African ancestry and innate immunity contribute to the incidence of multicentric Castleman’s disease in HIV-1/Kaposi’s sarcoma herpesvirus-coinfected individuals

2012 ◽  
Vol 7 (7) ◽  
pp. 729-734 ◽  
Author(s):  
Samantha J Westrop ◽  
Dimitrios Lagos ◽  
Chris Boshoff ◽  
Mark Bower ◽  
Nesrina Imami
Keyword(s):  
Innate Immunity ◽  
Kaposi's Sarcoma ◽  
African Ancestry ◽  
Castleman’S Disease ◽  
Kaposi’S Sarcoma ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Multicentric Castleman's Disease ◽  
Hiv 1

scholarly journals Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]

Blood ◽  
1995 ◽  
Vol 86 (4) ◽  
pp. 1276-1280 ◽  
Author(s):  
J Soulier ◽  
L Grollet ◽  
E Oksenhendler ◽  
P Cacoub ◽  
D Cazals-Hatem ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Kaposi's Sarcoma ◽  
Close Association ◽  
Castleman’S Disease ◽  
Kaposi’S Sarcoma ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Negative Case ◽  
Multicentric Castleman's Disease ◽  
Hiv Negative

Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HIV)-associated MCD cases and also, but less frequently, in HIV-negative patients. Recently, sequences of a putative new Herpesvirus (KSHV) have been isolated and further detected in almost all the acquired immunodeficiency syndrome (AIDS) KS and in most of the non-AIDS KS samples. In this study, we searched for these Herpesvirus-like sequences in MCD samples of 31 patients. KSHV sequences were detected in 14 of 14 cases of HIV-associated MCD, including 5 cases without detectable KS. Moreover, KSHV was detected in 7 of 17 MCD cases in HIV-negative patients, including 1 case associated with a cutaneous KS. In 34 non-MCD reactive lymph nodes (follicular and/or interfollicular hyperplasia) in HIV-negative patients, KSHV was detected in only 1 case. In 1 HIV-negative case of MCD, KSHV was found in both the lymph node and peripheral blood samples. These data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients.

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