Seizures in children treated for a primary brain tumor: risk factors, evaluation and management

2014 ◽  
Vol 9 (6) ◽  
pp. 627-637 ◽  
Author(s):  
Emily A Gertsch ◽  
Nicole J Ullrich
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Primary Brain Tumor ◽  
Tumor Risk

scholarly journals PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Omid Reza Tamtaji ◽  
Mohammad Behnam ◽  
Mohammad Ali Pourattar ◽  
Michael R. Hamblin ◽  
Maryam Mahjoubin-Tehran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Health Problem ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Epigenetic Mechanisms ◽  
Major Health Problem ◽  
Major Health ◽  
The World ◽  
Cellular Pathways

AbstractGlioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma.

scholarly journals Brain tumors risk factors - current state of knowledge review

2021 ◽  
Vol 11 (9) ◽  
pp. 101-107
Author(s):  
Zygmunt Siedlecki ◽  
Małgorzata Szafrańska ◽  
Emilia Główczewska-Siedlecka ◽  
Maciej Śniegocki
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Ionizing Radiation ◽  
Brain Tumors ◽  
Poor Prognosis ◽  
Primary Brain Tumor ◽  
Evidence Based ◽  
Raw Meat ◽  
The Public ◽  
Current State

Brain tumors cause widespread apprehension in society, associated with poor prognosis and death. Laymen most often associate them with glioblastoma multiforme which is in fact the most common malignant primary brain tumor (formerly it was considered the most common primary brain tumor, now it is thought that meningiomas are the most common). The interest of both the public and physicians is aroused by potential brain tumors risk factors. The only evidence based risk factor is ionizing radiation of head and neck. Other risk factors are also under consideration, however are not conclusive and different studies give different results. Given the widespread apprehension of brain tumors, knowledge of the risk factors seems obvious. In this manuscript, we have reviewed the current state of knowledge aboutf risk factors based on research. They confirm that apart from ionizing radiation, the existence of other risk factors is considered: cell phones, electromagnetic field, occupational exposure to raw meat, viruses. However, all these risk factors are not confirmed by reference results.

scholarly journals Risk factors for fatigue severity in primary brain tumor patients

Cancer ◽  
2010 ◽  
pp. NA-NA ◽  
Author(s):  
Terri S. Armstrong ◽  
Stanley G. Cron ◽  
Elizabeth Vera Bolanos ◽  
Mark R. Gilbert ◽  
Duck-Hee Kang
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Primary Brain Tumor ◽  
Tumor Patients ◽  
Fatigue Severity

Diet and serum markers in relation to primary brain tumor risk in China

1994 ◽  
Vol 22 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Wan‐De Guo ◽  
Martha S. Linet ◽  
Wong‐Ho Chow ◽  
Jun‐Yao Li ◽  
William J. Blot
Keyword(s):  
Brain Tumor ◽  
Serum Markers ◽  
Primary Brain Tumor ◽  
Tumor Risk

scholarly journals Incidence, risk factors and outcomes of seizures occurring after craniotomy for primary brain tumor resection

Neurosciences ◽  
2017 ◽  
Vol 22 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Hasan Al-Dorzi ◽  
Abdullah Alruwaita ◽  
Bothaina Marae ◽  
Bushra Alraddadi ◽  
Hani Tamim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Tumor Resection ◽  
Primary Brain Tumor ◽  
Incidence Risk ◽  
Brain Tumor Resection

Association of the MTHFR C677T polymorphism with primary brain tumor risk

Tumor Biology ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 3457-3464 ◽  
Author(s):  
Chen Xu ◽  
Lutao Yuan ◽  
Hengli Tian ◽  
Heli Cao ◽  
Shiwen Chen
Keyword(s):  
Brain Tumor ◽  
Mthfr C677t ◽  
Primary Brain Tumor ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Tumor Risk

scholarly journals Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1411
Author(s):  
Don Carlo Ramos Batara ◽  
Moon-Chang Choi ◽  
Hyeon-Uk Shin ◽  
Hyunggee Kim ◽  
Sung-Hak Kim
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Molecular Target ◽  
Therapeutic Strategies ◽  
Homeostatic Mechanism ◽  
Cellular Context ◽  
Cellular Components

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy’s pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.

scholarly journals Molecular Mechanisms of Drug Resistance in Glioblastoma

2021 ◽  
Vol 22 (12) ◽  
pp. 6385
Author(s):  
Maya A. Dymova ◽  
Elena V. Kuligina ◽  
Vladimir A. Richter
Keyword(s):  
Drug Resistance ◽  
Brain Tumor ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Therapeutic Resistance ◽  
Molecular Characteristics ◽  
Blood Brain ◽  
Conventional Radiation ◽  
The Brain ◽  
Made In

Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB).

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