scholarly journals The affected factors of loss to follow up (LFU) among HIV patients with antiretroviral therapy (ART) in Dr. Sardjito General Hospital, Yogyakarta, Indonesia

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Sri Purwaningsih ◽  
Yanri Wijayanti Subronto ◽  
Erna Kristin
Keyword(s):  
Antiretroviral Therapy ◽  
Functional Status ◽  
General Hospital ◽  
Medical Records ◽  
Hiv Patients ◽  
Early Therapy ◽  
Loss To Follow Up ◽  
Medical Status ◽  
Significant Factors

HIV infection is a global issue which is related to the increasing cases of HIV and AIDS in various countries including in Indonesia. Antiretroviral therapy (ART) that addressed for reducing the virus proliferation is not always followed by good medication adherence among patients. The ART loss to follow up (LFU) is a common problem in Indonesia. However, information concerning the affected factors of LFU among HIV patients with ART is limited. This study aimed to investigate the affected factors of LFU among HIV patients in the early two years of ART. A retrospective cohort study was conducted in Dr. Sardjito General Hospital, Yogyakarta among 369 medical records of HIV patients that met the inclusion and exclusion criteria. The inclusion criteria were HIV patients who started ART in January 2008 to December 2012, aged > 17 years with a complete medical records. The data of sociodemography and medical status patients were obtained from medical record, ART, and pharmacy register of the patients. Patient characteristics observed in this study included demographic factors such as age, sex, residence, education level, risk factors, and also medical status factors such as clinical stage, tuberculosis (TB) co-infection, functional status, and CD4 cell counts. The data were analyzed using Kaplan Meier and Cox Proportional Hazard. The results showed that patients with TB co-infection in early therapy and working functional status were significant factors of LFU (p<0.05). Patients without TB co-infection were half as much protected from LFU compared to patients with TB infection (HR=0.50; 96%CI: 0.34-0.75). It can be concluded that TB coinfection in early therapy and working fuctional status are the significant factors that influenced the LFU incidents in the two years of early therapy.

scholarly journals Functional Status and Incidence of Loss to Follow-up after Antiretroviral Therapy Initiation

2021 ◽  
Author(s):  
Rosita Dewi Ambarwati ◽  
Hartati Eko Wardani ◽  
Tika Dwi Tama
Keyword(s):  
Antiretroviral Therapy ◽  
Functional Status ◽  
General Hospital ◽  
Rank Test ◽  
P Value ◽  
Hiv Patients ◽  
Loss To Follow Up ◽  
Cox Proportional Hazard ◽  
The Right

Taking medication for lifetime puts Human Immunodeficiency Virus (HIV)-infected patients in challenging situations. The loss to follow-up (LTFU) is a major problem arising from their non-compliance. Information about functional status as a predictor of LTFU is limited. Therefore, this study was aimed to identify the association between the functional status and the incidence of LTFU among HIV patients at Saiful Anwar General Hospital, Indonesia. A retrospective cohort study was conducted in the tropical diseases and infections division of the Saiful Anwar General Hospital by observing 148 HIV patients who were diagnosed in 2015. Data were collected based on existing data in medical records. The log-rank test was used to compare the time of LTFU between groups. Cox proportional hazard was used to determine the effect of functional status after being controlled by other variables. This study found that 65.9% of HIV patients were able to retain on antiretroviral therapy for 39 months. Functional status had a significant association with the time LTFU occurred. Ambulatory patients had a higher risk of experiencing LTFU than working functional status (AHR = 2.289; 95% CI 1.106–4.738; p-value = 0.026). Identifying the patient’s characteristic that has a higher risk of LTFU helps to determine the right strategy to ensure treatment adherence. Keywords: antiretroviral therapy (ART), functional status, HIV, loss to follow-up (LTFU), Indonesia

scholarly journals Moderate incidence of lost follow-up and risk factors among adult HIV patients on second-line ART regimens in Amhara region hospitals, Ethiopia

2019 ◽  
Vol 9 (1-s) ◽  
pp. 52-59
Author(s):  
Ahmed Mohammed ◽  
Saed Abdi ◽  
S Palani ◽  
Nisha Mary Joseph
Keyword(s):  
Risk Factors ◽  
Antiretroviral Therapy ◽  
Functional Status ◽  
Cumulative Incidence ◽  
Categorical Variables ◽  
Second Line ◽  
Amhara Region ◽  
Hiv Patients ◽  
Loss To Follow Up

Background and Objectives: Loss to follow-up is a common problem of most patients on antiretroviral therapy in Ethiopia. Second-line antiretroviral therapy is the drug that would be used when the first-line therapy fails.  Thus this study intends to determine the incidence and risk factors of time to losses to follow up among  Human  Immunodeficiency  Virus (HIV) patients on second line regimens of  Antiretroviral Therapy(ART) in Amhara region Hospitals, Ethiopia. Methods: Institutional based retrospective cohort study was conducted in the Amhara region hospitals from February to March 2016. A total of 1246 patient from eight hospitals in Amhara region were selected using simple random sampling method and data were extracted from patient charts.  The log rank test was used to assess presence of significant difference in time to losses to follow among levels of categorical variables. Both bi-variiable and multivariable Cox proportional hazards models were used to identify factors that affect the time to losses to follow up.    Results: The cumulative incidence of loss to follow up was 5.41% over the entire (eight) years of follow-up. The cumulative incidence rates of death and transfer out were 10.99%,10.02 %, respectively. In multivariable Cox regression analysis, ambulatory functional status (AHR=0.1967, 95% CI: 0.049- 0 .794), male gender (AHR=2.135, 95% CI: 1.053- 4.330),  adherence to ART (AHR=0.442, 95% CI: 0.198- 0.989) were significant predictors of time to losses to follow up. The use of 2a, 2e and 2g types of second line regimen reduced the risk of  loss to follow up. Interpretations and Conclusions: The incidence of loss to follow up in Amhara region hospitals was low. Loss to folow up was negatively  associated with female gender, ambulatory  baseline functional status, adherence, & types of second line regimen types. Further research on the effect of  types of drug is recommended by acertaining whether the reduction in loss to follow up  for patients who took drug types of 2a, 2e, and 2g is associaed with improved or worsened health outcomes by trafcking lost patients closely.  

scholarly journals High rates of loss to follow-up during the first year of pre-antiretroviral therapy for HIV patients at sites providing pre-ART care in Nigeria, 2004–2012

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183823 ◽  
Author(s):  
Simon G. Agolory ◽  
Andrew F. Auld ◽  
Solomon Odafe ◽  
Ray W. Shiraishi ◽  
E. Kainne Dokubo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
First Year ◽  
Hiv Patients ◽  
Loss To Follow Up

scholarly journals Predictors of Loss to Follow-Up among HIV-Infected Adults after Initiation of the First-Line Antiretroviral Therapy at Arba Minch General Hospital, Southern Ethiopia: A 5-Year Retrospective Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mathewos Alemu Gebremichael ◽  
Mekdes Kondale Gurara ◽  
Haymanot Nigussie Weldehawaryat ◽  
Melkamu Merid Mengesha ◽  
Dessalegn Ajema Berbada
Keyword(s):  
Cohort Study ◽  
Antiretroviral Therapy ◽  
General Hospital ◽  
Retrospective Cohort Study ◽  
Survival Probability ◽  
Retrospective Cohort ◽  
First Line ◽  
Loss To Follow Up ◽  
Cumulative Survival

Background. Loss to follow-up (LTFU) from antiretroviral therapy (ART) reduces treatment benefits and leads to treatment failure. Hence, this study was aimed at determining the incidence of loss to follow-up and predictors among HIV-infected adults who began first-line antiretroviral therapy at Arba Minch General Hospital. Methods. We carried out an institutional-based retrospective cohort study, and data were collected from the charts of 508 patients who were selected using a simple random sampling technique. All the data management and statistical analyses were conducted using STATA version 14. Cumulative survival probability was estimated and presented in the life table, and the Kaplan-Meir survival curves were compared using the log-rank test. The Cox proportional hazard model was used to identify the independent predictors. Results. We followed 508 patients for 871.9 person-years. A total of 46 (9.1%) experienced loss to follow-up, yielding an overall incidence rate of 5.3 (95% CI: 3.9-7.1) per 100 person-years. The cumulative survival probability was 90%, 88%, 86%, and 86% at the end of one, two, three, and four years, respectively. The predictors identified were age less than 35 years (adjusted hazard ratio ( aHR = 1.96 ; 95% CI: 1.92-4.00)), rural residence ( aHR = 1.98 ; 95% CI: 1.02-3.83), baseline body weight greater than 60 kilograms ( aHR = 2.19 ; 95% CI: 1.11-4.37), a fair level of adherence ( aHR = 11.5 ; 95% CI: 2.10-61.10), and a poor level of adherence ( aHR = 12.03 ; 95% CI: 5.4-26.7). Conclusions. In this study, the incidence rate of loss to follow-up was low. Younger adults below the age of 35 years, living in rural areas, with a baseline weight greater than 60 kilograms, which had a fair and poor adherence level were more likely to be lost from treatment. Therefore, health professionals working in ART clinics and potential stakeholders in HIV/AIDS care and treatment should consider adult patients with these characteristics to prevent LTFU.

Patient Loss to Follow-Up Before Antiretroviral Therapy Initiation in Rural Mozambique

2014 ◽  
Vol 19 (4) ◽  
pp. 666-678 ◽  
Author(s):  
Monica da Silva ◽  
Meridith Blevins ◽  
C. William Wester ◽  
José Manjolo ◽  
Eurico José ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Loss To Follow Up ◽  
Therapy Initiation
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