Comparison of dengue virus and HCV: from impact on global health to their RNA-dependent RNA polymerases

2014 ◽  
Vol 9 (1) ◽  
pp. 53-67 ◽  
Author(s):  
Supanee Potisopon ◽  
Stéphane Priet ◽  
Barbara Selisko ◽  
Bruno Canard
Keyword(s):  
Global Health ◽  
Dengue Virus ◽  
Rna Polymerases

scholarly journals Afucosylated maternal anti-dengue IgGs are a biomarker for susceptibility to dengue disease in their infants

2019 ◽  
Author(s):  
Natalie K. Thulin ◽  
R. Camille Brewer ◽  
Robert Sherwood ◽  
Stylianos Bournazos ◽  
Karlie G. Edwards ◽  
...  
Keyword(s):  
Infant Mortality ◽  
Global Health ◽  
Dengue Virus ◽  
Virus Replication ◽  
Severe Disease ◽  
Antibody Dependent Enhancement ◽  
Dengue Disease ◽  
Health Burden ◽  
Post Entry ◽  
Activating Receptor

SummaryInfant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. While most primary infant dengue infections are asymptomatic, maternally derived anti-dengue IgGs present during infection can trigger progression to severe disease through antibody-dependent enhancement mechanisms. Importantly, specific characteristics of maternal IgGs that herald progression to severe infant dengue are unknown. Here, we define ≥10% afucosylation of maternal anti-dengue IgGs as a biomarker for susceptibility of infants to symptomatic dengue infections. Mechanistic experiments show that anti-dengue afucosylation, a modification that enhances Fc affinity for the activating receptor FcγRIIIa, promotes infection of FcγRIIIa+ monocytes. FcγRIIIa signaling, in turn, enhances a post-entry step of dengue virus replication. These studies identify a biomarker that can be applied to reduce mortality associated with dengue viruses and define a mechanism by which afucosylated antibodies and FcγRIIIa enhance dengue infections.

scholarly journals Ivermectin: An Anti-Parasitic Drug that has Potential for Repurposing for COVID-19

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 31-32
Author(s):  
Maryam Rashid ◽  
Mariyam Iftikhar Piracha
Keyword(s):  
Human Immunodeficiency Virus ◽  
Global Health ◽  
Antiviral Activity ◽  
Dengue Virus ◽  
Broad Spectrum ◽  
Macrocyclic Lactone ◽  
Antiviral Drug ◽  
Viral Rna ◽  
Deep Impact ◽  
Immunodeficiency Virus

<p>After global health catastrophe due to Coronavirus disease-2019 (COVID-19), a deep impact on the way we perceive our world and our everyday lives has been imprinted. Till now, no specific antiviral drug has been proven effective for curing patients. Ivermectin, the broad-spectrum macrocyclic lactone has proven to exert antiviral activity against human immunodeficiency virus (HIV), dengue virus and now capability to reduce viral RNA up to 5,000-fold after 48 h of infection with SARS-CoV-2.</p>

Plant Medicines Key to Global Health

2011 ◽  
pp. 061611145657
Author(s):  
Geoffrey Cordell
Keyword(s):  
Global Health

Combining a global health budget with a market-driven delivery system: Can it be done?

1993 ◽  
Vol 48 (3) ◽  
pp. 270-276 ◽  
Author(s):  
Jeff Bingaman ◽  
Robert G. Frank ◽  
Carrie L. Billy
Keyword(s):  
Global Health ◽  
Delivery System ◽  
Health Budget ◽  
Market Driven
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