Cytokeratin 19-positive circulating tumor cells in early breast cancer prognosis

2010 ◽  
Vol 6 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Emmanouil Saloustros ◽  
Dimitris Mavroudis
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Early Breast Cancer ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Cytokeratin 19

Cytokeratin-19 mRNA-Positive Circulating Tumor Cells After Adjuvant Chemotherapy in Patients With Early Breast Cancer

2009 ◽  
Vol 27 (13) ◽  
pp. 2177-2184 ◽  
Author(s):  
Nikolaos Xenidis ◽  
Michail Ignatiadis ◽  
Stella Apostolaki ◽  
Maria Perraki ◽  
Kostas Kalbakis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Adjuvant Chemotherapy ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Early Breast Cancer ◽  
Prognostic Significance ◽  
Cytokeratin 19 ◽  
Axillary Lymph ◽  
Disease Free

Purpose To evaluate the prognostic significance of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in peripheral blood of women with early-stage breast cancer after the completion of adjuvant chemotherapy. Patients and Methods Blood was obtained from 437 patients with early breast cancer before the start and after the completion of adjuvant chemotherapy, and the presence of CK-19 mRNA-positive CTCs was assessed by real-time reverse transcriptase polymerase chain reaction. Interaction with known prognostic factors and association of CTCs with clinical outcome were investigated. Results CK-19 mRNA-positive CTCs were detected before chemotherapy in 179 patients (41.0%). After adjuvant chemotherapy, a significant change in CK-19 status was observed, as status for 51% of patients with initially CK-19 mRNA-positive disease turned negative, and status for 22% of patients with initially CK-19 mRNA-negative disease became positive (McNemar test P = .004). The detection of CK-19 mRNA-positive CTCs postchemotherapy was associated with involvement of more than three axillary lymph nodes (P = .026). Clinical relapses and disease-related deaths were significantly increased in patients with detectable postchemotherapy CK-19 mRNA-positive CTCs (both P < .001, respectively). Disease-free and overall survival were significantly reduced in patients with detectable CK-19 mRNA-positive CTCs postchemotherapy (P < .001 and P = .001, respectively). In multivariate analysis, the detection of CK-19 mRNA-positive CTCs before and after adjuvant chemotherapy was an independent factor associated with reduced disease-free survival (P < .001) and overall survival (P = .003). Conclusion The detection of CK-19 mRNA-positive CTCs in the blood after adjuvant chemotherapy is an independent risk factor indicating the presence of chemotherapy-resistant residual disease.

scholarly journals 0060 Circulating tumor cells in early breast cancer - multimarker analysis

The Breast ◽  
2009 ◽  
Vol 18 ◽  
pp. S33
Author(s):  
A. de Albuquerque ◽  
N. Fersis ◽  
L. Sisic ◽  
S. Kaul
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Early Breast Cancer

scholarly journals Prognostic Value of Circulating Tumor Cells in Early Breast Cancer Patients Detected by RT-PCR of Mamaglobin

2012 ◽  
Vol 23 ◽  
pp. ix111-ix112
Author(s):  
A.M. Hilal ◽  
H.M. Elzawahrey ◽  
A.A. Abd Elwahab ◽  
M.N. Abdelhafez ◽  
M.M. Moneer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Early Breast Cancer ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Rt Pcr
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