scholarly journals Estimating Pulmonary Function, Interleukin-6 (IL-6), And Superoxide Dismutase-3 (EC-SOD3) Levels in Patients with Chronic Bronchial Asthma on Curcumin Adjuvant Therapy

2021 ◽  
Author(s):  
Sura abbas Khdair ◽  
Manal khalid Abdulridha
Keyword(s):  
Pulmonary Function ◽  
Bronchial Asthma ◽  
Interleukin 6 ◽  
Study Groups ◽  
Super Oxide Dismutase ◽  
Function Test ◽  
The Mean ◽  
Group 2 ◽  
To Receive ◽  
Group 1

This study was designed to evaluate the effectiveness of curcumin supplement as antioxidant and anti-inflammatory in patients with chronic bronchial asthma. Forty patients diagnosed with chronic bronchial asthma were enrolled in this study and allocated into group (1) patients   assigned to receive conventional therapy of asthma, and group (2) patient assigned to receive conventional therapy of asthma combined with 750 mg curcumin supplement twice daily for two months. Pulmonary function test, asthma control test, serum interleukin-6 and serum extracellular super oxide dismutase 3 were measured before and after two months in both study groups. After two months, the mean values of pulmonary function test (spirometry) and asthma control score showed significant increase compared to pre-treatment values in group 2 patients (P<0.01). Moreover, there was marked decrease in the level of interleukin-6 in group 2 patients after two months (p< 0.05) compared to the increased in group 1 patients. The mean level of super oxide dismutase 3 didn’t show any increase in both study groups after treatment. Curcumin supplement produced improvement in pulmonary function of patients with chronic bronchial asthma along with the reduction in inflammatory status. No change in endogenous oxidative status after curcumin supplementation.

scholarly journals The use of an antagonist 5-HT2a/c for depression and motor function in Parkinson' disease

2009 ◽  
Vol 67 (2b) ◽  
pp. 407-412 ◽  
Author(s):  
Antonio Luiz dos Santos Werneck ◽  
Ana Lucia Rosso ◽  
Maurice Borges Vincent
Keyword(s):  
Parkinson Disease ◽  
Motor Function ◽  
Rating Scale ◽  
Statistical Significance ◽  
Psychotic Symptoms ◽  
Initial Moment ◽  
The Mean ◽  
Group 2 ◽  
To Receive ◽  
Group 1

OBJECTIVE: To test the ability of a 5HT2a/c (trazodone) antagonist, to improve depression and motor function in Parkinson' disease (PD). METHOD: Twenty PD patients with and without depression were randomly assigned to receive trazodone (group 1) or not (group 2). They were evaluated through UPDRS and Hamilton Depression Rating Scale (HAM-D). RESULTS: For the UPDRS the mean score of group 2 was 33.1 ± 19.7 and 37.1 ± 18.0 at the end. For the group 1, the corresponding scores were 31.4 ± 11.3 and 25.9 ± 13.7. The variations in the Mann-Whitney test were 0.734 at the initial moment and 0.208 at the final moment. The variation in the comparison of the initial moment with the final moment was 0.005 providing statistical significance. For the HAM-D, the mean score went up 4 points in group 2, contrary to a 5.5 points decrease in group 1. CONCLUSION: Data analysis shows that this agent significantly improves depression, but the motor function improved only in the depressed patients. Because of the known anti-dopaminergic property of the 5-HT2c receptors, a possible approach for depression in PD could be the use of 5-HT2c antagonists, similarly to the use of atypical neuroleptics in case of psychotic symptoms.

scholarly journals The effect of pharmacological correction with vitamin D on the cytokine response in children with atopic bronchial asthma

2019 ◽  
Vol 100 (1) ◽  
pp. 135-139
Author(s):  
L I Allakhverdiyeva ◽  
N G Sultanova ◽  
A O Dzhafarova
Keyword(s):  
Vitamin D ◽  
Bronchial Asthma ◽  
Interleukin 2 ◽  
Interleukin 13 ◽  
Atopic Bronchial Asthma ◽  
The Mean ◽  
Pharmacological Correction ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Group 1

Aim. To study the state of the cytokine response in children with atopic bronchial asthma during pharmacological correction with vitamin D. Methods. 63 children aged 3-17 years with atopic bronchial asthma of varying severity were examined. As a control group, 10 practically healthy children of the same age who had no history of allergic manifestations and no hereditary complications, were examined. The patients were divided into two groups matched by age: group 1 included 33 patients with mild (n=20) and moderate (n=13) bronchial asthma who received only basic anti-inflammatory therapy according to the severity of asthma; group 2 included 30 children with mild (n=18) and moderate (n=12) bronchial asthma who received basic anti-inflammatory therapy with vitamin D containing Tridrop [3 drops (1500 IU) per day for 1 month]. Patients were assessed for interleukin-2, -13 and -17 in the blood serum using a solid-phase enzyme-linked immunosorbent assay before and after treatment. Results. The results obtained made it possible to clarify the changes in the cytokine spectrum in patients with atopic bronchial asthma in the course of the disease and the effect of pharmacological correction with vitamin D on it. The mean level of interleukin-2 in group 1 remained practically unchanged, the value of this cytokine was 2.77±1.51 pg/ml (p >0.05). In group 2, the mean interleukin-2 level increased to 5.07±1.02 pg/ml (p <0.01). The mean level of interleukin-13 in group 1 patients increased but not significantly, but in group 2 a decrease of interleukin-13 to 11.3±3.8 pg/ml (p <0.05) was registered. Interleukin-17 decreased by 2.6 times in group 2 (4.8±1.6 pg/ml, p <0.01). In group 1 there was no significant change in the level of interleukin-17, in all children it remained elevated (p >0.05). Conclusion. Pharmacological correction with vitamin D on the background of basic anti-inflammatory therapy promotes the positive dynamics of the level of cytokines during the treatment of atopic bronchial asthma, which is related to the ability of vitamin D to regulate the function of Th2 and, as a result, to reduce the synthesis of interleukin-13 and -17, which participate in the pathogenesis of allergies and play an important protective role in bronchial asthma.

scholarly journals Immersion in Water During Active Labor Decreases Postpartum Hematocrit Fall Following Vaginal Delivery

2018 ◽  
pp. 1
Author(s):  
Gul Nihal Buyuk ◽  
Serkan Kahyaoglu ◽  
Ezgi Turgut ◽  
Omer Hamid Yumuşak ◽  
Caner Kose ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Postpartum Hemorrhage ◽  
Study Groups ◽  
Normal Vaginal Delivery ◽  
Control Group ◽  
The Mean ◽  
Group 2 ◽  
Water Birth ◽  
Control Group Group ◽  
Group 1

<p><strong>OBJECTIVE:</strong> The objective of the study was to investigate the effect of immersion in water strategy during labor on postpartum bleeding by calculating the postpartum reduction rates of the hematocrit values of the patients.</p><p><strong>STUDY DESIGN:</strong> The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (group 1) and the control group (group 2) of 84 women undergoing normal vaginal delivery. Patients who have received additional medical and surgical interventions for alleviation of postpartum hemorrhage, patients who have undergone an episiotomy and/or perineal trauma were not included in the study. All data were taken from patients who have delivered with spontaneous vaginal delivery. Postpartum hematocrit fall rates of the groups have been compared and the effect of immersion in water on postpartum hemorrhage has been evaluated.</p><p><strong>RESULTS:</strong> The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (Group 1) and the control group (Group 2) of 84 women undergoing vaginal delivery at the hospital. The women in the two groups were matched with respect to age, parity, birth weight and gestational age. The mean age of the women was 29.8±4.8 and 30.5±4.9 respectively. The mean hematocrit difference in the first group was 2.08 ± 1.88 and in the second group was 3.81 ± 1.55. The mean percentage of hematocrit reduction in the first group was 5.71% and in the second group 10.23%.</p><p><strong>CONCLUSION:</strong> Our data showed that mean hematocrit level decreases among women following vaginal delivery more than women who give birth vaginally within immersion in water during labor. The percentage of hematocrit reduction in the water birth group was lower than in the control group. Water birth seems to facilitate uterine contractions more efficiently following vaginal delivery.</p>

scholarly journals Laparoscopic versus open varicocelectomy comparative study for early post-operative complications among patients in Basrah, Iraq

2018 ◽  
Vol 5 (4) ◽  
pp. 1176
Author(s):  
Alaa H. Ali ◽  
Hussain A. Alhilfy ◽  
Mahmood S. Alharoon
Keyword(s):  
Wound Infection ◽  
Harmful Effect ◽  
Study Groups ◽  
Operative Complications ◽  
Scrotal Edema ◽  
The Mean ◽  
Operation Group ◽  
Group 2 ◽  
Group 1 ◽  
Post Operative Complications

Background: Varicocele is considered a major cause of male infertility. The target of varicocele surgery is to remove the progressive harmful effect of the varicocele on the testes. The aim of this study was to evaluate post-operative complications of laparoscopic versus open varicocelectomy.Methods: This prospective study involved 60 patients who presented to Al-Basra general hospital, or Al-Sader teaching hospital complaining of pain, infertility, or both and diagnosed to have testicular varicocele. Patients were split into 2 groups relative to the type of operation. Group 1 comprised 25 patients who had undergone laparoscopic varicelectomy, and group 2 comprised 35 patients who had undergone open subinguinal varicelectomy.Results: The mean age of the patients was 25.3±2.1 years in group 1 and 24.4±3.4 years in group 2. Wound infection, hematoma formation, and scrotal edema occurred in the study groups but were higher for open technique.Conclusions: Author concluded in this study that it seems to be laparoscopic varicocelectomy technique has less early post-operative complication in term of wound infection, hematoma and edema.

1273Efficacy and safety of prehabilitation before coronary artery bypass grafting

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y Argunova ◽  
A Korotkevich ◽  
E Belik ◽  
S Pomeshkina ◽  
O Barbarash
Keyword(s):  
Coronary Artery ◽  
Myocardial Perfusion ◽  
High Intensity ◽  
Troponin I ◽  
Artery Bypass ◽  
Study Groups ◽  
Preoperative Management ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Abstract Purpose To evaluate the effectiveness and safety of high intensity prehabilitation included in the routine preoperative management of patients with coronary artery disease (CAD) for elective on-pump coronary artery bypass grafting (CABG). Methods 38 male patients with stable CAD referred to on-pump CABG who either underwent prehabilitation or not were assigned into two study groups. Group 1 patients (n=20, the mean age 61.5 years [55; 64] underwent high intensity treadmill exercises. Group 2 patients (n=18, the mean age 62.0 years [56; 65]) underwent routine preoperative management without prehabilitation. Treadmill exercises in Group 1 patients were performed under hemodynamic control and ECG monitoring. The training power of a workout was calculated based on cardiopulmonary exercise test (CPET) performed before preoperative exercises, and was estimated as 80% of the maximal power obtained during the exercise test. Adenosine loading single-photon emission computed tomography (SPECT) was used to measure the parameters of myocardial perfusion before preoperative exercises and on days 5–7 after CABG in both study groups. Biochemical markers of myocardial damage (troponin I, NT-proBNP) were measured before the training session, after it and then in the postoperative period to assess the safety of the prehabilitation program. In-hospital postoperative complications were recorded and analyzed. Results Both study groups were comparable in the main clinical and demographic parameters, intraoperative clinical parameters as well as in preoperative CPET and SPECT results. There were no cases of complications during prehabilitation. The analysis of myocardial perfusion parameters demonstrated that patients who had undergone prehabilitation had significantly higher accumulation of radiopharmaceuticals than those in the control group in basal segments (74.9±3.98% vs. 70.3±7.40% p=0.04), middle (86.7±5.24% vs. 79.6±10.43%, p=0.03) and apical (85.8±5.03% vs. 79.0±8,67%, p=0.02) myocardium. The stress-induced ischemia (SDS) was less pronounced in Group 1 compared to Group 2 (0 scores and 0.9±0.53 scores, respectively, p=0.04). Myocardial perfusion defect significantly decreased during the infusion of adenosine (SSS) (p=0.013), as well as the SDS index (p=0.018) in the prehabilitation group after CABG compared with the baseline. Both groups had similar serum troponin I levels within the normal range before and after CABG. NT-pro BNP levels significantly increased in the postoperative period in patients who did not undergo prehabilitation (p=0.003). Patients who underwent prehabilitation had a significantly lower incidence of the in-hospital postoperative complications compared to patients without exercise trainings (p=0.002). Conclusion The inclusion of high intensity preoperative exercises in the routine preoperative management of patients referred to elective CABG is safe and effective method of cardioprotection improving surgical outcomes.

Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas

1976 ◽  
Vol 45 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Bryce Weir ◽  
Pierre Band ◽  
Raul Urtasun ◽  
Gilles Blain ◽  
Don McLean ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Content Type ◽  
Significant Difference ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
To Receive ◽  
Mean Time ◽  
Grade Iii ◽  
Group 1

✓ Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) received radiation therapy totaling 4000 to 4500 rads in 4 to 5 weeks. Group 2 (13 patients) received 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) 130 mg/sq m orally every 6 weeks. Group 3 (13 patients) received radiation therapy plus CCNU as for Groups 1 and 2. When the disease progressed, patients in Groups 1 and 2 were crossed over to receive CCNU and irradiation respectively. The median survival time in these groups was 188, 259, and 252 days, and the mean survival 263, 262, and 329 days. The median time from diagnosis to crossover (Groups 1 and 2) or to progression (Group 3) was 163, 99, and 220 days, and the mean time was 172, 108, and 231 days. There was no statistically significant difference between the means or medians in any of these situations.

scholarly journals Effect of rituximab on the manifestations of activity and pulmonary function in patients with systemic sclerosis: one-year follow-up evaluation

2019 ◽  
Vol 57 (3) ◽  
pp. 265-273 ◽  
Author(s):  
L. P. Ananyeva ◽  
O. A. Koneva ◽  
O. V. Desinova ◽  
L. A. Garzanova ◽  
S. I. Glukhova ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Pulmonary Function ◽  
Safety Profile ◽  
Left Ventricular Ejection ◽  
The Mean ◽  
Group 2 ◽  
One Year ◽  
Tract Infections ◽  
Group 1

The choice of drugs for the treatment of interstitial lung disease (ILD) associated with systemic sclerosis (SS) is currently very limited. Data from a number of studies show that rituximab (RTM) can improve lung function and reduce the severity of skin fibrosis in patients with SS.Objective: to evaluate the efficiency of RTM in a cohort of patients with SS-associated ILD after one-year follow-up. The indications for prescribing RTM were: 1) the inefficiency of standard therapy with glucocorticoids and immunosuppressants (ISs) or the impossibility of their use; 2) the early stage (first 3 years of the disease) with signs of poor prognosis, such as diffuse form, high skin scores (>14), male gender, rapid progression with a significant initial decline in forced vital capacity (FVC) and/or diffusion lung capacity (DLC), and a high anti-Scl-70 antibody positivity.Subjects and methods. The investigators selected a group of patients who had at least two assessment points at a 12-to-18 month interval (the mean follow-up period of 13±2 months) and took at least 1 g of RTM during this period. The investigation included 71 patients with a valid diagnosis of SS. Multi-slice spiral computed tomography (MSCT) revealed ILD in 90% of patients. The disease duration was 5.6±4.4 years. The presence of anti-Scl-70 antibodies was detected in 73% of patients. The mean cumulative dose of RTM was 1.43±0.6 g; 48 patients in Group 1 received ≤2 g of RTM (the mean dose, 1.1±0.1 g) and 23 patients in Group 2 took ≥2 g of RTM (mean dose, 2±0.6 g). Before starting treatment with RTM, all the patients received concomitant therapy with prednisone and 45% - with immunosuppressants.Results and discussion. The results assessed by a physician showed that good and moderate effects of the therapy were observed in 52 (73.2%) and 16 (22.6%) patients, respectively; no effect was seen in 3 (4.2%) patients. Overall, 95.8% of patients reported various degrees of improvement. There were significant changes as reductions in the disease activity index, skin scores, C-reactive protein and IgG levels, the number of patients with a high antinuclear antibody level, and the mean dose of prednisolone as well as increases in an oral aperture size, left ventricular ejection fraction, and 6-minute walk test scores. There were no changes in pulmonary artery systolic pressure and the HAQ DI. FVC increased from 77.35±19.9 to 82.6±20.7% (p=0.001). A minimal clinically significant increase in FVC ≥5% was noted in 41 (57.7%) people. The overall improvement in FVC (ΔFVC) reached 5.24%, while the changes were more significant in Group 2 (ΔFVC 8.98%) than in Group 1 (ΔFVC 3.75%; p=0.01). DLC remained stable, but there were significant group differences: ΔDLC was 3.75% in Group 2 and, conversely, decreased in Group 1 (1.6%; p=0005). The safety profile of the therapy was regarded as good and quite comparable with both the safety profile of ISs and the use of RTM in other trials. Infectious complications were recorded to be most common in 11 (15%) people. Of these, upper respiratory tract infections developed in 7 patients; plantar phlegmon occurred in one case; urinary tract infection and herpes zoster were detected in two and one cases, respectively.The results of this study confirm data from other studies that have demonstrated that RTM exerts a positive effect on SS-associated ILD. We were the first to show the association of positive changes in the measures of pulmonary function tests with the dose of RTM.

scholarly journals Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome

2020 ◽  
Vol 3 (4) ◽  
pp. 162-169
Author(s):  
Ahmed Elmelhat ◽  
Essam Elbourai ◽  
Hany Dewedar ◽  
Taghrid Elgergawi ◽  
Maryam Alkhanbouli ◽  
...  
Keyword(s):  
Therapeutic Dose ◽  
Inflammatory Markers ◽  
Study Groups ◽  
Prophylactic Dose ◽  
Enoxaparin Group ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
Therapeutic Doses ◽  
Group 1

<b><i>Introduction:</i></b> The predominant coagulation abnormalities in patients with coronavirus disease 2019 (COVID-19) suggest a hypercoagulable state and are consistent with uncontrolled clinical observations of an increased risk of venous thromboembolism. <b><i>Aim and Objectives:</i></b> To compare the effect of prophylactic versus therapeutic doses of enoxaparin in the treatment of severe cases of COVID-19 infection. <b><i>Materials and Methods:</i></b> This was a retrospective observational study conducted at Latifa hospital, Dubai. Fifty-nine patients enrolled from March to June 2020 and divided into 2 groups: patients who received the prophylactic dose of enoxaparin (group 1) and patients who received the therapeutic dose of enoxaparin (group 2). <b><i>Results:</i></b> The mean age of all cases was 47.2 ± 10.4 years, while the mean weight was 76.4 ± 13.4 kg. Males represented 79.7% of cases. Blood group “O” was the most frequent blood group (40.9%). None of the cases were smokers or using alcohol. Bronchial asthma, lung diseases, diabetes mellitus, hypertension, CKD, cardiac disease, thyroid disease, and immunodeficiency were present in 1.7, 1.7, 39, 27.1, 5.1, 1.7, 5.1, and 1.7% respectively. There was no significant difference between both study groups regarding personal and medical characteristics, except for hypertension where 35.9% of group 2 (therapeutic) cases were hypertensive compared to 10% of group 1 cases (prophylactic). There was a significant difference between both study groups regarding inflammatory markers improvement duration, duration of MV and O<sub>2</sub> support duration, with longer duration among (therapeutic) group 2 cases compared to group 1 cases (prophylactic). There was a highly significant difference between both study groups regarding ICU admission, as 64% of group 1 cases were admitted compared to 25% of group 1 cases. Similarly, 38.5% of group 2 cases needed MV compared to only 10% of group 1 cases, which was statistically significant. There was no significant difference between both groups regarding bleeding tendency and mortality (<i>p</i> value 0.54). <b><i>Conclusion:</i></b> Our results showed that use of prophylactic dose of enoxaparin might have some benefits compared to the therapeutic dose in terms of less duration of ICU and hospital stay, duration of oxygen support, need and duration of MV, and normalization of inflammatory markers. However, there was no significant difference between the 2 regimens regarding the mortality.

scholarly journals Comparison of the Accuracy of Fixture-Level Implant Impression Making with Different Splinting Techniques

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mehrdad Nateghi ◽  
Ramin Negahdari ◽  
Sahar Molaei ◽  
Ali Barzegar ◽  
Sepideh Bohlouli
Keyword(s):  
Setting Time ◽  
Acrylic Resin ◽  
Study Groups ◽  
Significant Difference ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
Main Model ◽  
Group 1

Objectives. The impression-taking technique is one of the most critical factors that not only prevents the shrinkage caused by polymerization but also enhances the accuracy of implant impressions. Also, choosing the right time of taking impressions after splinting implants is one of the important criteria that affects the impression-taking technique. Accordingly, the present study aimed to evaluate the accuracy of different splint methods for implant impressions made at different times. Methods. In this in vitro study, a two-piece metallic index was prepared, and the patient’s jaw was simulated by placing self-cured acrylic resin in the lower part of the index. Then, two holes were made in the acrylic resin at a specific distance from each other, and the analogs were placed in these holes. Splinting of impression copings was carried out with autopolymerized acrylic resin (GC Pattern resin LS, GC America Inc., USA), and an open tray impression approach was performed. Thirty-six casts in three groups (n = 12) were fabricated from the acrylic model. After scanning the casts, the impression accuracy was compared between the three study groups by measuring the distance between the outer portions of the scan bodies screw-retained on implant analogs inside the cast using the Exocad software (2015.07 version). Group 1: splinting impression copings with autopolymerized acrylic resin and impression making immediately after the setting time (4 minutes); group 2: splinting and impression procedure after 17 minutes with splint sectioning and reconnection; group 3: splinting and impression procedure after 24 hours with splint sectioning and reconnection. The data were analyzed using SPSS 17 using the Kruskal–Wallis test. Results. The mean distance measured in group 1 was 19.14 ± 0.029 mm, which was significantly lower than the main model. The distances were 19.15 ± 0.039 and 19.159 ± 0.33 mm in groups 2 and 3, respectively. These two groups were not significantly different from the main model. Moreover, the mean distance measured in the three impression techniques was similar. Conclusions. There was no significant difference in the measurements between group 2, group 3, and the main model. Therefore, dentists can make an impression after 17 minutes to reduce chair time.

scholarly journals Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure

2021 ◽  
Vol 10 (13) ◽  
pp. 2836
Author(s):  
Paulina Kalińczak-Górna ◽  
Kamil Radajewski ◽  
Paweł Burduk
Keyword(s):  
Vitamin D ◽  
Chronic Sinusitis ◽  
Study Groups ◽  
New Information ◽  
Vitamin D Levels ◽  
Before And After ◽  
The Mean ◽  
Group 2 ◽  
Severity Of The Disease ◽  
Group 1

There have been a few reports confirming that vitamin D (VD3) deficiency increases inflammation in the paranasal sinuses. The work brings new information that, despite the presence of inflammation before surgery, patients with higher vitamin D levels had less inflammation, and this has been proven on three levels. We show that vitamin D levels clearly correlate with the severity of the disease in chronic sinusitis. These results have been confirmed in imaging studies (Lund MacKay scale), endoscopy (Lund-Kennedy scale) and in the SNOT 20 questionnaire. 40 patients suffering from chronic sinusitis were divided into two equal groups: group 1: with less severe radiological changes (10 or less points on the Lund-Mackay scale), group 2: with a more advanced form (>10 points). The relationship between VD3 and the severity of the disease (clinical and nasal endoscopy) was assessed. The mean VD3 level in patients in group 2 before surgery was lower (23.01 ng/mL) than in group 1 (28.02 ng/mL) (p < 0.05). They presented a higher degree of advanced changes in all the above scales, i.e., before the SNOT 20 procedure, the mean was: group 1: 30.33, group 2: 31.80 (p < NS); Lund-Kennedy: group 1: 3.21, group 2: 6.30 (p < 0.05). After surgery an increase in VD3 levels was observed in both study groups: in group 1 to the value of 37.98 ng/mL (p < 0.002) and in group 2 to 27.67 ng/mL (p < 0.004). Lower VD3 levels were found in patients with a higher stage of the disease. Reduction of inflammation increases the level of VD3 and reduces subjective and objective symptoms of chronic inflammation.

Sign in / Sign up

Export Citation Format

Share Document