◽  
Vol 8 (32) ◽  
pp. 7253-7263
Author(s):  
Qiang Sun ◽  
Jinggen Wu ◽  
Lulu Jin ◽  
Liangjie Hong ◽  
Fang Wang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Squamous Cancer

Cancer cell membrane-coated gold nanorods are prepared for combinational photothermal therapy and radiation therapy of oral squamous cancer.

scholarly journals Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins

2017 ◽  
Vol 114 (28) ◽  
pp. E5655-E5663 ◽  
Author(s):  
Moustafa R. K. Ali ◽  
Yue Wu ◽  
Yan Tang ◽  
Haopeng Xiao ◽  
Kuangcai Chen ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Molecular Mechanisms ◽  
Cancer Metastasis ◽  
Dominant Role ◽  
Cytoskeletal Proteins ◽  
Microtubule Assembly ◽  
Cancer Cell Migration

Metastasis is responsible for most cancer-related deaths, but the current clinical treatments are not effective. Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell migration and prevent metastasis. Rationally designed AuNPs could greatly benefit their antimigration property, but the molecular mechanisms need to be explored. Cytoskeletons are cell structural proteins that closely relate to migration, and surface receptor integrins play critical roles in controlling the organization of cytoskeletons. Herein, we developed a strategy to inhibit cancer cell migration by targeting integrins, using Arg–Gly–Asp (RGD) peptide-functionalized gold nanorods. To enhance the effect, AuNRs were further activated with 808-nm near-infrared (NIR) light to generate heat for photothermal therapy (PPTT), where the temperature was adjusted not to affect the cell viability/proliferation. Our results demonstrate changes in cell morphology, observed as cytoskeleton protrusions—i.e., lamellipodia and filopodia—were reduced after treatment. The Western blot analysis indicates the downstream effectors of integrin were attracted toward the antimigration direction. Proteomics results indicated broad perturbations in four signaling pathways, Rho GTPases, actin, microtubule, and kinases-related pathways, which are the downstream regulators of integrins. Due to the dominant role of integrins in controlling cytoskeleton, focal adhesion, actomyosin contraction, and actin and microtubule assembly have been disrupted by targeting integrins. PPTT further enhanced the remodeling of cytoskeletal proteins and decreased migration. In summary, the ability of targeting AuNRs to cancer cell integrins and the introduction of PPTT stimulated broad regulation on the cytoskeleton, which provides the evidence for a potential medical application for controlling cancer metastasis.

scholarly journals Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

2021 ◽  
Vol 12 ◽  
Author(s):  
Shengnan Liao ◽  
Wang Yue ◽  
Shuning Cai ◽  
Quan Tang ◽  
Weitong Lu ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Recent Progress ◽  
Controlled Drug Release ◽  
Synthetic Methods ◽  
Cell Uptake ◽  
Photothermal Effect ◽  
Synthesis Methods ◽  
Novel Technologies

Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed.

Plasmon-induced hyperthermia: hybrid upconversion NaYF4:Yb/Er and gold nanomaterials for oral cancer photothermal therapy

2015 ◽  
Vol 3 (42) ◽  
pp. 8293-8302 ◽  
Author(s):  
Chieh-Wei Chen ◽  
Po-Han Lee ◽  
Yung-Chieh Chan ◽  
Michael Hsiao ◽  
Chung-Hsuan Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Upconversion Nanoparticles ◽  
Induced Hyperthermia ◽  
Oral Cancer Cell ◽  
Gold Nanomaterials

Bi-functional nanocomposites consisting of upconversion nanoparticles and gold nanoparticles or gold nanorods are fabricated for oral cancer cell photothermal therapy.

Human Induced Pluripotent Stem Cells for Tumor Targeted Delivery of Gold Nanorods and Enhanced Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 2375-2385 ◽  
Author(s):  
Yanlei Liu ◽  
Meng Yang ◽  
Jingpu Zhang ◽  
Xiao Zhi ◽  
Chao Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Gold Nanorods ◽  
Pluripotent Stem Cells ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Induced Pluripotent

Aptamer and RVG functionalized gold nanorods for targeted photothermal therapy of neurotropic virus infection in the mouse brain

2021 ◽  
Vol 411 ◽  
pp. 128557
Author(s):  
Meishen Ren ◽  
Jiaojiao Zhou ◽  
Zhiyong Song ◽  
Hong Mei ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Neurotropic Virus
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