scholarly journals Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as Antidiabetic Potensi Tanaman Mimba (Azadirachta indica A. Juss.) sebagai Antidiabetes

2021 ◽  
pp. 422-430
Author(s):  
Putri Rachma Novitasari ◽  
Baiq Maylinda Gemantari ◽  
Syarifatul Mufidah ◽  
Prita Anggraini Kartika Sari
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Azadirachta Indica ◽  
Review Article ◽  
The Body ◽  
Herbal Extracts ◽  
Alternative Medicines ◽  
Herbal Plants ◽  
Good Potential ◽  
Ancient Times

Many people choose alternative medicines for Diabetes Mellitus (DM) disorders, such as herbal plants to suppress the occurrence of the disease widely. In general, DM occurs when the pancreas doesn't produce enough insulin, or when the body can't effectively use the insulin which it produces. The use of medicinal plants to treat various diseases has shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. In Indonesia, thousands of species of medicinal plants have been studied to address health problems. Among the medicinal plants that have been studied is the Neem plant (Azadirachta indica A. Juss) which has been shown to cure various diseases. This review article describes the potential of the Neem plant as an antidiabetic. The results of this literature review, in the form of Neem herbal extracts, have quite good potential as an antidiabetic because they contain several compounds such as meliacinolin, azachdirichtin, gliserid oil, acetyl oxyturanoe acid and other compounds that can also act as antidiabetic.

scholarly journals Deteksi Dini Faktor Resiko Diabetes Melitus Di Dusun Kalangan Kecamatan Sawangan Kabupaten Magelang

2021 ◽  
Vol 4 (2) ◽  
pp. 103-110
Author(s):  
Febri Ayuningsih ◽  
Rifana Tia Ardana ◽  
Lilik Kurniati ◽  
Arbasita Endarwati ◽  
Imron Wahyu Hidayat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Early Detection ◽  
Keywords Diabetes Mellitus ◽  
The Body ◽  
Healthy Lifestyles ◽  
Keywords Diabetes ◽  
Herbal Plants ◽  
Herbal Medicinal ◽  
Diabetes Melitus

Abstract: One of the subdistricts in Magelang regency which has a problem with the Diabetes Mellitus Disease in the Sawangan District, especially in the area of Sawangan Public Health Center, namely Kalangan, Gondowangi Village. So as the resolve this problem must be done various efforts of early detection in solve the problem of Diabetes Mellitus. One of the solutions to solve this problem is the dissemination as early detection and utilization of Diabetes Mellitus herbal plants. With the socialization and utilization of herbal medicinal plants on Diabetes Mellitus, it is expected that the community can pay attention to healthy lifestyles in the future, reduce the incidence of Diabetes Mellitus in the community and can take advantage of herbal treatments around the house so that people are not dependent on chemical or synthetic treatments that have side effects in the body.     Keywords: diabetes mellitus; early detection; herbal medicinal plants Abstrak: Salah satu Kecamatan yang ada di Kabupaten Magelang yang terdapat masalah Diabetes Mellitus yaitu Kecamatan Sawangan khususnya di wilayah kerja Puskemas Sawangan II yaitu Dusun Kalangan desa Gondowangi. Sehingga untuk mengatasi hal tersebut harus di lakukan berbagai upaya Deteksi Dini dalam mengatasi masalah Diabetes Mellitus. Salah satu dalam mengatasi masalah tersebut di lakukan sosialisasi sebagai bagian deteksi dini Diabetes Mellitus dan pemanfaatan tanaman herbal Diabetes Melitus. Dengan di adakannya sosialisasi dan pemanfaatan tanaman obat keluarga (TOGA) tentang Diabetes Melitus di harapkan mayarakat kedepannya dapat memperhatikan pola hidup sehat, mengurangi kejadian penyakit Diabetes Melitus di masyarakat dan dapat memanfaatkan pengobatan herbal di sekitar rumah agar masyarakat tidak ketergantungan dengan pengobatan kimia atau sintetik yang mempunyai efek samping dalam tubuh. Kata kunci: deteksi dini; diabetes mellitus; tanaman obat keluarga

Indian medicinal plants with antidiabetic potential: An overview

2021 ◽  
pp. 2328-2335
Author(s):  
Monika Sahu ◽  
Vinod Kumar ◽  
Veenu Joshi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
The Body ◽  
Therapeutic Drug ◽  
Major Health ◽  
Synthetic Drugs ◽  
Comprehensive Information ◽  
Chronic Disorders ◽  
The Rich ◽  
Indian Medicinal Plants

Diabetes Mellitus is the most prevalent metabolic disorder which has made it a major health threat worldwide. The available synthetic drugs for the cure of Diabetes mellitus are associated with high cost, various side effects and several limitations. Medicinal plants are the rich depots of the phytochemicals which can be useful for the treatment of chronic disorders. These plants are the better alternative to chemical drugs causing less or no harm to the body. Several plants are traditionally known for their antidiabetic properties but the detail investigation of their active molecules is required in order to be developed as therapeutic drug. Therefore, the present review aims to provide comprehensive information on various Indian medicinal plants, their constituents and mechanism of action for the cure of diabetes mellitus.

scholarly journals ANTI-DIABETIC EFFECT OF ETHANOL EXTRACT OF Copaifera salikounda (HECKEL) AGAINST ALLOXAN-INDUCED DIABETES IN RATS

2021 ◽  
Vol 58 (2) ◽  
Author(s):  
Chinyere Aloke ◽  
Emmanuel Igwe ◽  
Nwogo Obasi ◽  
Pascal Amu ◽  
Egwu Ogbonnia
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
The Body ◽  
Albino Rats ◽  
Dependent Manner

Accumulating evidences have reinforced the use of medicinal plants in the treatment of various ailments as a result of negative side effects associated with conventional drugs. Plant components such as phenols and flavonoids with antioxidant potential have confirmed protective roles against oxidative stress-induced degenerative diseases like diabetes mellitus (DM). The current study was carried out to investigate the effect of seed pod ethanol extract from Copaifera salikounda (SPEECS) in alloxan-induced diabetic rats. SPEECS was obtained by maceration of seed pod powder in absolute ethanol for 72 h, filtered, concentrated and dried in-vacuo. Gas chromatography-mass spectrometry (GC–MS) technique was used to quantitatively elucidate the chemical constituents of SPEECS. Twenty-four male albino rats were randomly allocated into four groups (n=6): normal control, DM control, DM + 200 mg/kg SPEECS and DM + 400 mg/kg SPEECS groups. DM was induced in the Wistar albino rats through intraperitoneal injection of 200 mg/kg body weight of alloxan. After 14 days of treatment, the body weight changes and the fasting blood glucose level were determined in the different groups. Also, serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), total protein (TP), malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were estimated. The GC-MS results confirm nine bioactive compounds with 9-octadecenoic acid (55.75%) being most abundant. SPEECS (200 and 400 mg/kg) administration significantly (P 0.05) caused gain in weight, decreased fasting blood glucose and reversed the elevated liver function enzymes (ALT, AST, ALP) while total TP and ALB were markedly elevated relative to DM control group. Furthermore, SPEECS attenuated the activities of SOD and CAT while the level of MDA was significantly (P 0.05) decreased in dose dependent manner in comparison to the DM control. This study indicated that SPEECS can alleviate hyperglyceamia of DM. Key words: Copaifera salikounda; oxidative stress; medicinal plants; diabetes mellitus; phytochemicals; orthodox ANTIDIABETIČNI UČINEK EKSTRAKTA ETANOLA Copaifera salikounda (HECKEL) NA SLADKORNO BOLEZEN, SPROŽENO Z ALLOXAN-om, PRI PODGANAHIzvleček: Obstaja vedno več dokazov, ki poudarjajo uporabnost zdravilnih rastlin pri zdravljenju različnih bolezni, tudi zaradi različnih negativnih stranskih učinkov, povezanih s konvencionalnimi zdravili. Rastlinske sestavine kot so fenoli in flavonoidi z antioksidativnim potencialom, imajo po nekaterih raziskavah zaščitno vlogo pred degenerativnimi boleznimi, ki jih povzroča oksidativni stres, kot je sladkorna bolezen diabetes mellitus (DM). Študija je bila izvedena z namenom raziskovanja učinka etanolnega semenskega ekstrakta iz rastline Copaifera salikounda (SPEECS) pri podganah s sladkorno boleznijo, ki jo je povzročil alloxan. SPEECS je bil pridobljen z maceracijo praška semen v prahu v absolutnem etanolu 72 ur ter nadaljnjo filtracijo, koncentracijo in sušenjem v vakuumu. Za kvantitativno ugotavljanje kemijskih sestavin SPEECS je bila uporabljena tehnika plinske kromatografije in masne spektrometrije (GC-MS). Štiriindvajset samcev podgan Wistar je bilo naključno razporejenih v štiri skupine (n=6): normalna kontrola, kontrola DM, DM + 200 mg/kg SPEECS in DM + 400 mg/kg SPEECS. DM je bil pri podganah sprožen z intraperitonealno injekcijo 200 mg/kg telesne mase alloxana. Po 14 dneh zdravljenja so bile pri različnih skupinah določene spremembe telesne teže in nivo glukoze v krvi (na tešče). Poleg tega so avtorji raziskave izmerili še nekatere serumske biokemične parametre kot so ravni alaninske aminotransferaze (ALT), aspartatne aminotransferaze (AST), alkalne fosfataze (ALP), albumina (ALB), skupnih proteinov (TP), malondialdehida (MDA), superoksiddismutaze (SOD) in katalaze (CAT). Rezultati GC-MS so v izvlečku SPEECS pokazali devet bioaktivnih spojin, v katerih je največ 9-oktadecenojske kisline (55,75%). SPEECS (200 in 400 mg/kg) je povzročil znatno (P 0,05) povečanje telesne mase, znižanje glukoze v krvi na tešče in znižal raven encimov pokazateljev jetrne funkcije (ALT, AST, ALP), medtem ko je bila raven TP in ALB pri podganah, ki so prejemale SPEECS izrazito povišana v primerjavi z DM kontrolno skupino. Zdravljenje s  SPEECS je tudi oslabilo aktivnosti SOD in CAT, medtem ko se je raven MDA znatno zmanjšala (P 0,05) v primerjavi s kontrolno skupino DM. Ta študija je pokazala, da lahko SPEECS ublaži hiperglikemijo pri sladkorni bolezni pri podganah.Ključne besede: Copaifera salikounda; oksidativni stres; zdravilne rastline; sladkorna bolezen; fitokemikalije; ortodoksni

scholarly journals Plants as Immunity Enhancers: A Review

2021 ◽  
Vol 23 (08) ◽  
pp. 92-106
Author(s):  
◽  
Payal Mittal ◽  
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Research Area ◽  
Present Review ◽  
Active Principle ◽  
Active Constituents ◽  
Herbal Plants ◽  
Ancient Times

It is an evident from ancient times that herbs and medicinal plants have the potential to cure a variety of diseases. Some plants boosts our immunity and make our immune system more powerful to fight againt various diseases. The medicinal effects shown by the plants are due to active principle compound present in them and they work in the same manner as the conventioal drugs. Indian herbs and medicinal plants show miraculous effects against wide variety of diseases and disorders in humansand can be better called as “elixers of life”. Currently, the interest is increasing with high pace in the use of active constituents of medicinal plants as modulator or enhancer of complex immune system. From the literature of various studies carried out in the research area , it is culminated that many of the chemicals in the form of alkaloids, flavanoids, anti-oxidants, tannins, terpenes, and glycoside products are responsible to empower the immunmodulator effect. Keeping in mind , the appreciating potential of active constituents of medicinal plants and their derived drugs, present review is an attemptto globally popularize the herbal plants with Immunomodulator Activity.

scholarly journals A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES

2018 ◽  
Vol 11 (2) ◽  
pp. 48 ◽  
Author(s):  
Deepa Rajendiran ◽  
Subbulakshmi Packirisamy ◽  
Krishnamoorthy Gunasekaran
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Medicinal Plants ◽  
Major Part ◽  
Review Article ◽  
Hypoglycemic Activity ◽  
Antioxidants Activity ◽  
Treatment Of Diabetes

 Diabetes mellitus is a chronic metabolic disease. Oxidative stress plays a major part in the pathogenesis of diabetes. Supplementation with antioxidants and the medicinal plants which possess antioxidants activity have been reported their hypoglycemic activity. The antioxidants are used to treat and reduce the complication of diabetes mellitus. The diet supplementations of antioxidants vitamins are beneficial in the treatment of diabetes. This review article was summarizing the role of antioxidants in diabetes mellitus.

scholarly journals Mare's milk as a prospective functional product

2018 ◽  
Vol 8 (11) ◽  
pp. 548 ◽  
Author(s):  
Almagul Kushugulova ◽  
Samat Kozhakhmetov ◽  
Rashida Sattybayeva ◽  
Ayaulym Nurgozhina ◽  
Arailym Ziyat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Inflammatory Diseases ◽  
The Body ◽  
Functional Product ◽  
Ancient Times ◽  
The Relationship

Background: Food has a significant effect on the health of the body, the relationship between diet and health actualizes the importance of expanding the research of functional products. Kazakhstan has a huge potential for functional products, such as saumal, or mare's milk. Since ancient times saumal has been used as an antidote, since it has the ability to excrete toxins. Today it is used for pulmonary tuberculosis, anemia, rickets, diabetes mellitus, obesity, nerve diseases, inflammatory diseases of the stomach and intestines. Saumal is called a longevity drink.

scholarly journals Protective Role of Herbal Drugs in Diabetic Neuropathy: An Updated Review

2018 ◽  
Vol 6 (1) ◽  
pp. 21-30
Author(s):  
Eshita Sharma ◽  
Tapan Behl ◽  
Monika Sachdeva ◽  
Rashita Makkar ◽  
Sandeep Arora
Keyword(s):  
Health Care ◽  
Neuropathic Pain ◽  
Medicinal Plants ◽  
Diabetic Neuropathy ◽  
Review Paper ◽  
Protective Role ◽  
Herbal Drugs ◽  
Herbal Plants ◽  
Ancient Times

Medicinal plants play a beneficial role in health care and are commonly used in preventing and testing diseases and specific ailments. The advantage associated with herbals plants are numerous and cannot be ignored as they have less adherence issues and are accepted widely by the population due to greater belief in Ayurveda since ancient times. Neuropathic pain has immersed as a serious threat to patient that occurs by damaging the blood vessels leading to morbidity and mortality. The present review paper aims in providing an account of various herbal plants that could be employed in treatment of neuropathic pain.

scholarly journals Inhibition of α-glucosidase Activity Seed Extract from Mahogany (Swietenia macrophylla King.)

2019 ◽  
Vol 6 (1) ◽  
pp. 35-44
Author(s):  
Waras Nurcholis ◽  
Rini Muthoharoh ◽  
Antonius Padua Ratu
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Aqueous Extract ◽  
Ethanol Extract ◽  
The Body ◽  
Phytochemical Screening ◽  
Swietenia Macrophylla ◽  
Glucosidase Activity ◽  
Traditional Medicinal Plants ◽  
Chronic Disorder

Diabetes mellitus is a chronic disorder that affects the metabolism of blood glucose inside the body. One of the alternative treatments is by using traditional medicinal plants, which have hypoglycemia effects. A mahogany seed is one of the traditional medicinal plants that has been proven to treat diabetes and has been used for generations.  In the aqueous extract, ethanol 96 %, ethyl acetate, and hexane from mahogany seeds (Swietenia macrophylla King.) the inhibition of α-glucosidase activity are checked by measuring p-nitrophenol from p-nitrophenyl-α-D-glucopyranose (pNPG) on 400 nm.  The percentage value of the inhibition for α-glucosidase ranged from 6,36-56,77 %, with 96 % ethanol extract that has the highest value and the hexane extract with the lowest value.  Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and triterpenoids, which could be responsible for the bioactivities shown by the 96 % ethanol extract and aqueous extract of S. macrophylla.  Keywords :  α-glucosidase activity, diabetes mellitus, mahogany seeds (Swietenia macrophylla King.), phytochemical screening.

scholarly journals Mechanisms of Action of Flavonoids in the Management of Diabetes mellitus

2021 ◽  
Vol 11 (5-S) ◽  
pp. 194-202
Author(s):  
S Chandra Mohan ◽  
Namrata Jain ◽  
S. Sumathi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Mechanisms Of Action ◽  
The Body ◽  
Antidiabetic Activity ◽  
Cost Of Treatment ◽  
Keywords Diabetes ◽  
Microvascular And Macrovascular Complications ◽  
Chronic Use

Management of diabetes mellitus is a challenge for clinicians. Uncontrolled hyperglycemia increases the risk of microvascular and macrovascular complications, damaging the body systems.  Although a number of antidiabetic drugs are available for therapeutic intervention, toxicity, loss of efficacy in chronic use and high cost of treatment have necessitated the search for new molecules to manage diabetes. Safety and cost are the main prerequisite for the new antidiabetic molecules. Medicinal plants and their purified phytochemicals have shown promising antidiabetic potential in the past few years. The flavonoids can be widely classified into different categories like anthocyanins, catechins, flavanols, flavones, flavanones etc. Some flavonoids have hypoglycemic properties. They may improve al-tered glucose and oxidative metabolisms of diabetic states. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes mellitus (T2DM). Some of the important phytoconstituents from the classes of flavonoid have been discussed here. The current review summarizes the  antidiabetic activity of flavonoids, the mechanism-based action of flavonoids that target the various metabolic pathways in humans. Keywords: Diabetes mellitus, Flavonoids, Medicinal plants, mechanisms of action, T2DM

Medicines to Prevent the Effects of Age

2017 ◽  
Vol 14 (4) ◽  
pp. 39-51
Author(s):  
Jose George
Keyword(s):  
Medicinal Plants ◽  
The Body ◽  
Asparagus Racemosus ◽  
Human Beings ◽  
Herbal Plants ◽  
Almost All

The Indian system of medicine classifies panacea (herbal plants) into different classes according to their supposed action on different organs of the body or on particular symptoms of diseases. Charaka had divided medicines into fifty classes and had given the names of some medicinal plants which are useful to prevent the effects of age. Almost all human beings are anxious about their ageing and the problems allied to it and would be glad to retain youthfulness. This article introduces certain herbal plants and their use as a tonic or as a medicine for various diseases. They can be used as a panacea or in combination with other drugs. I. Asparagus racemosus (Willd)

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