scholarly journals Ekstrak air daun Ceplikan (Ruellia tuberosa L) berpengaruh terhadap kadar SGOT, SGPT dan gambaran histologis hepar tikus DM

2011 ◽  
Vol 8 (2) ◽  
pp. 99
Author(s):  
Fitri Ardiani ◽  
Wiryatun Lestariana ◽  
Emy Huriyati
Keyword(s):  
Liver Damage ◽  
Rattus Norvegicus ◽  
Metabolic Disorder ◽  
Liver Histology ◽  
Control Group ◽  
Control Group Design ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Post Test

Background: Diabetes Mellitus (DM) is a chronic metabolic disorder as indicated by hiperglycemia caused by insulin defciency produced by pancreatic islet ß cell which triggers metabolic disorder of carbohydrate, protein and fat, and tends to cause complications. One of the complications is liver damage caused by DM which is probably due to lipid peroxydation, subsequent to free radical production. The common biochemistry signs of liver damage are increasing activities of some enzym such as transaminase pyruvat glutamate serum in the blood. Ruellia tuberosa L is a traditional plant and used by people as diabetic traditional drug. Flavonoid, saponin, zink as antioxidant can decreased of blood glucose in diabetic.Objective: The study aimed to identify the effect of Ruellia tuberosa L extract on glutamate oxaloacetate and glutamate pyruvat transaminases as well as liver histology of diabetic white mice (Rattus norvegicus).Method: The study was pure experimental that used a pre-post test control group design. The study used 30 male Rattus norvegicus. They were divided into 5 groups, each group consisting of 6 rats. Group I rats served as the normal control. Groups II to V consisted of rats with DM induced with alloxan 170 mg/kgBB subcutaneously. The experiment made was as followed. Group I served as control, group II was DM+aquades, group III was DM+Ruellia tuberosa L extract 1.6 mg/ kgBB/day, group IV was DM+Ruellia tuberosa L extract 3.2 mg/kgBB/day, and group V was DM+Ruellia tuberosa L extract 6.4 mg/kgBB/day. Glutamate oxaloacetate and glutamate pyruvat transaminases was measured before beginning and end of the treatment. The blood was taken from sinus orbitalis. At day 30 (end of the study) the rats were sacrifced for their liver. Data of transaminase oxaloacetate glutamate serum and transaminase pyruvat glutamate serum level were analyzed using one way ANOVA. The result of liver histology was analyzed descriptively.Results: The effect of Ruellia tuberosa L extract within 30 days of study could minimize level of transaminase oxaloacetate glutamate serum and transaminase pyruvat glutamate serum of DM rats. Maximal decreasing in extract 3,2 mg. Histologically there was no damage of the liver.Conclusion: Ruellia tuberose L extract could minimize level of transaminase oxaloacetat glutamate serum and transaminase pyruvat glutamate serum of DM and liver histology is normal.

The Quantitative Ultrastructure of the Heart Muscle of Japanese Quail by Hypergravitation, Hypodynamy and Combination

1990 ◽  
Vol 48 (3) ◽  
pp. 188-189
Author(s):  
Anton Bózner ◽  
Mikuláš Gažo ◽  
Jozef Dostál
Keyword(s):  
Japanese Quail ◽  
Heart Muscle ◽  
Relative Size ◽  
Combination Group ◽  
Control Group ◽  
Group V ◽  
Group Iii ◽  
Space Flights ◽  
Group I ◽  
Quantitative Ultrastructure

It is anticipated that Japanese quail /Coturnix coturnix japonica/ will provide animal proteins in long term space flights. Consequently this species of birds is of research interest of international space program INTERCOSMOS. In the year 1987 we reported on an experiment /2/ in which the effect of chronic acceleration of 2 G hypergravitation, the hypodynamy and the simultaneous effect of chronic acceleration and the location in the centre of the turntable of the centrifuge on the protein fractions in skeletal muscles was studied. The ultrastructure of the heart muscle was now in this experiments examined as well.Japanese quail cockerels, aged 48 days were exposed to 2 G hypergravitation /group IV/ in a 6,4 m diameter centrifuge, to hypodynamy /group III/ and their combination /group V/, respectively for 6 days / Fig.1/. The hypodynamy in group III was achieved by suspending the birds in jackets without contact the floor. The group II was located in the centre ofthe turntable of the centrifuge. The control group I. was kept under normal conditions. The quantitative ultrastructure of myocard was evaluated by the methods of Weibel/3/ - this enables to determine the number, relative size and volume of mitochondria volume of single mitochondria, defficiency of mitochondrial cristae and volume of myofibrils.

Pengaruh Pemberian Ekstrak Rumput Laut Merah (Kappaphycus alvarezii) terhadap Kadar LDL Pada Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar Yang Diberi Diet Tinggi Lemak

2018 ◽  
Vol 15 (2) ◽  
pp. 112
Author(s):  
MENTARI AMENDA SAPUTRI ◽  
HERIN SETIANINGSIH
Keyword(s):  
Rattus Norvegicus ◽  
Kappaphycus Alvarezii ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
One Way Anova ◽  
Test Control

<p class="Default">Penyakit kardiovaskular merupakan penyebab kematian nomor satu di dunia. Gaya hidup masyarakat terutama dalam mengkonsumsi diet yang tidak sehat dapat meningkatkan kadar LDL yang dapat menyebabkan  penyakit kardiovaskular. Rumput laut merah (<em>Kappaphycus alvarezii</em>)<em> </em>yang banyak dibudidayakan di Indonesia mengandung flavonoid dan triterpenoid yang diduga dapat menurunkan kadar LDL. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) <em> </em>terhadap kadar LDL pada tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang diberi diet tinggi lemak. Penelitian ini adalah penelitian eksperimental murni laboratorik dengan rancangan penelitian <em>Post Test Control Group Design. </em>Sampel yang digunakan adalah 24 ekor tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang dibagi ke dalam tiga kelompok: kelompok yang diberi diet standar selama 28 hari (K1), kelompok yang diberi diet tinggi lemak selama 28 hari (K2), dan kelompok yang diberi diet tinggi lemak selama 28 hari dan pada hari ke-15 sampai hari ke-28 diberi ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) dengan dosis 140mg/200grBB/hari (K3). Hasil analisis statistik <em>One Way Anova </em>menunjukkan bahwa terdapat perbedaan kadar LDL yang signifikan antara ketiga kelompok pada penelitian ini (p&lt;0,001). Kadar LDL pada K2 (=16,00±3,29) meningkat secara bermakna dibandingkan dengan K1 (=10,62±1,77). Sedangkan kadar LDL pada K3 (=6,88±2,42) menurun secara bermakna dibandingkan dengan K2. Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) berpengaruh terhadap kadar LDL darah pada tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang diberi diet tinggi lemak.</p><p><strong>Kata kunci</strong> : diet tinggi lemak, LDL, <em>Kappaphycus alvarezii</em></p>

A Study on the Effect of Samoa Extract (Cleome droserifolia) on Sperm Quality in Male Albino Rats Exposed to Pyrethroid

2021 ◽  
pp. 39-45
Author(s):  
Nura I. Al-Zail ◽  
Salah F. Kamies
Keyword(s):  
Sperm Quality ◽  
Group Iv ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Protective Agent ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Induced Changes

Pyrethroid cyhalothrin (PC) is an insecticide that is used worldwide for pest control in agriculture and household use. Samoa extract (SE) is a potent antioxidant protecting cells from oxidative stress. The present study investigates the protective and therapeutic effect of SE on PC-induced changes in sperm quality in male rats. Fifty adult male albino rats were divided into five groups: group I: served as control; group II: received PC i.p. only (6.2 mg/kg b.wt.); group III: received SE only (100 mg/kg b.wt., p.o.) for eight weeks; group IV: received SE as a protective agent daily for eight weeks, then followed by the administration of PC (i.p.) three times a week for two weeks; group V: exposed to PC (i.p.) three times a week for two weeks, then treated with the SE daily for 8 weeks. Results showed that PC caused markedly impaired sperm quality (a count, viability, motility, and abnormality). Compared to PC-treated animals, SE in the protective group markedly restored the alteration of sperm indices. However, SE in the curative group was found to be less effective in restoring PC-induced alterations. In conclusion, the data of this study revealed that the SE as a protective agent is more effective than as a therapeutic agent. Keywords: Samoa; Pyrethroid; Sperm quality; Rat

scholarly journals EFEK PEMBERIAN SEDUHAN SELEDRI (APIUM GRAVEOLENS L.)TERHADAP KADAR ASAM URAT PADA TIKUS PUTIH JANTAN STRAIN WISTAR (RATTUS NORVEGICUS) HIPERURISEMIA

2017 ◽  
Vol 9 (2) ◽  
pp. 75
Author(s):  
Reni Deviandra ◽  
Fathiyah Safitri ◽  
Djaka Handaja
Keyword(s):  
Rattus Norvegicus ◽  
Apium Graveolens ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Test Control

Efek Pemberian Seduhan Seledri (Apium graveolens L.)Terhadap Kadar Asam Urat Pada Tikus Putih Jantan Strain Wistar (Rattus norvegicus) Hiperurisemia. Latar Belakang: Salah satu jenis tanaman yang diduga dapat menurunkan kadar asam urat adalah seledri. Seledri mengandung flavonoid dan 3-n butylphtalide (3nB) dapat menurunkan kadar asam urat dengan menghambat kerja enzim xantin oksidase. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh seduhan seledri (Apium graveolens L.) terhadap penurunan kadar asam urat pada tikus putih jantan hiperurisemia. Metode Penelitian: Menggunakan eksperimental murni, dengan rancangan Randomized Post Test Control Group Design. Sampel penelitian dibagi menjadi 5 kelompok. Kelompok I: Kontrol positif (Saripati hati ayam mentah 3 ml/150grBB selama 21 hari + pakan normal selama 7 hari), II, III dan IV: diberikan Saripati hati ayam mentah 3 ml/150grBB selama 21 hari + seduhan seledri dengan dosis 50, 100, 150mg/ekor/hari selama 7 hari, V: Kontrol negatif (Pakan normal selama 28 hari). Pengukuran kadar asam urat dengan menggunakan metode kolometrik enzimatik. Hasil: Hasil pengukuran asam urat kelompok dengan pemberian seduhan seledri dosis 150 mg/ekor/hari menunjukkan kadar asam urat paling rendah (4,679±0,687) dibanding dengan kelompok kontrol positif menunjukkan kadar asam urat paling tinggi (11,563±1,541). Kesimpulan: Ada hubungan antara dosis seduhan seledri (Apium graveolens L.) terhadap kadar asam urat pada tikus putih jantan (Rattus Norvegicus) hiperurisemia.Kata Kunci: Seledri, Hiperurisemia, Kadar Asam Urat, Saripati Hati Ayam,

scholarly journals Dosis Efektif Enoxaparin dalam Mencegah Terjadinya Trombosis pada Anastomosis Arteri Femoralis Tikus

2017 ◽  
Vol 1 (2) ◽  
pp. 34
Author(s):  
I Made Suka Adnyana ◽  
Iswinarno Doso Saputro
Keyword(s):  
Free Flap ◽  
Rattus Norvegicus ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Wistar Strain ◽  
Post Test

Tujuan: untuk mengetahui dosis efektif enoxaparin dalam mencegah terjadinya trombosis pada anastomosis mikrovaskular. Metode: penelitian ini bersifat eksperimental dengan rancangan the randomized post test only control group design. Terdapat 33 tikus jantan Rattus norvegicus Wistar strain yang dikelompokkan menjadi tiga perlakuan yaitu perlakuan A (enoxaparin 0,75 mg/kg), B (enoxaparin 1  mg/kg), dan C (kontrol). Tuck model anastomosis dilakukan pada arteri femoralis, kemudian luas trombus yang terjadi pada pembuluh darah dibandingkan dengan diameter lumen pembuluh darah diukur dengan graticule lens dan dinyatakan dalam persen. Hasil: trombus terbentuk pada semua subyek penelitian baik pada kelompok perlakuan maupun kontrol. Rerata persentase luas trombus pada kelompok enoxaparin 0,75 mg/kg adalah 24,3%, enoxaparin 1 mg/kg sebesar 19,8% dan kelompok NaCl 0,9% sebesar 79,4%. Terdapat perbedaan antara perlakuan pemberian enoxaparin dosis 0,75 mg/kg dan 1 mg/kg dengan kontrol, namun tidak ada perbedaan bermakna rerata persentase luas trombus diantara kelompok enoxaparin dosis 0,75 mg/kg dan dosis 1 mg/kg (p=0,624). Perlu dilakukan penelitian secara klinis guna melihat efektivitas enoxaparin dalam meningkatkan patensi anastomosis pada free flap maupun replantasi. Simpulan: pemberian enoxaparin dosis 0,75 mg/kg dan enoxaparin dosis 1 mg/kg secara subkutan efektif mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus. Tidak terdapat perbedaan efektivitas yang bermakna dalam mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus setelah diberikan dosis enoxaparin 0,75 mg/kg dan 1 mg/kg secara subkutan.

scholarly journals Comparative Evaluation of Apical Sealing Ability of Different Obturation Techniques by Confocal Microscopy: An In Vitro Study

2020 ◽  
Vol 8 (02) ◽  
pp. 55-59
Author(s):  
Reetu Arora ◽  
Yogesh Kumar ◽  
Neetu Jindal ◽  
Renu Aggarwal ◽  
Kavneet Takhar
Keyword(s):  
Root Canal ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Group Iv ◽  
Control Group ◽  
Group Vi ◽  
Group V ◽  
Group Iii ◽  
Group I

Abstract Introduction The aim of obturation in the root canal is to completely seal the canal space to eliminate all the portals of entry and exit between root canal and periodontal space. Various techniques have been developed to achieve a hermetic seal. Materials and Methods As many as 150 extracted human maxillary central incisors were taken for the study. Biomechanical preparation was done up to F5 protaper file. According to different obturation techniques, samples were divided into six groups, keeping 30 samples in experimental and 15 samples in control groups. Group I–Lateral Condensation, Group II–Thermafil, Group III–Beefill, Group IV–GuttaFlow, Group V–Positive Control group, Group VI–Negative Control group. After obturation, the samples were immersed in 2% Rhodamine-B dye for 24 hours. Each sample was longitudinally sectioned to examine under confocal laser scanning microscope. Statistical Analysis The results were evaluated with ANOVA and posthoc Tukey honest significant difference (HSD) comparison test. Results The mean values of dye penetration of different groups were Group I (Lateral Condensation) 1.51 ± 0.451, Group II (Thermafil) 0.918 ± 0.399, Group III (Beefill) 1.30 ± 0.559. Group IV (GuttaFlow) 0.655 ± 0.396, Group V (Positive Control group) 1.96 ±0.046, Group VI (Negative Control group) 0 ± 0. The lowest mean value of apical microleakage was found in GuttaFlow amongst all experimental groups. Conclusion It can be concluded that the GuttaFlow obturating material exhibited better apical sealing ability with canal walls.

scholarly journals Comparative Evaluation between Sulfasalazine Alone and in Combination with Herbal Medicine on DSS-Induced Ulcerative Colitis Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mi-Rae Shin ◽  
Kyeong Jo Kim ◽  
Soo Hyun Kim ◽  
Su Ji Kim ◽  
Bu-Il Seo ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Comparative Evaluation ◽  
Control Group ◽  
Inflammatory Infiltration ◽  
Group V ◽  
Group Iii ◽  
Protein Levels ◽  
Group I ◽  
Apoptotic Protein ◽  
Mitogen Activated Protein

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and sulfasalazine in combination with herbal medicine on dextran sodium sulfate- (DSS-) induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n=9): Group I (normal group), Group II (DSS control group), Group III (DSS + sulfasalazine (30 mg/kg)), Group IV (DSS + sulfasalazine (60 mg/kg)), and Group V (DSS + sulfasalazine (30 mg/kg) + Cinnamomi Cortex and Bupleuri Radix mixture (30 mg/kg) (SCB)). Colonic pathological changes were analyzed using hematoxyline/eosin staining. The antioxidant, inflammatory, and apoptotic protein levels were determined using western blotting. SCB supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SCB treatment significantly reduced the expression of proinflammatory signaling molecules through suppression of both mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways and prevented the apoptosis of the colon. Moreover, SCB administration significantly led to the upregulation of antioxidant enzymes including SOD and catalase. Taken together, SCB treatment might offer a better treatment for human UC than sulfasalazine alone or may be useful as an alternative therapeutic strategy against UC, without any evidence of side effects.

The Effect of Parathion-methyl and Antidotes on Parotid and Pancreatic Glands: A Pilot Experimental Study

2007 ◽  
Vol 26 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Betul Gulalp ◽  
Yuksel Gokel ◽  
Derya Gumurdulu ◽  
Gulsah Seydaoglu ◽  
Kenan Daglioglu ◽  
...  
Keyword(s):  
Group Iv ◽  
Control Group ◽  
Blood Levels ◽  
Parotid Glands ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Histopathologic Evaluation ◽  
Histologic Changes

The objective of this study is to investigate the functions of parotid and pancreatic glands in response to intoxication with parathion-methyl (PM) and the effects of treatment in rats. Seventy-five male Wistar rats were divided equally into five groups: Group I, control; group II, received atropine and pralidoxime (2-PAM) for 24 h, but no PM; group III, oral PM but no atropine and 2-PAM; group IV, PM and atropine for 24 h and 2-PAM; group V, PM and atropine for 96 h and 2-PAM. After the administration of the chemicals, blood samples were drawn to test for amylase, lipase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), while pancreatic and parotid glands of each rat were removed for light microscopic examination. Amylase levels were found significantly elevated in groups II, III, IV, and V, whereas lipase levels were supranormal in groups III, IV, and V. The blood levels of AChE were decreased in groups III and IV and BChE were decreased in II, III, IV, and V. No evidence of pancreatitis and parotitis was identified in the histopathologic evaluation in any group in 96 h; however, hyperchromasia, irregularity in nuclei, and binuclear cells were observed in all parotid glands in group V. Parotitis and pancreatitis were not evident; however, hyperamylasemia and hyperlipasemia were found, whereas various histologic changes in parotid glands were documented in the groups that were administered organophosphate and treatment.

scholarly journals UJI EFEK ANALGETIK DAN ANTIINFLAMASI EKSTRAK ETANOL 70% DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) PADA TIKUS PUTIH (Rattus novergicus)

Media Farmasi ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 118
Author(s):  
Amran Nur ◽  
Dedi Ma’ruf ◽  
Ira Widya Sari ◽  
Natsir Djide ◽  
Peter Kabo
Keyword(s):  
Rattus Norvegicus ◽  
Control Group ◽  
Control Group Design ◽  
Writhing Test ◽  
Group Design ◽  
Post Test ◽  
Test Control

Uji efek analgetik dan antiinflamasi ekstrak etanol 70% daun beruwas laut (Sacevola taccada. Gartn.) Roxb) terhadap Tikus Putih (Rattus norvegicus) Jantan. Penelitian ini bertujuan menentukan efek analgetik dan antiinflamasi esktrak etanol 70% daun beruwas laut (Sacevola taccada. Gartn.) Roxb) terhadap Tikus Putih (Rattus norvegicus) Jantan. Penelitian ini adalah  penelitian eksperimental dengan pendekatan pre dan post test control group design. Sampel dibagi dalam 6 kelompok, yaitu kelompok normal, kontrol negatif, kontrol positif, dan kelompok ekstrak. Pada kelompok ekstrak, menggunakan 3 dosis ekstrak yang berbeda yaitu ekstrak dosis 12,5 mg/kgBB, 25 mg/kgBB, dan 37,5 mg/kgBB. Penentuan analgetik dengan metode Writhing test yang diinduksi dengan asam asetat 1% sedangkan antiinflamasi dengan pembentukan edema buatan dengan penginduksi karagen 1%. Efek analgetik dan antiinflamasi diperoleh pada ekstrak etanol 70% daun beruwas laut (Scaevola taccada (Gaertn.) Roxb) dengan dosis 12,5 mg/kgBB, 25 mg/kgBB, dan 37,5 mg/kgBB yang ditandai dengan jumlah geliatan dan radang pada kaki yang berbeda dengan kelompok kontrol. Hasil analisis statistik menggunakan metode SPSS (Statistical Product and Service Solution) menunjukkan bahwa efek analgetik dan antiinflamasi diperlihatkan oleh Ekstrak etanol 70% daun beruwas laut (Scaevola taccada (Gaertn.) Roxb). dosis 12,5 mg/kgBB, 25 mg/kgBB, dan 37,5 mg/kgBB tidak berbeda nyata dengan asam mefenamat dan natrium diklofenak.

scholarly journals Pengaruh Terapi Oksigen Hiperbarik 2,4 ATA 3X30 Menit 5 Sesi terhadap Kadar Testosteron pada Tikus Model Sindroma Ovarium Polikistik dengan Resistensi Insulin

2020 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Fajar Sudiono ◽  
Lunardhi Susanto ◽  
Wachjudi Kurnia
Keyword(s):  
Rattus Norvegicus ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test

<h1>ABSTRAK</h1><p><strong>Latar Belakang:</strong>Sindroma ovarium polikistik (SOPK) adalah suatu kelainan endokrin yang mempunyai spektrum gambaran yang luas dan paling sering timbul pada wanita usia reproduktif. Faktor yang mendasari terjadinya SOPK adalah androgen yang berlebih, resistensi insulin, dan gangguan dinamika gonadotropin. Androgen yang berlebih menyebabkan ketidak seimbangan LH dan FSH. Terapi oksigen hiperbarik menurut teori dapat meningkatkan sensitivitas jaringan terhadap insulin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh terapi okssigen hiperbarik 2,4 ATA 3x30 menit selama 5 sesi terhadap kadar testosterone pada tikus model Sindroma Ovarium Polikistik dengan resistensi insulin.</p><p><strong>Metode</strong>:Penelitian ini merupakan penelitian eksperimental sejati dengan <em>post test only control group design. </em>Besar sampel yang digunakan sebanyak 12 ekor yang terbagi menjadi 2 kelompok. Variabel bebas pada penelitian adalah terapi oksigen hiperbarik, variabel terikatnya yaitu kadar testosteron pada sampel darah tikus putih dan variabel controlnya suhu ruang dan pakan standart serta variabel kendalinya injeksi androgen, jenis dan spesifikasi hewan coba, ukuran kandang dan perawatan hewan. Analisis data penelitian ini diolah menggunakan uji Uji <em>Mann Whitney U.</em></p><p><strong>Hasil:</strong>Hasil data menggunakan Uji <em>Mann Whitney U</em> menunjukkan tidak ada perbedaan antara Kadar testosteron kelompok hewan coba yang diberi injeksi androgen dengan kelompok hewan coba yang diberi injeksi androgen dan terapi oksigen hiperbarik.</p><p><strong>Kesimpulan:</strong>Pemberian terapi oksigen hiperbarik tidak berpengaruh terhadap Kadar testosterone pada kelompok tikus putih <em>(Rattus Norvegicus)</em> model Sindrom ovarium polikistik dengan resistensi insulin.</p><p> </p><strong>Kata kunci: </strong><em>Terapi oksigen hiperbarik, Kadar testoteron, Sindroma ovarium polikistik, Resistensi insulin</em>

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