scholarly journals Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies

Epigenomics ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 877-879 ◽  
Author(s):  
Sébastien Lalevée ◽  
Robert Feil
Keyword(s):  
Human Disease ◽  
Noncoding Rnas ◽  
Therapeutic Strategies ◽  
Long Noncoding Rnas

Corrigendum: Long noncoding RNAs and human disease

2011 ◽  
Vol 21 (10) ◽  
pp. 561 ◽  
Author(s):  
Orly Wapinski ◽  
Howard Y. Chang
Keyword(s):  
Human Disease ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

ChemMedChem ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. 1932-1956 ◽  
Author(s):  
Arunoday Bhan ◽  
Subhrangsu S. Mandal
Keyword(s):  
Gene Regulation ◽  
Human Disease ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals A Computational Framework to Infer Human Disease-Associated Long Noncoding RNAs

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84408 ◽  
Author(s):  
Ming-Xi Liu ◽  
Xing Chen ◽  
Geng Chen ◽  
Qing-Hua Cui ◽  
Gui-Ying Yan
Keyword(s):  
Human Disease ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Computational Framework

scholarly journals Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets

2017 ◽  
Vol 42 (4) ◽  
pp. 1407-1419 ◽  
Author(s):  
Zhihong Li ◽  
Pengcheng Dou ◽  
Tang Liu ◽  
Shasha He
Keyword(s):  
Prognostic Biomarker ◽  
Noncoding Rnas ◽  
Therapeutic Targets ◽  
Therapeutic Strategies ◽  
Long Noncoding Rnas ◽  
Protein Coding ◽  
Rna Molecules ◽  
Primary Bone ◽  
Coding Potential ◽  
Potential Biomarkers

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and effective prognostic biomarker and therapeutic targets for the disease. Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts >200 nucleotides that lack protein coding potential. Many lncRNAs are deregulated in cancer and are important regulators for malignancies. Nine lncRNAs (91H, BCAR4, FGFR3-AS1, HIF2PUT, HOTTIP, HULC, MALAT-1, TUG1, UCA1) are upregulated and considered oncogenic for osteosarcoma. Loc285194 and MEG3 are two lncRNAs downregulated and as tumor suppressor for the disease. Moreover, the expressions of LINC00161 and ODRUL are associated with chemo-resistance of osteosarcoma. The mechanisms for these lncRNAs in regulating development of osteosarcoma are diverse, e.g. ceRNA, Wnt/β-catenin pathway, etc. The lncRNAs identified may serve as potential biomarkers or therapeutic targets for osteosarcoma.

Long noncoding RNAs and human disease

2011 ◽  
Vol 21 (6) ◽  
pp. 354-361 ◽  
Author(s):  
Orly Wapinski ◽  
Howard Y. Chang
Keyword(s):  
Human Disease ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas
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