Emerging therapeutics and future direction

An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so, the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West.

Download Full-text

Ketamine Treatment in Depression: A Systematic Review of Clinical Characteristics Predicting Symptom Improvement

Current Topics in Medicinal Chemistry ◽

10.2174/1568026620666200423094423 ◽

2020 ◽

Vol 20 (15) ◽

pp. 1398-1414 ◽

Cited By ~ 2

Author(s):

Darby J.E. Lowe ◽

Daniel J. Müller ◽

Tony P. George

Keyword(s):

Clinical Features ◽

Clinical Characteristics ◽

Bipolar Depression ◽

Antidepressant Effect ◽

Future Research ◽

Symptom Improvement ◽

Randomized Controlled ◽

Treatment Of Depression ◽

Future Direction

Ketamine has been shown to be efficacious for the treatment of depression, specifically among individuals who do not respond to first-line treatments. There is still, however, a lack of clarity surrounding the clinical features and response periods across samples that respond to ketamine. This paper systematically reviews published randomized controlled trials that investigate ketamine as an antidepressant intervention in both unipolar and bipolar depression to determine the specific clinical features of the samples across different efficacy periods. Moreover, similarities and differences in clinical characteristics associated with acute versus longer-term drug response are discussed. Similarities across all samples suggest that the population that responds to ketamine’s antidepressant effect has experienced chronic, long-term depression, approaching ketamine treatment as a “last resort”. Moreover, differences between these groups suggest future research to investigate the potential of stronger efficacy towards depression in the context of bipolar disorder compared to major depression, and in participants who undergo antidepressant washout before ketamine administration. From these findings, suggestions for the future direction of ketamine research for depression are formed.

Download Full-text

A Comprehensive Analysis of Image Forensics Techniques: Challenges and future Direction

Recent Patents on Engineering ◽

10.2174/1872212113666190722143334 ◽

2019 ◽

Vol 13 ◽

Cited By ~ 3

Author(s):

Mohd Dilshad Ansari ◽

Ekbal Rashid ◽

S Siva Skandha ◽

Suneet Kumar Gupta

Keyword(s):

Image Forensics ◽

Digital Era ◽

Current State ◽

Benchmark Datasets ◽

Passive Authentication ◽

Prime Objective ◽

Future Direction ◽

Source Of Information ◽

Research Domain ◽

Open Issues

Background: image forensics deal with the problem of authentication of pictures or their origins. There are two types of forensics techniques namely active and passive. Passive forgery is also known as blind forensics technique. In passive forgery, copy-move (cloning) image forensics is most common forgery technique. In this approach, an object or region of a picture is copied and positioned somewhere else in the same image. Active method used watermarking to solve picture genuineness problem. It has limitations like human involvement or particularly equipped cameras. To overwhelm these limitations, numerous passive authentication approaches have been developed. Moreover, both approaches do not require any prior information about the picture. Objective: The prime objective of this survey is to provide an inclusive summary as well as recent advancement, challenges and future direction in image forensics. In Today’s digital era the digital pictures and videos are having great impact on our life as well as society, as they became the important source of information. Though earlier it was very difficult to doctor the picture, nowadays digital pictures can be doctored easily with the help of editing tools and internet. These practices make pictures as well as videos genuineness deceptive. Conclusion: This paper presents the current state-of- the-art of passive (cloning) image forensics techniques, challenges and future direction of this research domain. Further, the major open issues in developing a robust cloning image forensics detector with their performance are discussed. Lastly, the available benchmark datasets are also discussed

Download Full-text