The value of cerebrospinal fluid biomarkers for the differential diagnosis of dementia

2012 ◽  
Vol 2 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Nathalie Le Bastard ◽  
Sebastiaan Engelborghs
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Cerebrospinal Fluid Biomarkers ◽  
Diagnosis Of Dementia ◽  
Differential Diagnosis Of Dementia

Cerebrospinal Fluid: When Is It Worthwhile to Do a Lumbar Puncture?

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S16) ◽  
pp. 25-27
Author(s):  
Elaine R. Peskind
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Frontotemporal Dementia ◽  
Lumbar Puncture ◽  
Tau Proteins ◽  
Cns Infection ◽  
Rapid Decline ◽  
Practice Parameters ◽  
Diagnosis Of Dementia ◽  
Differential Diagnosis Of Dementia

Clinicians should have an understanding of a lumbar puncture is indicated in the differential diagnosis of dementia and delirium. In most cases, this procedure is not commonly performed in outpatient practice for the differential diagnosis of dementia. However, in patients who have acute or subacute onset or a very rapid decline—such as in suspected Creutzfeldt-Jakob disease (CJD)—cerebrospinal fluid (CSF) 14-3-3, and tau proteins can be diagnostic for at least sporadic CJD. Practice parameters from the American Academy of Neurology (AAN) suggest performing a spinal tap on patients ≤55 years of age. However, that recommendation may not always be beneficial, particularly in a patient who has a prominent family history of either Alzheimer’s disease (AD) or frontotemporal dementia. Per the AAN practice parameter, lumbar puncture for CSF analysis is indicated in the diagnosis of central nervous system (CNS) infection, carcinomatous meningitis, or CNS vasculitis.Beyond the clinically indicated lumbar puncture, there is utility of CSF biomarkers, including CSF Aβ42, total tau, and phospho-tau, which are the best studied. These biomarkers may be useful for cases involving atypical presentations of dementia, eg, when it is difficult to determine if the patient has AD versus frontotemporal dementia. They may be most useful for cases in which there is an atypical presentation of the fluorodeoxyglucose PET image or PET image features of both AD and frontotemporal dementia.

scholarly journals Diagnosis of Dementia and Cognitive Impairment

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 180
Author(s):  
Larner
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Cognitive Disorders ◽  
Clinical Encounter ◽  
Cognitive Screening ◽  
Special Issue ◽  
Neurological Signs ◽  
Cerebrospinal Fluid Biomarkers ◽  
Diagnosis Of Dementia

In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.

Differential Diagnosis of Dementia with High Levels of Cerebrospinal Fluid Tau Protein

2016 ◽  
Vol 51 (3) ◽  
pp. 905-913 ◽  
Author(s):  
Lou Grangeon ◽  
Claire Paquet ◽  
Stephanie Bombois ◽  
Muriel Quillard-Muraine ◽  
Olivier Martinaud ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Tau Protein ◽  
Diagnosis Of Dementia ◽  
Differential Diagnosis Of Dementia
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