Injectable photocrosslinkable nanocomposite based on poly(glycerol sebacate) fumarate and hydroxyapatite: development, biocompatibility and bone regeneration in a rat calvarial bone defect model

Nanomedicine ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. 1777-1795 ◽  
Author(s):  
Santosh Bodakhe ◽  
Shalini Verma ◽  
Kalpna Garkhal ◽  
Sanjaya K Samal ◽  
Shyam S Sharma ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

scholarly journals Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model

Materials ◽  
2016 ◽  
Vol 9 (2) ◽  
pp. 97 ◽  
Author(s):  
Jiyeon Roh ◽  
Ji-Youn Kim ◽  
Young-Muk Choi ◽  
Seong-Min Ha ◽  
Kyoung-Nam Kim ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

scholarly journals Erratum to: Osteoconduction capacity of human deciduous and permanent teeth ash in a rat calvarial bone defect model

2015 ◽  
Vol 16 (4) ◽  
pp. 651-651
Author(s):  
Boram Min ◽  
Je Seon Song ◽  
Seong-Oh Kim ◽  
Kwang-Mahn Kim ◽  
Won Se Park ◽  
...  
Keyword(s):  
Bone Defect ◽  
Permanent Teeth ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect

Peptides ◽  
2013 ◽  
Vol 46 ◽  
pp. 136-142 ◽  
Author(s):  
Mizuho Kittaka ◽  
Hideki Shiba ◽  
Mikihito Kajiya ◽  
Takako Fujita ◽  
Tomoyuki Iwata ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

Osteoconduction capacity of human deciduous and permanent teeth ash in a rat calvarial bone defect model

2014 ◽  
Vol 16 (3) ◽  
pp. 361-369 ◽  
Author(s):  
Boram Min ◽  
Je Seon Song ◽  
Seong-Oh Kim ◽  
Kwang-Mahn Kim ◽  
Won Se Park ◽  
...  
Keyword(s):  
Bone Defect ◽  
Permanent Teeth ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

scholarly journals In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 2023
Author(s):  
Fabien Kawecki ◽  
Todd Galbraith ◽  
William P. Clafshenkel ◽  
Michel Fortin ◽  
François A. Auger ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Repair ◽  
Human Bone ◽  
Male Rats ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect ◽  
Self Assembled

In vitro prevascularization has the potential to address the challenge of maintaining cell viability at the core of engineered constructs, such as bone substitutes, and to improve the survival of tissue grafts by allowing quicker anastomosis to the host microvasculature. The self-assembly approach of tissue engineering allows the production of biomimetic bone-like tissue constructs including extracellular matrix and living human adipose-derived stromal/stem cells (hASCs) induced towards osteogenic differentiation. We hypothesized that the addition of endothelial cells could improve osteogenesis and biomineralization during the production of self-assembled human bone-like tissues using hASCs. Additionally, we postulated that these prevascularized constructs would consequently improve graft survival and bone repair of rat calvarial bone defects. This study shows that a dense capillary network spontaneously formed in vitro during tissue biofabrication after two weeks of maturation. Despite reductions in osteocalcin levels and hydroxyapatite formation in vitro in prevascularized bone-like tissues (35 days of culture), in vivo imaging of prevascularized constructs showed an improvement in cell survival without impeding bone healing after 12 weeks of implantation in a calvarial bone defect model (immunocompromised male rats), compared to their stromal counterparts. Globally, these findings establish our ability to engineer prevascularized bone-like tissues with improved functional properties.

Carbon nanohorns accelerate bone regeneration in rat calvarial bone defect

2011 ◽  
Vol 22 (6) ◽  
pp. 065102 ◽  
Author(s):  
Takao Kasai ◽  
Sachiko Matsumura ◽  
Tadashi Iizuka ◽  
Kiyotaka Shiba ◽  
Takeshi Kanamori ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Calvarial Bone ◽  
Carbon Nanohorns ◽  
Calvarial Bone Defect
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