scholarly journals Bacterial genome evolution within a clonal population: fromin vitroinvestigations toin vivoobservations

2013 ◽  
Vol 8 (5) ◽  
pp. 661-674 ◽  
Author(s):  
Marie Beaume ◽  
Nadezda Monina ◽  
Jacques Schrenzel ◽  
Patrice François
Keyword(s):  
Genome Evolution ◽  
Bacterial Genome ◽  
Clonal Population

scholarly journals An algebraic view of bacterial genome evolution

2013 ◽  
Vol 69 (6-7) ◽  
pp. 1693-1718 ◽  
Author(s):  
Andrew R. Francis
Keyword(s):  
Genome Evolution ◽  
Bacterial Genome

scholarly journals Replicon-Dependent Bacterial Genome Evolution: The Case of Sinorhizobium meliloti

2013 ◽  
Vol 5 (3) ◽  
pp. 542-558 ◽  
Author(s):  
Marco Galardini ◽  
Francesco Pini ◽  
Marco Bazzicalupo ◽  
Emanuele G. Biondi ◽  
Alessio Mengoni
Keyword(s):  
Genome Evolution ◽  
Sinorhizobium Meliloti ◽  
Bacterial Genome

scholarly journals Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing

2018 ◽  
Vol 115 (51) ◽  
pp. 12872-12877 ◽  
Author(s):  
Elizabeth J. Klemm ◽  
Vanessa K. Wong ◽  
Gordon Dougan
Keyword(s):  
Antibiotic Resistance ◽  
Whole Genome Sequencing ◽  
Genome Evolution ◽  
Genome Sequencing ◽  
Bacterial Genome ◽  
Multidrug Resistant ◽  
Whole Genome ◽  
Bacterial Populations ◽  
Global Challenge ◽  
The Past

Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years, compromising our ability to effectively treat infections. There has been a dramatic increase in antibiotic resistance-associated determinants in bacterial populations, driven by the mobility and infectious nature of such determinants. Bacterial genome flexibility and antibiotic-driven selection are at the root of the problem. Genome evolution and the emergence of highly successful multidrug-resistant clades in different pathogens have made this a global challenge. Here, we describe some of the factors driving the origin, evolution, and spread of the antibiotic resistance genotype.

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