Nanoparticles as computed tomography contrast agents: current status and future perspectives

Nanomedicine ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. 257-269 ◽  
Author(s):  
Malka Shilo ◽  
Tobi Reuveni ◽  
Menachem Motiei ◽  
Rachela Popovtzer
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Current Status ◽  
Future Perspectives

MRI Contrast Agents: Current Status and Future Perspectives

2007 ◽  
Vol 7 (3) ◽  
pp. 291-305 ◽  
Author(s):  
Gustav Strijkers ◽  
Willem M. Mulder ◽  
Geralda F. van Tilborg ◽  
Klaas Nicolay
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Current Status ◽  
Future Perspectives ◽  
Mri Contrast

Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives

2010 ◽  
Vol 399 (1) ◽  
pp. 3-27 ◽  
Author(s):  
Megan A. Hahn ◽  
Amit K. Singh ◽  
Parvesh Sharma ◽  
Scott C. Brown ◽  
Brij M. Moudgil
Keyword(s):  
Contrast Agents ◽  
Current Status ◽  
Future Perspectives

Nonionic Low-Osmolar Monomeric Iodinated Contrast Material: Some Aspects of use for Computed Tomography in Children

2017 ◽  
pp. 118-129
Author(s):  
I. A. Kondrashov ◽  
V. Mandal
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Adverse Reactions ◽  
Contrast Material ◽  
Iodine Content ◽  
Diagnostic Procedures ◽  
Diagnostic Efficacy ◽  
Minimum Risk ◽  
Electrical Neutrality ◽  
Iodinated Contrast

Iodine containing contrast media are used much frequently now-a-days for computed tomography examinations in children. The group of non-ionic monomers occupies a special place among modern contrast agents. Low osmolarity and viscosity, electrical neutrality and the highest iodine content of these contrast materials provide the best diagnostic efficacy with minimum risk of adverse reactions. However, characteristic anatomic and physiological aspects of a growing child’s body require additional attention and care during diagnostic procedures with use of such contrast agents. This article presents concise literature review of recent years highlighting practical aspects of nonionic lowosmolar iodinated contrast material use for computed tomography assisted diagnostic examinations in child population.

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

2018 ◽  
Vol 23 (37) ◽  
pp. 5760-5765 ◽  
Author(s):  
Antonio Gambardella ◽  
Angelo Labate ◽  
Laura Mumoli ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Current Status ◽  
Future Perspectives ◽  
Antiepileptic Drug Therapy

Radio-localization of Non-Palpable Breast Lesions Under Ultrasonographic Guidance: Current Status and Future Perspectives

2017 ◽  
Vol 10 (3) ◽  
Author(s):  
Giulia Anna Follacchio ◽  
Francesco Monteleone ◽  
Maria Letizia Meggiorini ◽  
Maria Paola Nusiner ◽  
Carlo De Felice ◽  
...  
Keyword(s):  
Current Status ◽  
Breast Lesions ◽  
Future Perspectives ◽  
Radio Localization ◽  
Palpable Breast ◽  
Ultrasonographic Guidance
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