High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma

2016 ◽  
Vol 12 (3) ◽  
pp. 323-331 ◽  
Author(s):  
Nada Salem ◽  
Ibrahim Kamal ◽  
Jaudah Al-Maghrabi ◽  
Adel Abuzenadah ◽  
Abdul Ali Peer-Zada ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Colorectal Carcinoma ◽  
Survival Outcome ◽  
High Expression ◽  
Poor Survival ◽  
Poor Survival Outcome

scholarly journals High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 47943-47956 ◽  
Author(s):  
Li Yang ◽  
Xiao-Lu Lin ◽  
Wei Liang ◽  
Seng-Wang Fu ◽  
Wen-Feng Lin ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Progression ◽  
Survival Outcome ◽  
High Expression ◽  
Poor Survival ◽  
Poor Survival Outcome

scholarly journals Linc01194 acts as an oncogene in colorectal carcinoma and is associated with poor survival outcome

2019 ◽  
Vol Volume 11 ◽  
pp. 2349-2362 ◽  
Author(s):  
Xiaoxue Wang ◽  
Zhimin Liu ◽  
Hong Tong ◽  
Hui Peng ◽  
Zhenyu Xian ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumors Have a Poor Survival Outcome: A Multicenter Observational Study

2020 ◽  
Vol Volume 12 ◽  
pp. 10491-10504
Author(s):  
Weixian Hu ◽  
Chengbin Zheng ◽  
Renjie Li ◽  
Xingyu Feng ◽  
Guoliang Zheng ◽  
...  
Keyword(s):  
Observational Study ◽  
Survival Outcome ◽  
Poor Survival ◽  
Multicenter Observational Study ◽  
Stromal Tumors ◽  
Poor Survival Outcome

scholarly journals LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10171-10172
Author(s):  
Biao Zheng ◽  
Jianhua Qu ◽  
Kenoki Ohuchida ◽  
Haimin Feng ◽  
Stephen Jun Fei Chong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
High Liver

scholarly journals Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

2020 ◽  
Author(s):  
Toshiaki Iwase ◽  
Kenichi Harano ◽  
Hiroko Masuda ◽  
Kumiko Kida ◽  
Kenneth R. Hess ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Inflammatory Breast Cancer ◽  
Hormone Receptor ◽  
Survival Outcome ◽  
Stage Iii ◽  
Prognostic Role ◽  
Poor Survival ◽  
Poor Survival Outcome

Abstract Purpose: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses for 137 patients with HR+/HER2– IBC and 252 patients with corresponding non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and NAC outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Increased HR positivity was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

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