Ask the Experts: Parkinson’s disease treatment pipelines

2013 ◽  
pp. 139-148
Author(s):  
Joseph Jankovic
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Treatment

scholarly journals Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment

2021 ◽  
Author(s):  
Junmei Shang ◽  
Shurong Ma ◽  
Caixia Zang ◽  
Xiuqi Bao ◽  
Yan Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Disease Treatment ◽  
New Drug

scholarly journals Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10385-10392
Author(s):  
Dong-Fang Zhao ◽  
Yu-Fan Fan ◽  
Fang-Yuan Wang ◽  
Fan-Bin Hou ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicines ◽  
Disease Treatment ◽  
Naturally Occurring

Discovery and characterization of natural human catechol-O-methyltransferase (hCOMT) inhibitors for Parkinson's disease treatment.

Gold nanoclusters for Parkinson's disease treatment

Biomaterials ◽  
2019 ◽  
Vol 194 ◽  
pp. 36-46 ◽  
Author(s):  
Guanbin Gao ◽  
Rui Chen ◽  
Meng He ◽  
Jing Li ◽  
Jing Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gold Nanoclusters ◽  
Disease Treatment

Neuropsychiatric effects of Parkinson's disease treatment

2012 ◽  
Vol 31 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Sallyanne Aarons ◽  
Carmelle Peisah ◽  
Chanaka Wijeratne
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Treatment

scholarly journals Apomorphine in the treatment of Parkinson's disease: a review

2018 ◽  
Vol 76 (12) ◽  
pp. 840-848 ◽  
Author(s):  
Renata Ramina Pessoa ◽  
Adriana Moro ◽  
Renato Puppi Munhoz ◽  
Hélio A.G. Teive ◽  
Andrew J. Lees
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rescue Therapy ◽  
Continuous Process ◽  
Subcutaneous Administration ◽  
Historical Background ◽  
Infusion Therapy ◽  
Disease Treatment ◽  
Positive Effects

ABSTRACT Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients’ quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects on nonmotor symptoms, is the only antiparkinsonian agent whose capacity to control motor symptoms is comparable to that of levodopa. Subcutaneous administration, either as an intermittent injection or as continuous infusion, appears to be the most effective and tolerable route. This review summarizes the historical background, structure, mechanism of action, indications, contraindications and side effects, compares apomorphine infusion therapy with other treatments, such as oral therapy, deep brain stimulation and continuous enteral infusion of levodopa/carbidopa gel, and gives practical instructions on how to initiate treatment.

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