Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats

Nanomedicine ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. 89-104 ◽  
Author(s):  
Rinku D Umrani ◽  
Kishore M Paknikar
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oxide Nanoparticles

scholarly journals Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats

2020 ◽  
Vol 14 (8) ◽  
pp. 680-687
Author(s):  
Norhan Elassy ◽  
Shady El-Dafrawy ◽  
Amira O. Abd El-Azim ◽  
Om Ali Y. El-Khawaga ◽  
Amr Negm
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Diabetic Rats ◽  
Oxide Nanoparticles ◽  
Inflammation Response ◽  
Glut 4

scholarly journals THERAPEUTIC EFFICACY OF ZINC OXIDE NANOPARTICLES IN DIABETIC RATS

2019 ◽  
Vol 56 (22-Suppl) ◽  
Author(s):  
Mohammed Kamal ◽  
Mohamed Khairy ◽  
Nada ELSadek ◽  
Mohamed Hussein
Keyword(s):  
Zinc Oxide ◽  
Therapeutic Efficacy ◽  
Zinc Oxide Nanoparticles ◽  
Diabetic Rats ◽  
Oxide Nanoparticles

scholarly journals Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

2021 ◽  
Vol Volume 16 ◽  
pp. 8221-8233
Author(s):  
Mina Michael Melk ◽  
Seham S El-Hawary ◽  
Farouk Rasmy Melek ◽  
Dalia Osama Saleh ◽  
Omar M Ali ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Herpes Simplex Virus Type ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Plumbago Indica ◽  
Simplex Virus

scholarly journals Ameliorative Effect of Zinc Oxide Nanoparticles on Antioxidants and Sperm Characteristics in Streptozotocin-Induced Diabetic Rat Testes

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed Afifi ◽  
Omar A. Almaghrabi ◽  
Naif Mohammed Kadasa
Keyword(s):  
Zinc Oxide ◽  
Mrna Expression ◽  
Zinc Oxide Nanoparticles ◽  
Sperm Count ◽  
Testicular Tissue ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Oxide Nanoparticles ◽  
Sperm Characteristics ◽  
The Impact

The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on the oxidative status and sperm characteristics in diabetic rat testicular tissue. Forty male albino rats were used in this study; 10 of them served as a control and 30 rats were injected with a single dose (100 mg/kg) of streptozotocin intraperitoneally. They were subdivided into diabetic, diabetic + ZnONPs (10 mg/kg B.W.), and diabetic and cotreated with ZnONPs + insulin groups. The sperm count and motility were assessed. The activity and mRNA expression of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRD), and Glutathion-S-Transferase (GST) were determined in the testicular tissue. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated in the testicular tissue. Sperm count and motility increased in ZnONPs treated diabetic rats. A significant increase in the activity and mRNA expression of SOD, CAT, GPx, GRD, and GST was shown in ZnONPs treated diabetic rats. MDA significantly decreased, while GSH increased in testicular tissue of ZnONPs treated diabetic rats. It was concluded that ZnONPs either alone or in combination with insulin have the ability to increase the sperm count and motility and protect the testicular tissue against the oxidative stress induced by diabetes in rats.

scholarly journals In vivo zinc oxide nanoparticles induces acute hyperglycemic response a dose-dependent and route of administration in healthy and diabetic rats  

2019 ◽  
Author(s):  
Jesús José Ibarra-Leal ◽  
Luis Yocupicio ◽  
Alejandro Apolinar-Iribe ◽  
Irene Díaz-Reval ◽  
Hortensia Parra-Delgado ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Experimental Diabetes ◽  
Intraperitoneal Administration ◽  
Diabetic Rats ◽  
Oxide Nanoparticles ◽  
Acute Effects ◽  
Fasting Glycemia ◽  
Dose Dependent

In recent years, different studies carried out in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) can be good antidiabetic agents, this evidence was obtained from long-term treatments using repeated doses of zinc oxide nanoparticles. The goal of this work was to evaluate the acute effects during six hours post-administration of ZnONPs on glycemia in healthy and diabetic rats and to compare the effects of oral and intraperitoneal administration. For this study male Wistar rats were used and experimental diabetes was induced by streptozotocin-nicotinamide intraperitoneal administration. At short-term ZnONPs administration induced hyperglycemic response in healthy and diabetic rats, the effect was dose-dependent and administration route. The diabetic rats were more sensitive to ZnONPs effect. In conclusion, this study provides novel information about the acute effects of zinc oxide nanoparticles on the fasting glycemia in experimental diabetes in vivo model and healthy rats, these data are important for its future clinical applications.

scholarly journals Evaluation of Zinc-oxide Nanoparticles effect on treatment of diabetes in streptozotocin-induced diabetic rats

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0 ◽  
Author(s):  
Mie Afify ◽  
Nervana Samy ◽  
Naglaa Hafez ◽  
Ahmed Alazzouni ◽  
El sayed Mahdy ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Diabetic Rats ◽  
Oxide Nanoparticles ◽  
Treatment Of Diabetes
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