Functional gold nanoparticle-based antibacterial agents for nosocomial and antibiotic-resistant bacteria

Nanomedicine ◽  
2016 ◽  
Vol 11 (19) ◽  
pp. 2497-2510 ◽  
Author(s):  
Yen-Ling Kuo ◽  
Sin-Ge Wang ◽  
Ching-Yi Wu ◽  
Kai-Chieh Lee ◽  
Chan-Jung Jao ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Antibacterial Agents ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

Recent Advances in Peptide Nucleic Acids as Antibacterial Agents

2020 ◽  
Vol 27 ◽  
Author(s):  
Wei Chen ◽  
Bo Dong ◽  
Wenen Liu ◽  
Zhengchun Liu
Keyword(s):  
Messenger Rna ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Resistant Bacteria ◽  
Attractive Alternative ◽  
Dependent Manner ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Recent Advances ◽  
Hybrid Complex

: The emergence of antibiotic-resistant bacteria and the slow progress in searching for new antimicrobial agents make it hard to treat bacterial infections and cause problems for the healthcare system worldwide, including high costs, prolonged hospitalizations, and increased mortality. Therefore, the discovery of effective antibacterial agents is of great importance. One attractive alternative is antisense peptide nucleic acid (PNA), which inhibits or eliminates gene expression by binding to the complementary messenger RNA (mRNA) sequence of essential genes or the accessible and functionally important regions of the ribosomal RNA (rRNA). Following 30 years of development, PNAs have played an extremely important role in the treatment of Gram-positive, Gram-negative, and acidfast bacteria due to their desirable stability of hybrid complex with target RNA, the strong affinity for target mRNA/rRNA, and the stability against nucleases. PNA-based antisense antibiotics can strongly inhibit the growth of pathogenic and antibiotic-resistant bacteria in a sequence-specific and dose-dependent manner at micromolar concentrations. However, several fundamental challenges, such as intracellular delivery, solubility, physiological stability, and clearance, still need to be addressed before PNAs become broadly applicable in clinical settings. In this review, we summarize the recent advances in PNAs as antibacterial agents and the challenges that need to be overcome in the future.

scholarly journals A WS2-gold nanoparticle heterostructure-based novel SERS platform for the rapid identification of antibiotic-resistant pathogens

2020 ◽  
Vol 2 (5) ◽  
pp. 2025-2033 ◽  
Author(s):  
Avijit Pramanik ◽  
Dalephine Davis ◽  
Shamily Patibandla ◽  
Salma Begum ◽  
Priyadarshini Ray ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Rapid Identification ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

The emergence of antibiotic-resistant bacteria is the biggest threat to our society.

The Frequency of Antibiotic-Resistant Bacteria in Homes Differing in Their Use of Surface Antibacterial Agents

2012 ◽  
Vol 65 (4) ◽  
pp. 407-415 ◽  
Author(s):  
Bonnie M. Marshall ◽  
Eduardo Robleto ◽  
Theresa Dumont ◽  
Stuart B. Levy
Keyword(s):  
Antibacterial Agents ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

scholarly journals The Synthesis and Characterizes of Nano-Metallic Particles Against Antibiotic Resistant Bacteria, Isolated from Rasoul-e-Akram Hospital’s Patients, Tehran, Iran

2016 ◽  
Vol 6 (1) ◽  
pp. 80 ◽  
Author(s):  
Alireza Jafari ◽  
Ali Majidpour ◽  
Roya Safarkar ◽  
Seyyedeh Masumeh Mirnurollahi ◽  
Shahrdad Arastoo
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Antibacterial Agents ◽  
High Sensitivity ◽  
Resistant Bacteria ◽  
Klebsiella Pneumonia ◽  
Antibiotic Resistant Bacteria ◽  
Zno Nps ◽  
Gram Positive ◽  
Antibiotic Resistant

<p class="1Body">The emergence of antimicrobial resistance of microorganisms to antibiotics, Also, an increase in nosocomial infections, particularly by <em>Methicillin Resistant Staphylococcus aureus </em>(<em>MRSA</em>), <em>Pseudomonas aeruginosa</em>, the need to discover new antibacterial agents with a mechanism of action different from killing bacteria were more than ever before. The Ag nanoparticles (NPs), ZnO (NPs) and Ag/ZnO (NPs) were synthesized through the thermal decomposition of the precursor of oxalate. Gram-negative antibiotic resistant bacteria and Gram-positive antibiotic resistant bacteria were prepared from the Central laboratory of Rasoul-e-Akram hospital. All of isolates were confirmed by biochemical tests. For determine of antibiotic resistance patterns of isolated, disk diffusion method in accordance with the standard CLSI were used, again. Antibacterial effects of (NPs) against antibiotic resistance bacteria were conducted by MIC and MBC tests. The particles size was less of 50 nm, approximately. Curiously, the silver (NPs) was not exposed the antibacterial properties against all of isolated bacteria. Also, <em>klebsiella pneumonia</em> and <em>MRSA</em> had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. Interestingly, The MBC for ZnO (NPs) against <em>Pseudomonas aeruginosa </em>&gt;= 8192 was observed. The Ag (NPs) had not the ability to inhibit the nosocomial infection. <em>klebsiella pneumonia</em> and <em>MRSA</em> had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic-resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. The Ag/ZnO (NPs) was ability to kill antibiotics resistant bacteria. The antibacterial agents can open a new leaf in our life in the treatment of nosocomial infections.</p>

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