Management of the node-negative neck in early-stage nasopharyngeal carcinoma

2014 ◽  
pp. 97-110
Author(s):  
Francis CH Ho ◽  
Jiade J Lu
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Stage ◽  
Node Negative

scholarly journals De-escalation of radiation therapy in patients with stage I, node-negative, HER2-positive breast cancer

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jose G. Bazan ◽  
Sachin R. Jhawar ◽  
Daniel Stover ◽  
Ko Un Park ◽  
Sasha Beyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Local Therapy ◽  
Adjuvant Radiation ◽  
Her2 Positive ◽  
Node Negative ◽  
Risk Of Death ◽  
Her2 Breast Cancer ◽  
Neoadjuvant Systemic Therapy ◽  
Increased Risk

AbstractIn the modern era, highly effective anti-HER2 therapy is associated with low local-regional recurrence (LRR) rates for early-stage HER2+ breast cancer raising the question of whether local therapy de-escalation by radiation omission is possible in patients with small-node negative tumors treated with lumpectomy. To evaluate existing data on radiation omission, we used the National Cancer Database (NCDB) to test the hypothesis that RT omission results in equivalent overall survival (OS) in stage 1 (T1N0) HER2+ breast cancer. We excluded patients that received neoadjuvant systemic therapy. We stratified the cohort by receipt of adjuvant radiation. We identified 6897 patients (6388 RT; 509 no RT). Patients that did not receive radiation tended to be ≥70 years-old (odds ratio [OR] = 3.69, 95% CI: 3.02–4.51, p < 0.0001), to have ≥1 comorbidity (OR = 1.33, 95% CI: 1.06–1.68, p = 0.0154), to be Hispanic (OR = 1.49, 95% CI: 1.00–2.22, p = 0.049), and to live in lower income areas (OR = 1.32, 95% CI: 1.07–1.64, p = 0.0266). Radiation omission was associated with a 3.67-fold (95% CI: 2.23–6.02, p < 0.0001) increased risk of death. While other selection biases that influence radiation omission likely persist, these data should give caution to radiation omission in T1N0 HER2+ breast cancer.

scholarly journals Genomic Profile of Early Stage Node-Negative Luminal Breast Cancer Associated with Short Disease-Specific Survival

2014 ◽  
Vol 25 ◽  
pp. iv95
Author(s):  
A. Durigova ◽  
P. Tsantoulis ◽  
R. Lyle ◽  
C. Borel ◽  
G. Fioretta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Luminal Breast Cancer ◽  
Genomic Profile ◽  
Disease Specific Survival ◽  
Node Negative ◽  
Disease Specific

scholarly journals EP-1921: Dosimetric study of neck skin dose for early-stage nasopharyngeal carcinoma

2018 ◽  
Vol 127 ◽  
pp. S1044
Author(s):  
X.F. Liao ◽  
J. Li ◽  
L.C. Orlandini ◽  
P. Xu ◽  
C. Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Stage ◽  
Skin Dose ◽  
Dosimetric Study

MDM2 amplification is an independent prognostic feature of node-negative, estrogen receptor-positive early-stage breast cancer

2011 ◽  
Vol 8 (2) ◽  
pp. 53-60 ◽  
Author(s):  
Matthias Choschzick ◽  
Uwe Heilenkötter ◽  
Annette Lebeau ◽  
Fritz Jaenicke ◽  
Luigi Terracciano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Node Negative ◽  
Estrogen Receptor Positive ◽  
Prognostic Feature ◽  
Mdm2 Amplification

Possible available treatment option for early stage, small, node-negative, and HER2-overexpressing breast cancer

Breast Cancer ◽  
2011 ◽  
Vol 19 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Kazuhiro Araki ◽  
Shigehira Saji ◽  
Michelle Gallas ◽  
Mark Pegram ◽  
Yasutsuna Sasaki
Keyword(s):  
Breast Cancer ◽  
Treatment Option ◽  
Early Stage ◽  
Node Negative
Sign in / Sign up

Export Citation Format

Share Document