scholarly journals Sleep Apnea Is Associated with Cardiovascular Risk Factors among Kidney Transplant Patients

2009 ◽  
Vol 5 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Miklos Zsolt Molnar ◽  
Alpar Sandor Lazar ◽  
Anett Lindner ◽  
Katalin Fornadi ◽  
Maria Eszter Czira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

KIDNEY TRANSPLANT AFTER PERITONEAL DIALYSIS: DOES AN IMPROVEMENT IN CARDIOVASCULAR RISK FACTORS?

2010 ◽  
Vol 90 ◽  
pp. 685
Author(s):  
M. J. Pérez-Sáez ◽  
K. Toledo ◽  
L. González-Burdiel ◽  
M. L. Agüera ◽  
D. Del Castillo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant

The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)

2009 ◽  
Vol 23 (5) ◽  
pp. 616-620 ◽  
Author(s):  
Colin Davenport ◽  
Nadira Hamid ◽  
Eoin P. O'Sullivan ◽  
Padraig Daly ◽  
Ponnusamy Mohan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
The Impact

scholarly journals MON-284 Systematic Screening Reveals Large Number of Undiagnosed and Untreated Cardiovascular Risk Factors in Adults with Prader-Willi Syndrome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Karlijn Pellikaan ◽  
Anna Gerarda Wilhelmina Rosenberg ◽  
Janneke Baan ◽  
Kirsten Davidse ◽  
Aart Jan Van der Lely ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Energy Expenditure ◽  
Cardiovascular Risk Factors ◽  
Health Problems ◽  
Low Energy ◽  
Exercise Intolerance ◽  
Prader Willi Syndrome ◽  
Systematic Screening

Abstract Introduction: Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hypotonia, intellectual disability (ID), pituitary hormone deficiencies and hyperphagia. In PWS, up to 3% of patients die every year. In half of the patients, the cause of death is obesity related and / or of cardiovascular (CV) origin. Obesity is caused by hyperphagia combined with a low energy expenditure. Untreated hormone deficiencies like hypogonadism and hypothyroidism can cause low muscle mass and low basal rest metabolism (BRM) leading to this low energy expenditure. Patients with PWS should exercise one hour daily to compensate for their low BRM. However, hormone deficiencies usually cause fatigue, leading to exercise intolerance. Musculoskeletal and / or behavioral problems can also cause reduced physical activity. The subsequent sedentary lifestyle can induce CV risk factors like hypertension, hypercholesterolemia and diabetes mellitus (DM). Another risk factor often present in PWS is sleep apnea, which can be central (CSA), obstructive (OSA) or both. Both CSA and OSA can lead to pulmonary hypertension and a further increase in obesity. The above mentioned health problems often remain unnoticed and untreated, which is partly due to the behavioral phenotype of PWS (patients seldomly report pain and hardly ever complain about physical problems). However, if left untreated, these risk factors can cause CV complications leading to hospital admission or even death. To reveal yet undiagnosed health problems, we performed a systematic health screening among adults with PWS. Methods: We systematically screened 115 adults with PWS (mean age 31.4 ± 12.1 y, mean BMI 31.8 ± 9,5 kg/m2) for the presence of undiagnosed health problems and cardiovascular risk factors. Based on a medical questionnaire, medical file search, extensive interview, thorough physical examination and biochemical measurements we made an overview of the undiagnosed health problems in adults with PWS. If possible, we performed polygraphy to test for sleep apnea. Results: Undiagnosed health problems (hypertension, DM, hypercholesterolemia, sleep apnea, hypothyroidism and hypogonadism) were present in 50% of the patients. 10% had multiple undiagnosed health problems simultaneously. All males and 94% of females had hypogonadism and 15% had hypothyroidism. Hypertension and / or hypercholesterolemia were present in 20% and DM was present in 16%. One third of patients was not on a diet and 22% exercised less than 30 minutes a day. Sleep apnea was present in 17 of 26 patients tested. Conclusion: We detected a striking number of undiagnosed health problems among adults with PWS which, if left untreated, can pose a serious health threat. Systematic screening is needed to detect these problems in an early phase. This will prevent burdensome and expensive complications and might even reduce mortality in this vulnerable patient population.

Prevalence and Risk Factors of Non-Adherence with Immunosuppressive Medication in Kidney Transplant Patients

2007 ◽  
Vol 7 (1) ◽  
pp. 108-116 ◽  
Author(s):  
K. Denhaerynck ◽  
J. Steiger ◽  
A. Bock ◽  
P. Schäfer-Keller ◽  
S. Köfer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Immunosuppressive Medication ◽  
Kidney Transplant Patients

scholarly journals Incidence of cardiovascular events and associated risk factors in kidney transplant patients: a competing risks survival analysis

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
María Teresa Seoane-Pillado ◽  
Salvador Pita-Fernández ◽  
Francisco Valdés-Cañedo ◽  
Rocio Seijo-Bestilleiro ◽  
Sonia Pértega-Díaz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Analysis ◽  
Kidney Transplant ◽  
Competing Risks ◽  
Cardiovascular Events ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Associated Risk Factors

scholarly journals Waiting List and Kidney Transplant Vascular Risk: An Ongoing Unmet Concern

2019 ◽  
Vol 45 (1) ◽  
pp. 1-27 ◽  
Author(s):  
Domingo Hernández ◽  
Juana Alonso-Titos ◽  
Ana Maria Armas-Padrón ◽  
Veronica Lopez ◽  
Mercedes Cabello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Waiting List ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Pathogenic Mechanisms

Background: Chronic kidney disease (CKD) is an important independent risk factor for adverse cardiovascular events in patients waitlisted for kidney transplantation (KT). Although KT reduces cardiovascular risk, these patients still have a higher all-cause and cardiovascular mortality than the general population. This concerning situation is due to a high burden of traditional and nontraditional risk factors as well as uremia-related factors and transplant-specific factors, leading to 2 differentiated processes under the framework of CKD, atherosclerosis and arteriosclerosis. These can be initiated by insults to the vascular endothelial endothelium, leading to vascular calcification (VC) of the tunica media or the tunica intima, which may coexist. Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC. Summary: This review focuses on the current understanding of atherosclerosis and arteriosclerosis, both in patients on the waiting list as well as in kidney transplant recipients, emphasizing the cardiovascular risk factors in both populations and the inflammation-related pathogenic mechanisms. Key Message: The importance of cardiovascular risk factors and the pathogenic mechanisms related to inflammation in patients waitlisted for KT and kidney transplant recipients.

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