Pulmonary disease due to nontuberculous mycobacteria: an epidemiologist’s view

2010 ◽  
Vol 5 (3) ◽  
pp. 343-345 ◽  
Author(s):  
Kevin L Winthrop
Keyword(s):  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria

scholarly journals Lower Recovery of Nontuberculous Mycobacteria from Outdoor Hawai’i Environmental Water Biofilms Compared to Indoor Samples

2021 ◽  
Vol 9 (2) ◽  
pp. 224
Author(s):  
Ravleen Virdi ◽  
Melissa E. Lowe ◽  
Grant J. Norton ◽  
Stephanie N. Dawrs ◽  
Nabeeh A. Hasan ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Environmental Samples ◽  
Nontuberculous Mycobacteria ◽  
Phylogenetic Analyses ◽  
Environmental Water ◽  
Rpob Gene ◽  
The United States ◽  
Indoor Environments ◽  
Respiratory Specimens ◽  
Rpob Sequence

Nontuberculous mycobacteria (NTM) are environmental organisms that can cause opportunistic pulmonary disease with species diversity showing significant regional variation. In the United States, Hawai’i shows the highest rate of NTM pulmonary disease. The need for improved understanding of NTM reservoirs led us to identify NTM from patient respiratory specimens and compare NTM diversity between outdoor and indoor locations in Hawai’i. A total of 545 water biofilm samples were collected from 357 unique locations across Kaua’i (n = 51), O’ahu (n = 202), Maui (n = 159), and Hawai’i Island (n = 133) and divided into outdoor (n = 179) or indoor (n = 366) categories. rpoB sequence analysis was used to determine NTM species and predictive modeling applied to develop NTM risk maps based on geographic characteristics between environments. M. chimaera was frequently identified from respiratory and environmental samples followed by M. chelonae and M. abscessus; yet significantly less NTM were consistently recovered from outdoor compared to indoor biofilms, as exemplified by showerhead biofilm samples. While the frequency of M. chimaera recovery was comparable between outdoor and indoor showerhead biofilms, phylogenetic analyses demonstrate similar rpoB gene sequences between all showerhead and respiratory M. chimaera isolates, supporting outdoor and indoor environments as possible sources for pulmonary M. chimaera infections.

scholarly journals Epidemiology of pulmonary disease due to nontuberculous mycobacteria in Southern China, 2013–2016

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Yaoju Tan ◽  
Biyi Su ◽  
Wei Shu ◽  
Xingshan Cai ◽  
Shaojia Kuang ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria ◽  
Southern China

scholarly journals HIV-negative pulmonary disease caused by nontuberculous mycobacteria in Southern Brazil: clinical and microbiological characterization

2018 ◽  
Vol 10 (3) ◽  
pp. 1903-1911 ◽  
Author(s):  
Fernanda Guioti Puga ◽  
Renata Helena Candido Pocente ◽  
Erica Chimara ◽  
Valdes Roberto Bollela
Keyword(s):  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria ◽  
Southern Brazil ◽  
Hiv Negative

Pulmonary disease caused by nontuberculous mycobacteria

1990 ◽  
Vol 5 (2) ◽  
pp. 64-76 ◽  
Author(s):  
John H. Woodring ◽  
H. Mac Vandiviere
Keyword(s):  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria

scholarly journals Nontuberculous mycobacteria isolated from specimens of pulmonary tuberculosis suspects, Northern Tunisia: 2002–2016

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Reem Gharbi ◽  
Besma Mhenni ◽  
Saloua Ben Fraj ◽  
Helmi Mardassi
Keyword(s):  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria ◽  
Taxonomic Status ◽  
Northern Tunisia ◽  
Main Driver ◽  
Tunisian Patients ◽  
Effective Role ◽  
Tract Infections ◽  
Low Prevalence ◽  
Hiv Negative

Abstract Background Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling. However, as yet, there are no such data relating to Tunisia. Methods Here we carried out a retrospective review of mycobacterial cultures originating from Northern Tunisia, which have been processed in the laboratory of mycobacteria of the Institut Pasteur de Tunis, during the time period 2002–2016. All pulmonary NTM (PNTM) isolates available for culture were characterized phenotypically and their taxonomic status was further established based on polymorphisms in rpoB, 16S rRNA, hsp65, and sodA DNA gene sequences. Results Of the 10,466 specimens collected from HIV-negative Tunisian patients with presumptive clinical pulmonary TB, 60 (0.6%) yielded PNTM isolates. An overall annual PNTM isolation prevalence of 0.2/100,000 was estimated. As far as could be ascertained, this isolation rate accounts amongst the lowest reported hitherto throughout the world. Among the 30 NTM isolates that were available for culture, 27 (90.0%) have been identified to the species level. The most commonly encountered species was Mycobacterium kansasii (23.3%) subtype 1. Strikingly, all M. kansasii cases were male patients originating from Bizerte, an industrialized region particularly known for iron industry. The remaining NTM species were M. fortuitum (16.6%), M. novocastrense (16.6%), M. chelonae (10.0%), M. gordonae (6.6%), M. gadium (6.6%), M. peregrinum (3.3%), M. porcinum (3.3%), and M. flavescens (3.3%). There were no bacteria of the M. avium complex, the most frequently isolated NTM globally, and the main driver of the rise of NTM-lung diseases. Conclusions This study uncovered an exceptional low prevalence of PNTM isolation among HIV-negative TB suspects in Northern Tunisia, suggesting a very low burden of NTM pulmonary disease. However, the frequent isolation of M. kansasii subtype 1, the most pathogenic subtype, particularly from the industrialized region of Bizerte, strongly suggests its effective involvement in a typical pulmonary disease.

Geographic Distribution of Nontuberculous Mycobacteria Isolated from Clinical Specimens: A Systematic Review

2018 ◽  
Vol 39 (03) ◽  
pp. 336-342 ◽  
Author(s):  
Sanne Zweijpfenning ◽  
Wouter Hoefsloot ◽  
Jakko Ingen
Keyword(s):  
Systematic Review ◽  
Clinical Practice ◽  
Pulmonary Disease ◽  
Nontuberculous Mycobacteria ◽  
Daily Clinical Practice ◽  
Multicenter Studies ◽  
Isolation Frequency ◽  
Microbiological Methods ◽  
Causative Agents ◽  
Isolated Species

AbstractIsolation frequency of nontuberculous mycobacterial (NTM) differs per region. Differences in isolation frequency as well as frequencies in clinical relevance are relevant for daily clinical practice. We conducted a systematic review, searching PubMed to assess these differences. Mycobacterium avium complex (MAC) is the most frequently isolated species and the majority of MAC isolates are causative agents of clinically relevant disease, that is, the patient ultimately meets American Thoracic Society/Infectious Disease Society of America diagnostic criteria for NTM pulmonary disease. Differences in isolation frequency between MAC species are seen in different continents. Another species that shows a remarkable difference in isolation frequency is M. abscessus complex, which is common in Asia and Oceania, in contrast to Europe, North America, and South America. Furthermore, differences in isolation frequency are seen between different continents, and also between regions or cities. These differences might drive local epidemiology of NTM pulmonary disease, and knowledge of the local situation is thus essential for daily clinical practice. To be fully able to assess this problem, larger multicenter studies with uniform microbiological methods are needed.

Sign in / Sign up

Export Citation Format

Share Document