Novel targets and therapies in COPD

2012 ◽  
pp. 104-120
Author(s):  
Peter J Barnes
Keyword(s):  
Novel Targets

Novel targets for the treatment of ACTH-secreting tumors

2006 ◽  
Vol 114 (08) ◽  
Author(s):  
M Labeur ◽  
M Paez-Pereda ◽  
M Theodoropoulou ◽  
J Stalla ◽  
B Woelfel ◽  
...  
Keyword(s):  
Novel Targets ◽  
Acth Secreting

Astrocytes in health and disease

2007 ◽  
Vol 148 (15) ◽  
pp. 697-702 ◽  
Author(s):  
Marianna Murányi ◽  
Zsombor Lacza
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Free Radicals ◽  
Molecular Mechanisms ◽  
Neuronal Dysfunction ◽  
Supporting Cells ◽  
Neuronal Synapses ◽  
Health And Disease ◽  
Novel Targets ◽  
Therapeutic Tools

It is now known that astrocytes are not merely supporting cells but they also play an important role in neuronal funcions. Astrocytes tightly ensheat neuronal synapses and regulate the excitation of neurons by uptaking neurotransmitters; reglulate the cerebral blood flow, cerebral fluid volume and extracellular concentrations of ions. They also supply fuel in the form of lactate and provide free radical scavangers such as glutathione for active neurons. These facts indicate that impaired function of astrocytes may lead to neuronal dysfunction. After brain injury (stroke, trauma or tumors) astrocytes are swollen and release active molecules such as glutamate or free radicals resulting in neuronal dysfunction. Thus, investigation of the molecular mechanisms of astrocyte function may reveal novel targets for the development of therapeutic tools in neuronal diseases.

Novel Targets of Vitamin D Activity in Bone: Action of the Vitamin D Receptor in Osteoblasts, Osteocytes and Osteoclasts

2013 ◽  
Vol 14 (14) ◽  
pp. 1683-1688 ◽  
Author(s):  
Jackson Ryan ◽  
Daniel Reinke ◽  
Masakazu Kogawa ◽  
Andrew Turner ◽  
Gerald Atkins ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Novel Targets

Therapeutic Targets for the Treatment of Comorbidities Associated with Epilepsy

2020 ◽  
Vol 13 (2) ◽  
pp. 85-93
Author(s):  
Kinjal Gangar ◽  
Lokesh Kumar Bhatt
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Neurological Disorders ◽  
Therapeutic Targets ◽  
Therapeutic Failure ◽  
Hyperactivity Disorder ◽  
Novel Targets ◽  
New Therapeutic Targets ◽  
Dual Mechanism ◽  
Seizure Suppression

One of the most common neurological disorders, which occurs among 1% of the population worldwide, is epilepsy. Therapeutic failure is common with epilepsy and nearly about 30% of patients fall in this category. Seizure suppression should not be the only goal while treating epilepsy but associated comorbidities, which can further worsen the condition, should also be considered. Treatment of such comorbidities such as depression, anxiety, cognition, attention deficit hyperactivity disorder and, various other disorders which co-exist with epilepsy or are caused due to epilepsy should also be treated. Novel targets or the existing targets are needed to be explored for the dual mechanism which can suppress both the disease and the comorbidity. New therapeutic targets such as IDO, nNOS, PAR1, NF-κb are being explored for their role in epilepsy and various comorbidities. This review explores recent therapeutic targets for the treatment of comorbidities associated with epilepsy.

scholarly journals Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy

2015 ◽  
Vol 150 ◽  
pp. 54-63 ◽  
Author(s):  
Xia Ren ◽  
Xuan Wu ◽  
Stephen G. Hillier ◽  
K. Scott Fegan ◽  
Hilary O.D. Critchley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Estrogen Metabolism ◽  
Novel Targets
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