Treatment options in obstructive sleep apnea

2014 ◽  
pp. 94-116
Author(s):  
Patrick Lévy ◽  
Jean-Louis Pépin ◽  
Renaud Tamisier ◽  
Sandrine Launois-Rollinat
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Treatment Options ◽  
Obstructive Sleep

Obstructive Sleep Apnea: An Overview of the Disorder, Consequences, and Treatment Options

2015 ◽  
Vol 1 (2) ◽  
pp. 37
Author(s):  
SameerPralhad Narkhede ◽  
Karthik Shetty ◽  
Sushma Sonawane ◽  
Nitin Gadhiya ◽  
VivekP Soni
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Treatment Options ◽  
Obstructive Sleep

scholarly journals Treatment of Obstructive Sleep Apnea in Children: Handling the Unknown with Precision

2020 ◽  
Vol 9 (3) ◽  
pp. 888 ◽  
Author(s):  
David Gozal ◽  
Hui-Leng Tan ◽  
Leila Kheirandish-Gozal
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Treatment Options ◽  
A Priori ◽  
Upper Airway ◽  
Surgical Removal ◽  
Low Grade ◽  
Maxillary Expansion ◽  
Obstructive Sleep ◽  
Anti Inflammatory

Treatment approaches to pediatric obstructive sleep apnea (OSA) have remarkably evolved over the last two decades. From an a priori assumption that surgical removal of enlarged upper airway lymphadenoid tissues (T&A) was curative in the vast majority of patients as the recommended first-line treatment for pediatric OSA, residual respiratory abnormalities are frequent. Children likely to manifest persistent OSA after T&A include those with severe OSA, obese or older children, those with concurrent asthma or allergic rhinitis, children with predisposing oropharyngeal or maxillomandibular factors, and patients with underlying medical conditions. Furthermore, selection anti-inflammatory therapy or orthodontic interventions may be preferable in milder cases. The treatment options for residual OSA after T&A encompass a large spectrum of approaches, which may be complementary, and clearly require multidisciplinary cooperation. Among these, continuous positive airway pressure (CPAP), combined anti-inflammatory agents, rapid maxillary expansion, and myofunctional therapy are all part of the armamentarium, albeit with currently low-grade evidence supporting their efficacy. In this context, there is urgent need for prospective evidence that will readily identify the correct candidate for a specific intervention, and thus enable some degree of scientifically based precision in the current one approach fits all model of pediatric OSA medical care.

scholarly journals Obstructive Sleep Apnea in a Patient with CHARGE Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Carrie-Lee Trider ◽  
Kim Blake
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cranial Nerve ◽  
Genetic Disorder ◽  
Treatment Options ◽  
Choanal Atresia ◽  
Charge Syndrome ◽  
Physical Symptoms ◽  
Obstructive Sleep

CHARGE syndrome is a genetic disorder characterized by choanal atresia, coloboma of the eye, and ear and cranial nerve abnormalities. We report a child with CHARGE syndrome and obstructive sleep apnea. We highlight difficulties in discerning obstructive sleep apnea-related symptoms from typical features of CHARGE syndrome. Treatment options are discussed with regard to our patient. Tonsillectomy and adenoidectomy improved physical symptoms of obstructive sleep apnea in the patient.

A MODEL TO FACILITATE OUTCOME ASSESSMENT OF OBSTRUCTIVE SLEEP APNEA

2003 ◽  
Vol 19 (1) ◽  
pp. 253-260 ◽  
Author(s):  
Seema S. Sonnad ◽  
Cheryl A. Moyer ◽  
Shushma Patel ◽  
Joseph I. Helman ◽  
Susan L. Garetz ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cost Effectiveness ◽  
Sleep Apnea ◽  
Treatment Plan ◽  
Treatment Options ◽  
Surgical Approaches ◽  
Management Options ◽  
Initial Cost ◽  
Limited Effectiveness ◽  
Obstructive Sleep

Objectives: Obstructive sleep apnea is a common disorder with significant morbidity and effects on quality of life. Management can include a range of mechanical, behavioral, and surgical approaches. This paper aims to devise a model of management options to assist in initial cost-effectiveness investigations.Methods: In the absence of practice pattern data and widely accepted guidelines, we reviewed published literature and devised a model of treatment options to facilitate initial studies of outcomes, costs, and cost-effectiveness.Results: Obstructive sleep apnea is rarely addressed by conservative behavioral-based strategies because these options, while inexpensive, have only limited effectiveness. Effective treatment most often relies on nasal continuous positive airway pressure, but poor tolerance or compliance sometimes leads to treatment with oral appliances or surgery. Patients treated by one modality may try another if the initial strategy is ineffective. Laboratory evidence that sleep apnea is effectively treated, and long-term follow-up, are necessary regardless of the treatment modality chosen.Conclusions: Each patient's treatment plan must be individually tailored, but the management model proposed here reflects available evidence-based literature and the authors' impression of current practice patterns. This model should be useful for initial cost-effectiveness investigations.

scholarly journals A Review of the Surgical Treatment Options for the Obstructive Sleep Apnea/Hypopnea Syndrome Patient

2010 ◽  
Vol 175 (9) ◽  
pp. 676-685 ◽  
Author(s):  
David B. Powers ◽  
Patrick F. Allan ◽  
Curtis J. Hayes ◽  
Peter G. Michaelson
Keyword(s):  
Obstructive Sleep Apnea ◽  
Surgical Treatment ◽  
Sleep Apnea ◽  
Treatment Options ◽  
Syndrome Patient ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

scholarly journals Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease: Lessons from Animal Studies

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rio Dumitrascu ◽  
Joerg Heitmann ◽  
Werner Seeger ◽  
Norbert Weissmann ◽  
Richard Schulz
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Animal Models ◽  
Arterial Hypertension ◽  
Animal Studies ◽  
Treatment Options ◽  
Free Oxygen Radicals ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular (CV) diseases such as arterial hypertension, heart failure, and stroke. Based on human research, sympathetic activation, inflammation, and oxidative stress are thought to play major roles in the pathophysiology of OSA-related CV diseases. Animal models of OSA have shown that endothelial dysfunction, vascular remodelling, and systemic and pulmonary arterial hypertension as well as heart failure can develop in response to chronic intermittent hypoxia (CIH). The available animal data are clearly in favour of oxidative stress playing a key role in the development of all of these CV manifestations of OSA. Presumably, the oxidative stress is due to an activation of NADPH oxidase and other free oxygen radicals producing enzymes within the CV system as evidenced by data from knockout mice and pharmacological interventions. It is hoped that animal models of OSA-related CV disease will continue to contribute to a deeper understanding of their underlying pathophysiology and will foster the way for the development of cardioprotective treatment options other than conventional CPAP therapy.

Oral appliances for the treatment of snoring and obstructive sleep apnea

2000 ◽  
Vol 122 (2) ◽  
pp. 259-262 ◽  
Author(s):  
Scott R. Schoem
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Historical Development ◽  
Treatment Options ◽  
Oral Appliances ◽  
Clinical Testing ◽  
Efficacy And Safety ◽  
Ongoing Debate ◽  
Regulatory Issues ◽  
Obstructive Sleep

Oral appliances have been used by dentists for several decades to treat snoring and obstructive sleep apnea. Although these devices are regulated by the Food and Drug Administration, most have undergone only sparse clinical testing for efficacy and safety. Most otolaryngologists are not well-versed in their applicability as treatment options. This review summarizes the historical development of oral appliances, the types of available devices, the current literature regarding devices, and pertinent regulatory issues as they relate to the ongoing debate over appliance use and potential misuse.

scholarly journals An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment

2021 ◽  
Vol 8 ◽  
Author(s):  
Jin Chen ◽  
Shu Lin ◽  
Yiming Zeng
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Intermittent Hypoxia ◽  
Best Practice ◽  
Vascular Dysfunction ◽  
Treatment Options ◽  
Underlying Mechanism ◽  
Diagnosis And Treatment ◽  
Mandibular Advancement ◽  
Obstructive Sleep

The occurrence and development of atherosclerosis could be influenced by intermittent hypoxia. Obstructive sleep apnea (OSA), characterized by intermittent hypoxia, is world-wide prevalence with increasing morbidity and mortality rates. Researches remain focused on the study of its mechanism and improvement of diagnosis and treatment. However, the underlying mechanism is complex, and the best practice for OSA diagnosis and treatment considering atherosclerosis and related cardiovascular diseases is still debatable. In this review, we provided an update on research in OSA in the last 5 years with regard to atherosclerosis. The processes of inflammation, oxidative stress, autonomic nervous system activation, vascular dysfunction, platelet activation, metabolite dysfunction, small molecule RNA regulation, and the cardioprotective occurrence was discussed. Additionally, improved diagnosis such as, the utilized of portable device, and treatment especially with inconsistent results in continuous positive airway pressure and mandibular advancement devices were illustrated in detail. Therefore, further fundamental and clinical research should be carried out for a better understanding the deep interaction between OSA and atherosclerosis, as well as the suggestion of newer diagnostic and treatment options.

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