Telavancin’s interactions with the bacterial cell membrane

2010 ◽  
Vol 5 (3) ◽  
pp. 355-358 ◽  
Author(s):  
Esteban C Nannini ◽  
Martin E Stryjewski ◽  
G Ralph Corey
Keyword(s):  
Cell Membrane ◽  
Bacterial Cell ◽  
Bacterial Cell Membrane

Design of bio-molecular interfaces using liquid crystals demonstrating endotoxin interactions with bacterial cell wall components

RSC Advances ◽  
2015 ◽  
Vol 5 (81) ◽  
pp. 66476-66486 ◽  
Author(s):  
Dibyendu Das ◽  
Sumyra Sidiq ◽  
Santanu Kumar Pal
Keyword(s):  
Cell Wall ◽  
Liquid Crystals ◽  
Cell Membrane ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Components ◽  
Bacterial Cell Membrane ◽  
Membrane Components ◽  
Wall Components

Liquid crystals offer a promising approach to study and quantify the interactions between different bacterial cell membrane components with endotoxin at an aqueous interface.

scholarly journals Telavancin, a Multifunctional Lipoglycopeptide, Disrupts both Cell Wall Synthesis and Cell Membrane Integrity in Methicillin-Resistant Staphylococcus aureus

2005 ◽  
Vol 49 (3) ◽  
pp. 1127-1134 ◽  
Author(s):  
Deborah L. Higgins ◽  
Ray Chang ◽  
Dmitri V. Debabov ◽  
Joey Leung ◽  
Terry Wu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Wall ◽  
Membrane Potential ◽  
Cell Membrane ◽  
Bactericidal Activity ◽  
Bacterial Cell ◽  
Cell Membrane Potential ◽  
Gram Positive ◽  
Methicillin Resistant ◽  
Bacterial Cell Membrane

ABSTRACTThe emergence and spread of multidrug-resistant gram-positive bacteria represent a serious clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in vitro bactericidal activity against a broad spectrum of clinically relevant gram-positive pathogens. Here we demonstrate that telavancin's antibacterial activity derives from at least two mechanisms. As observed with vancomycin, telavancin inhibited late-stage peptidoglycan biosynthesis in a substrate-dependent fashion and bound the cell wall, as it did the lipid II surrogate tripeptideN,N′-diacetyl-l-lysinyl-d-alanyl-d-alanine, with high affinity. Telavancin also perturbed bacterial cell membrane potential and permeability. In methicillin-resistantStaphylococcus aureus, telavancin caused rapid, concentration-dependent depolarization of the plasma membrane, increases in permeability, and leakage of cellular ATP and K+. The timing of these changes correlated with rapid , concentration-dependent loss of bacterial viability, suggesting that the early bactericidal activity of telavancin results from dissipation of cell membrane potential and an increase in membrane permeability. Binding and cell fractionation studies provided direct evidence for an interaction of telavancin with the bacterial cell membrane; stronger binding interactions were observed with the bacterial cell wall and cell membrane relative to vancomycin. We suggest that this multifunctional mechanism of action confers advantageous antibacterial properties.

4-Hydroxy-2-nonylquinoline: A Novel Iron Chelator Isolated from a Bacterial Cell Membrane

2001 ◽  
Vol 29 (6) ◽  
pp. 387-397 ◽  
Author(s):  
Paulette W. Royt ◽  
Robert V. Honeychuck ◽  
Vadim Ravich ◽  
Padma Ponnaluri ◽  
Lewis K. Pannell ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Bacterial Cell ◽  
Iron Chelator ◽  
Bacterial Cell Membrane

scholarly journals Nucleoid occlusion protein N oc recruits DNA to the bacterial cell membrane

2015 ◽  
Vol 34 (4) ◽  
pp. 491-501 ◽  
Author(s):  
David William Adams ◽  
Ling Juan Wu ◽  
Jeff Errington
Keyword(s):  
Cell Membrane ◽  
Bacterial Cell ◽  
Bacterial Cell Membrane
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