Molecular markers in radically resected colorectal cancer: from prognosis to prediction

2013 ◽  
pp. 48-58
Author(s):  
Wu Zhang ◽  
Peter M Wilson ◽  
Sebastian Stintzing ◽  
Heinz-Josef Lenz
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers

Molecular Markers for Colorectal Cancer

Swiss Surgery ◽  
2001 ◽  
Vol 7 (6) ◽  
pp. 243-248
Author(s):  
Scheunemann ◽  
Hosch ◽  
Kutup ◽  
Izbicki
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Prospektive Studien ◽  
Therapeutische Konsequenzen

Die Einführung von immunhisto-/zytochemischen und molekularbiologischen bzw. zytogenetischen Methoden in der onkologische Forschung hat trotz vieler nach wie vor bestehender offener Fragen insgesamt zu einem besseren Verständnis der genetischen Ursachen der Tumorentstehung geführt. Darüber hinaus ergaben sich in verschiedenen Studien Hinweise für eine prognostische Relevanz von bestimmten (zyto)genetischen Veränderungen bzw. residualen Tumorzellen in Lymphknoten oder Knochenmark. Bevor diese Untersuchungen jedoch in den klinischen Alltag Einzug halten und therapeutische Konsequenzen abgeleitet werden können, sind weitere prospektive Studien mit groáen Patientenfallzahlen sowie vereinheitlichte und methodologisch praktikable Untersuchungstechniken zu fordern.

Molecular markers and the future of colorectal cancer screening

2013 ◽  
Vol 2 (2) ◽  
pp. 95-97
Author(s):  
Beatriz Carvalho ◽  
Linda JW Bosch ◽  
Manon Van Engeland ◽  
Gerrit A Meijer
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
The Future

scholarly journals Fecal Molecular Markers for Colorectal Cancer Screening

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Rani Kanthan ◽  
Jenna-Lynn Senger ◽  
Selliah Chandra Kanthan
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Cost Effective ◽  
Occult Blood ◽  
Fecal Occult Blood Testing ◽  
Premalignant Lesions ◽  
Fecal Occult Blood ◽  
Noninvasive Technique ◽  
Fecal Matter ◽  
Incidence And Mortality

Despite multiple screening techniques, including colonoscopy, flexible sigmoidoscopy, radiological imaging, and fecal occult blood testing, colorectal cancer remains a leading cause of death. As these techniques improve, their sensitivity to detect malignant lesions is increasing; however, detection of precursor lesions remains problematic and has generated a lack of general acceptance for their widespread usage. Early detection by an accurate, noninvasive, cost-effective, simple-to-use screening technique is central to decreasing the incidence and mortality of this disease. Recent advances in the development of molecular markers in faecal specimens are encouraging for its use as a screening tool. Genetic mutations and epigenetic alterations that result from the carcinogenetic process can be detected by coprocytobiology in the colonocytes exfoliated from the lesion into the fecal matter. These markers have shown promising sensitivity and specificity in the detection of both malignant and premalignant lesions and are gaining popularity as a noninvasive technique that is representative of the entire colon. In this paper, we summarize the genetic and epigenetic fecal molecular markers that have been identified as potential targets in the screening of colorectal cancer.

scholarly journals Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies

2018 ◽  
Vol 59 (5-6) ◽  
pp. 361-370 ◽  
Author(s):  
Pridvi Kandagatla ◽  
Lilias H. Maguire ◽  
Karin M. Hardiman
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Molecular Markers ◽  
Lymph Node ◽  
Genetic Heterogeneity ◽  
Genetic Studies ◽  
Potential Models ◽  
Node Metastasis ◽  
Node Metastases ◽  
Nodal Spread

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

3002 ORAL Comprehensive assessment of molecular markers predicting response to cetuximab therapy in colorectal cancer

2007 ◽  
Vol 5 (4) ◽  
pp. 235
Author(s):  
F. Cappuzzo ◽  
G. Finocchiaro ◽  
P.A. Janne ◽  
W.A. Franklin ◽  
K. Bencardino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Comprehensive Assessment ◽  
Cetuximab Therapy

scholarly journals Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Gaia Peluso ◽  
Paola Incollingo ◽  
Armando Calogero ◽  
Vincenzo Tammaro ◽  
Niccolò Rupealta ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Molecular Markers ◽  
Ct Colonography ◽  
Precancerous Lesions ◽  
Therapeutic Process ◽  
Cost Effective ◽  
Screening Tests ◽  
Endoscopic Evaluation ◽  
The World

Background. Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic.Aim of the Review. Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC.Conclusion. Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.

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