Interferon-induced gene expression in chronic hepatitis C

2010 ◽  
Vol 5 (1) ◽  
pp. 25-31
Author(s):  
Magdalena Sarasin-Filipowicz ◽  
Markus H Heim
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C

Liver Gene Expression Signature of Mild Fibrosis in Patients With Chronic Hepatitis C

2005 ◽  
Vol 129 (6) ◽  
pp. 2064-2075 ◽  
Author(s):  
Tarik Asselah ◽  
Ivan Bièche ◽  
Ingrid Laurendeau ◽  
Valérie Paradis ◽  
Dominique Vidaud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Liver Gene

scholarly journals Interferon type I gene expression in chronic hepatitis C

2004 ◽  
Vol 84 (9) ◽  
pp. 1148-1159 ◽  
Author(s):  
Sabine Mihm ◽  
Michael Frese ◽  
Volker Meier ◽  
Perdita Wietzke-Braun ◽  
Jens-Gerd Scharf ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Type I ◽  
I Gene

Cell surface expression of LDL receptor in chronic hepatitis C: correlation with viral load

2007 ◽  
Vol 293 (1) ◽  
pp. E416-E420 ◽  
Author(s):  
Jean-Michel Petit ◽  
Anne Minello ◽  
Laurence Duvillard ◽  
Valérie Jooste ◽  
Serge Monier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Cell Surface ◽  
Chronic Hepatitis C ◽  
Mononuclear Cells ◽  
Ldl Receptor ◽  
Surface Expression ◽  
Cell Surface Expression

The LDL receptor (LDL-R) has been proposed as the viral receptor for Hepatitis C virus (HCV). This hypothesis has been based exclusively on in vitro studies. In human mononuclear cells, LDL-R gene expression has been demonstrated to be parallel and be coordinately regulated to gene expression in the human liver. The purpose of the current study was to determine the mononuclear cell surface expression of the LDL receptor in patients with HCV chronic infection according to viral load. Sixty-eight consecutive untreated chronic hepatitis C patients were studied to determine the mononuclear cell surface expression of the LDL-R. LDL-Rs were quantified at the surface of mononuclear cells in fresh blood samples taken after fasting using flow cytometry. LDL-R expression was significantly associated with LDL-cholesterol ( r = −0.25; P = 0.03) and HCV-viral load ( r = 0.37, P = 0.002). In multivariate analysis, the LDL-R expression was significantly associated with HCV viral load, whereas genotype, age, body mass index, and fibrosis were not. In conclusion, our data provided by a human study, suggest that the LDL-R may be one of the receptors implicated in HCV replication.

scholarly journals Hepatic TLR4, MBL and CRP gene expression levels are associated with chronic hepatitis C

2020 ◽  
Vol 80 ◽  
pp. 104200 ◽  
Author(s):  
Orlando de Souza Pires-Neto ◽  
Ednelza da Silva Graça Amoras ◽  
Maria Alice Freitas Queiroz ◽  
Sâmia Demachki ◽  
Simone Regina da Silva Conde ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Expression Levels ◽  
Gene Expression Levels
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