scholarly journals Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacyin vivo

Nanomedicine ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. 475-487 ◽  
Author(s):  
Diane E Marotta ◽  
Weiguo Cao ◽  
E Paul Wileyto ◽  
Hui Li ◽  
Ian Corbin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles

2005 ◽  
Vol 10 (4) ◽  
pp. 041203 ◽  
Author(s):  
Hui Li ◽  
Diane E. Marotta ◽  
Soungkyoo Kim ◽  
Theresa M. Busch ◽  
E. Paul Wileyto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Optical Imaging ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Payload

Selective aggregation of zinc phthalocyanines in the skin

2000 ◽  
Vol 04 (03) ◽  
pp. 278-284 ◽  
Author(s):  
KENJI TABATA ◽  
KAORU FUKUSHIMA ◽  
KAZUO ODA ◽  
ICHIRO OKURA
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Bovine Serum Albumin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Other ◽  
Low Density ◽  
Monomeric Form ◽  
Zinc Phthalocyanines ◽  
Selective Aggregation

In photodynamic therapy it is important to avoid undesirable side effects caused by photodynamic reactions with accumulated photosensitizers, especially in the skin. Although phthalocyanine monomers can serve as photosensitizers, aggregated phthalocyanines are inactive. In this study the aggregations of five zinc phthalocyanines (MSPc, TSPc, TX-101A, TX-105A and TX-106A) in the skin and in the tumor are compared. Every phthalocyanine was more dissociated in the tumor than in the skin. In particular, TX-101A and TX-106A remained in monomeric form in the tumor but were aggregated in the skin. The aggregation effects of phthalocyanines in organic solvents and biological materials were also investigated. These phthalocyanines were aggregated in water and ethanol and also by the addition of bovine serum albumin and ghosts of red cells. On the other hand, they were dissociated in propanol and also by the addition of low-density lipoprotein. It was found that the dissociation of these phthalocyanines depended strongly on the polarity of the solvents and on the biological microenvironment.

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

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