The association between hypovitaminosis D and metabolic syndrome: current understanding

2015 ◽  
Vol 10 (6) ◽  
pp. 513-524 ◽  
Author(s):  
Inka Miñambres ◽  
Jose Luís Sanchez-Quesada ◽  
Antonio Pérez
Keyword(s):  
Metabolic Syndrome ◽  
Hypovitaminosis D ◽  
Current Understanding

Vitamin D status and its associations with components of metabolic syndrome in healthy children

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Ali Awsat Mellati ◽  
Faranak Sharifi ◽  
Soghrat Faghihzade ◽  
Seyed Akbar Mousaviviri ◽  
Hosain Chiti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Resistance Index ◽  
Sun Exposure ◽  
Hypovitaminosis D ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Low Serum

AbstractHigh prevalence of vitamin D insufficiency/deficiency has been reported in populations of different countries. The aim of this cross-sectional study was to determine the prevalence and association of vitamin D status with components of metabolic syndrome.Lipid profile indices, anthropometric indices [body mass index and waist circumference (WC)], insulin resistance index (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein, intact parathyroid hormone (iPTH), and serum 25-hydroxyvitamin D [25(OH)D] concentration were evaluated in 297 healthy schoolchildren aged 7–11 years. Multivariate linear regression was used to determine independent predictors associated with low serum 25(OH)D concentrations.The mean serum 25(OH)D concentration was 14.12±8.20 ng/mL (35.3±20.5 nmol/L); 96% of children had low serum 25(OH)D levels, 31.0% were deficient, and 65.0% had insufficient levels of 25(OH)D. Vitamin D deficiency was higher in girls (χThe prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications.

scholarly journals The Association of Hypovitaminosis D with the Metabolic Syndrome Is Independent of the Degree of Obesity

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Inka Miñambres ◽  
Joan Sánchez-Hernández ◽  
Jose Luis Sánchez-Quesada ◽  
Jose Rodríguez ◽  
Alberto de Leiva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Hypovitaminosis D ◽  
Cross Sectional Survey ◽  
Chi Square ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
The Metabolic Syndrome ◽  
Chi Square Test ◽  
The Mean

Background. It remains uncertain whether the metabolic syndrome (MS) or insulin resistance contribute to the association between vitamin D deficiency and obesity. Methods. We conducted a cross-sectional survey of 343 subjects who were overweight or obese. We analyzed anthropometric data and the presence or absence of MS. Additionally, we determined 25-hydroxyvitamin D (25OHD) and insulin concentrations, and the HOMA index was calculated. Chi-square test,Mann-Whitney U test, Student's t-tests,and logistic regression analysis were used. Results. The mean age of the patients was 42±11 years, and 65.9% were women. The mean BMI was 34.7±8.3 kg/m2 and 25(OH)D levels were 53.7±29.8 nmol/L. Forty-six patients (13.4%) had MS. Vitamin D status was associated with the degree of obesity, especially with a BMI > 40 kg/m2. Patients with MS had lower levels of 25(OH)D than patients without (43.3±29.0 versus 55.3±29.6 mmol/L, resp.), and the odds ratio for hypovitaminosis D was 2.7 (confidence interval (CI), 1.14–6.4) (P=.023) for patients with MS versus patients without MS, irrespective of the degree of obesity. Conclusions. Our data confirm the association between vitamin D and MS and suggest that this association is independent of the degree of obesity.

scholarly journals Extraskeletal effects of vitamin D

2011 ◽  
Vol 2 (2) ◽  
pp. 87-100
Author(s):  
Maurizio Rossini
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Response To Therapy ◽  
Vitamin D Metabolites ◽  
Upper Respiratory Tract ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Tract Infections

In the last years we observed an increasing number of publications about the vitamin D, due to its recognised therapeutic actions and to the widespread hypovitaminosis D. In addition to the well known skeletal benefits, vitamin D can have multiple effects on other tissues.Muscular apparatus: hypovitaminosis D is associated with myopathy, sarcopenia, muscular strength reduction and increased risk of falls. The vitamin D supplementation increases the muscle functionality indexes. Cardiovascular system: low levels of vitamin D are related to increased levels of cardiovascular risk factors, heart failure, stroke, and cardiovascular mortality, while a good vitamin D status is associated with a decreased incidence of cardiovascular diseases. Diabetes and metabolic syndrome: a good vitamin D status is related to a decreased incidence of type 2 diabetes and metabolic syndrome; a vitamin D supplementation in the early childhood reduces (nearly 30%) the risk of having type 1 diabetes. Cancer: vitamin D deficit is associated with breast, colorectal cancer and melanoma relapses. Low and high levels of 25-hydroxy-vitamin D (25(OH)D) are related to a higher neoplastic mortality. Infectious diseases: hypovitaminosis D is associated with higher incidence of upper respiratory tract infections and worse interferon response in chronic hepatitis C. Vitamin D supplementation decreases the risk of having type A influence. Rheumatic diseases: in rheumatoid arthritis low serum levels of vitamin D metabolites are related to a higher disease activity, while a good vitamin D status is associated with a higher probability of remission or response to therapy and a lower degree of disability. Neurologic diseases: associations between vitamin D deficit and risk of multiple sclerosis, depression, cognitive deficits, and Parkinson’s disease have been reported.There is evidence of the extraskeletal effects of vitamin D, but most derive from observational studies: clinical trials are required the better to determine the therapeutic role of vitamin D.

scholarly journals Hypovitaminosis D is Independently Associated with Metabolic Syndrome in Obese Patients

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68689 ◽  
Author(s):  
Ilaria Barchetta ◽  
Marzia De Bernardinis ◽  
Danila Capoccia ◽  
Marco Giorgio Baroni ◽  
Mario Fontana ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Hypovitaminosis D ◽  
Obese Patients

scholarly journals Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Kenichi Matsushita
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Severe Obesity ◽  
Current Understanding ◽  
Clinical Implications ◽  
Future Studies ◽  
Global Epidemic ◽  
Major Factors ◽  
The Relationship

Metabolic syndrome is an obesity-based, complicated clinical condition that has become a global epidemic problem with a high associated risk for cardiovascular disease and mortality. Dyslipidemia, hypertension, and diabetes or glucose dysmetabolism are the major factors constituting metabolic syndrome, and these factors are interrelated and share underlying pathophysiological mechanisms. Severe obesity predisposes individuals to metabolic syndrome, and recent data suggest that mesenchymal stem cells (MSCs) contribute significantly to adipocyte generation by increasing the number of adipocytes. Accordingly, an increasing number of studies have examined the potential roles of MSCs in managing obesity and metabolic syndrome. However, despite the growing bank of experimental and clinical data, the efficacy and the safety of MSCs in the clinical setting are still to be optimized. It is thus hoped that ongoing and future studies can elucidate the roles of MSCs in metabolic syndrome and lead to MSC-based therapeutic options for affected patients. This review discusses current understanding of the relationship between MSCs and metabolic syndrome and its potential implications for patient management.

Vitamin D Supplementation in Adults with Vitamin D Deficiency and Its Effect on Metabolic Syndrome – A Randomized Controlled Study

2016 ◽  
Vol 86 (3-4) ◽  
pp. 121-126 ◽  
Author(s):  
Saba Fathima Mahmood ◽  
Jyothi Idiculla ◽  
Rajnish Joshi ◽  
Shailesh Joshi ◽  
Shruthi Kulkarni
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Placebo Group ◽  
Large Population ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Controlled Study ◽  
Model Assessment ◽  
Serum Vitamin D

Background: Inverse relationship between metabolic syndrome (MetS) and 25-hydroxyvitamin D (25(OH) D) levels is controversial. Hypovitaminosis-D has long been suspected as a risk factor for glucose intolerance. Aim: A randomized double blind placebo controlled study to evaluate effects of vitamin D supplementation on insulin resistance in subjects with hypovitaminosis-D and MetS. Materials and Methods: Subjects were randomized to receive either oral 25(OH) D3 supplement (60000 (IU) per week for 8 weeks followed by 60,000 IU monthly for 4 months) or a placebo for six months. The parameters measured were blood pressure, vitamin D, fasting blood sugar (FBS), insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI), body mass index (BMI), and waist circumference (WC). Results: There were no significant changes in parameters of vitamin-D group compared to placebo group except serum vitamin-D was significantly increased in vitamin-D group (p < 0.0001). In vitamin-D group, mean WC at baseline was 95.9 ± 6.66, which significantly changed to 94.6 ± 7.47 (p = 0.001). Mean BMI at baseline was 29.1 ± 4.06 which significantly changed to 28.5 ± 4.16 (p = 0.001). The mean vitamin-D concentration at baseline was 15.4 ± 9.03 which significantly (p < .0001) increased to 26.1 ± 11.8. In placebo group mean insulin levels was 10.7 ± 4.81IU / L which increased significantly (p = 0.03) to 15.4 ± 14.0. Mean QUICKI at baseline was 0.34 ± 0.03 which decreased significantly (p = 0.02) to 0.32 ± 0.03. Conclusion: In this study the relationship between vitamin D supplementation and MetS or IR was not established. Whether achieving vitamin D sufficiency in large population-based trials with a longer duration would produce more favorable results needs to be assessed.

PREVALENCE OF METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS (LITERATURE REVIEW)

Vestnik ◽  
2021 ◽  
pp. 78-80
Author(s):  
А.Б. Альмуханова ◽  
А.Е. Раисова ◽  
Н.Р. Зайнутдинова ◽  
Ф.А. Зинбай
Keyword(s):  
Metabolic Syndrome ◽  
Literature Review ◽  
Children And Adolescents ◽  
Current Understanding ◽  
The Metabolic Syndrome

Данный литературный обзор посвящен распространенности метаболического синдрома у детей и подростков. В этом обзоре обобщены наши текущие представления о метаболическом синдроме у детей и подростков. This literature review is devoted to the prevalence of metabolic syndrome in children and adolescents. This review summarizes our current understanding of the metabolic syndrome in children and adolescents.

Hypovitaminosis D in type 2 diabetes: relation with features of the metabolic syndrome and glycemic control

2014 ◽  
Vol 40 (3) ◽  
pp. 160-165 ◽  
Author(s):  
Inka Miñambres ◽  
Jose Luis Sánchez-Quesada ◽  
Irene Vinagre ◽  
Joan Sánchez-Hernández ◽  
Eulalia Urgell ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Glycemic Control ◽  
Hypovitaminosis D ◽  
The Metabolic Syndrome
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