scholarly journals Hipoalbuminemia praoperasi pasien kanker kolorektal terhadap risiko komplikasi pascaoperasi dan lama rawat inap

2013 ◽  
Vol 9 (4) ◽  
pp. 170
Author(s):  
Yohanes Benny ◽  
Teguh Aryandono ◽  
Susetyowati Susetyowati
Keyword(s):  
Colorectal Cancer ◽  
Postoperative Complications ◽  
Length Of Stay ◽  
Cancer Patients ◽  
Significant Risk ◽  
Prognostic Index ◽  
Significant Risk Factor ◽  
Physical Status Classification ◽  
Postoperative Length ◽  
Colorectal Cancer Patients

Background: Malnutrition is most commonly found in gastrointestinal cancer that affects the result of an operation. Albumin serum is an effective and simple way of assessing risk which is associated with malnutrition intensity so that it is generally used as the prognostic index for the development of the incidence of colorectal cancer postoperative complications.Objective: To identify the effect of preoperative hypoalbumin to the incidence of postoperative complications and length of stay of colorectal cancer in patients.Method: The study used the quantitative approach with a nonconcurrent cohort (retrospective analysis) design. The population was patients diagnosed having colorectal cancer who would undergo an operation at Kasih Ibu, Dr. Oen, and Panti Waluyo Hospital of Surakarta. Data analysis used Chi-Square test and logistic regression.Results: Hypoalbumin, either based on admission or pre-operation, was significant risk factor for the incidence of post operative complications in colorectal cancer patients as well as age and American Society of Anesthesiologist Physical Status Classification (ASA) status. The result of multivariate analysis showed age of 20-59 years (OR=2), hypoalbumin based on admission (2.1 times) and preoperation (1.9 times) were risk factors for the incidence of postoperative complication (infection). ASA status III-IV had risk 2.8 times for the incidence of postoperative sepsis complications and 3.7 times for mortality than ASA status I-II. Status of hypoalbumin did not influence total length of stay or postoperative length of stay but age influenced postoperative length of stay.Conclusion: Hypoalbumin influenced the incidence of postoperative complications in colorectal cancer patients, particularly infection complication; whereas factors of age and ASA status were external factors strongly influenced. Hypoalbumin did not influence length of stay. Age was an external factor that strongly influenced postoperative length of stay.

scholarly journals Assessment of the Clinical Usefulness of Preoperative Computed Tomography in Colorectal Cancer Patients Who Received Unplanned Reoperation

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Rui Wang ◽  
Yi Gao ◽  
Jia-Yi Li ◽  
Zhong-Hui Wang ◽  
Qin-qing Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Computed Tomography ◽  
Postoperative Complications ◽  
Cancer Patients ◽  
Ct Imaging ◽  
Preoperative Imaging ◽  
Imaging Evaluation ◽  
Preoperative Ct ◽  
Colorectal Cancer Patients ◽  
Statistical Indicators

Background. In the unplanned reoperation of colorectal cancer patients, computed tomography (CT) is increasingly utilized to locate postoperative complications and previously unlocalized lesions. The purpose of this study is to explore the application of CT in the mortality and complications of the reoperation of colorectal cancer. Patients and Methods. We performed a retrospective review of collected data from the colorectal surgeries of 90 identified colorectal cancer patients who received an unplanned reoperation from 2010 to 2018. Patients were stratified according to those with preoperative CT imaging (CT group, n=36) and those without preoperative CT imaging (NCT group, n=54). Twenty-four statistical indicators of each patient were studied, including their preoperative risk, surgical characteristics, and postoperative outcomes, and satisfaction was evaluated. All data were statistically analysed for predicting postoperative complications by univariate and multivariate logistic regression analyses. Results. Ninety patients received an unplanned reoperation in the study, and 40% (36/90) of these patients underwent preoperative CT examination. Patients’ risk factors were similar between CT and NCT groups. Preoperative imaging was more commonly performed for reoperative new anastomosis + ileostomy but less common for reoperative Dixon’s procedure. The operative duration of the NCT group was longer (139 vs. 104 min, respectively, P=0.01). Preoperative NCT examination (OR 1.24; 95% CI=1.09‐1.42; P=0.01) was an independent predictor of postoperative complications. Importantly, three patients died after an unplanned reoperation for colorectal cancer, which occurred only in the NCT group (5.6% vs. 0.0%, P=0.01). Conclusion. The use of conventional preoperative CT optimizes the choice of the surgical site and the strategy of laparotomy, so as to reduce the length of operation. Preoperative imaging evaluation should be performed for patients undergoing repeat abdominal surgery.

Integrin genetic variants and risk of thromboembolic events in patients with colorectal cancer.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 462-462
Author(s):  
Gerald Prager ◽  
Alexandra Schuler ◽  
Cihan Ay ◽  
Clemens Pausz ◽  
Heinz-Josef Lenz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Venous Thromboembolism ◽  
Cancer Patients ◽  
Tumor Biology ◽  
Multivariable Analysis ◽  
Significant Risk ◽  
Direct Dna Sequencing ◽  
Increased Risk ◽  
Colorectal Cancer Patients ◽  
Integrin Beta 3

462 Background: Patients with colorectal cancer are at increased risk of venous thromboembolism (VTE). Integrin beta-3 are involved in tumor biology as well as platelet aggregation, thus, we tested as a primary endpoint whether a comprehensive panel of germline single nucleotide polymorphisms (SNPs) in the integrin beta-3 gene could predict the risk of VTE in colorectal cancer patients. Methods: The study population comprises patients recruited into the Vienna Cancer and Thrombosis Study (CATS) (Ay, C et al; JCO 2011 vol. 29 no. 15), an ongoing prospective observational cohort study initiated in October 2003 at the Medical University of Vienna. In 114 out of 139 patients diagnosed with colon cancer DNA was assessable for integrin beta-3 germline SNPs rs3809865, rs5918, rs4642 characterization. Whole blood samples were analyzed using PCR-RFLP or direct DNA-sequencing. VTE events were statistical analyzed using one-way Anova testing. Results: The patient’s demographics and tumor characteristics were balanced between groups. VTE occurred in 14 patients (12.28%). In colorectal cancer patients with an rs3809865 A/A allele profile a statistical significant (p=0.0015) increased risk of VTE events was observed as 12 (25%) of 48 patients experienced VTE. Only 2 of 52 patients (3.85%) harboring an A/T allele VTE was diagnosed. None (0%) of the T/T subgroup had any VTE. Other SNPs revealed no predictive value for VTE. In multivariable analysis including age, sex, chemotherapy, and anti-VEGF therapy rs3809865 A/A allele profile remained a statistical significant risk factor for VTE. Conclusions: This study identifies germline polymorphisms in integrin genes as independent prognostic markers for VTE in colorectal cancer. These data may help to select subgroups of patients who may benefit from an enforced prophylaxis of venous thromboembolism (VTE).

scholarly journals The Association Between Modifiable Lifestyle Factors and Postoperative Complications of Elective Surgery in Colorectal Cancer Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lisanne Loogman ◽  
Lindsey C. F. de Nes ◽  
Thea C. Heil ◽  
Dieuwertje E. G. Kok ◽  
Renate M. Winkels ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Postoperative Complications ◽  
Cancer Patients ◽  
Elective Surgery ◽  
Lifestyle Factors ◽  
Colorectal Cancer Patients ◽  
Modifiable Lifestyle Factors
Sign in / Sign up

Export Citation Format

Share Document