Hormone treatment for prostate cancer

2011 ◽  
pp. 46-52
Author(s):  
Janusz Mezynski ◽  
Johann De Bono
Keyword(s):  
Prostate Cancer ◽  
Hormone Treatment

Anti-hormone Treatment for Prostate Cancer Relapsing after Treatment with Flutamide and Castration

1989 ◽  
Vol 63 (6) ◽  
pp. 634-638 ◽  
Author(s):  
F. LABRIE ◽  
A. DUPONT ◽  
A. BÉLANGER ◽  
L. CUSAN ◽  
M. BROCHU ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hormone Treatment

scholarly journals Phase III Trial of Androgen Ablation With or Without Three Cycles of Systemic Chemotherapy for Advanced Prostate Cancer

2008 ◽  
Vol 26 (36) ◽  
pp. 5936-5942 ◽  
Author(s):  
Randall E. Millikan ◽  
Sijin Wen ◽  
Lance C. Pagliaro ◽  
Melissa A. Brown ◽  
Brenda Moomey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Standard Therapy ◽  
Metastatic Prostate Cancer ◽  
Specific Antigen ◽  
Hormone Treatment ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Androgen Ablation ◽  
Castrate Resistant

Purpose We conducted a phase III trial in patients with previously untreated metastatic prostate cancer to test the hypothesis that three 8-week cycles of ketoconazole and doxorubicin alternating with vinblastine and estramustine, given in addition to standard androgen deprivation, would delay the appearance of castrate-resistant disease. Patients and Methods Eligible patients had metastatic prostate cancer threatening enough to justify sustained androgen ablation and were fit enough for chemotherapy. The primary end point was time to castrate-resistant progression as shown by increasing prostate-specific antigen, new radiographic lesions, worsening cancer-related symptoms, or receipt of any other systemic therapy. Results Three hundred six patients were registered; 286 are reported. Median time to progression was 24 months (95% CI, 18 to 39 months) in the standard therapy arm, and 35 months (95% CI, 26 to 44 months) in the chemohormonal group (P = .39). At median follow-up of 6.4 years, overall survival was 5.4 years (95% CI, 4.7 to 7.8 years) in the standard therapy arm versus 6.1 years (95% CI, 5.1 to 10.1 years; P = .41). Prostate-specific antigen kinetics at the time of androgen ablation and the nadir after hormone treatment were strongly correlated with survival. Chemotherapy significantly increased the burden of therapy, with 51% of patients experiencing an adverse event of grade 3 or worse, especially thromboembolic events. Conclusion There is no role for ketoconazole and doxorubicin alternating with vinblastine and estramustine before emergence of a castrate-resistant phenotype.

scholarly journals Phase I trial of TAK‐385 in hormone treatment‐naïve Japanese patients with nonmetastatic prostate cancer

2019 ◽  
Vol 8 (13) ◽  
pp. 5891-5902 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Hiroji Uemura ◽  
Atsushi Mizokami ◽  
Narihiko Hayashi ◽  
Yasuhide Miyoshi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Phase I ◽  
Phase I Trial ◽  
Japanese Patients ◽  
Hormone Treatment ◽  
Treatment Naïve
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