scholarly journals Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent

2020 ◽  
Vol 20 (5) ◽  
pp. 987
Author(s):  
Nurzaimah Zaini @ Othman ◽  
Nor Suhaila Mohamad Hanapi ◽  
Nor’ashikin Saim ◽  
Wan Nazihah Wan Ibrahim ◽  
Ahmad Lutfi Anis
Keyword(s):  
Solid Phase Extraction ◽  
Water Samples ◽  
Solid Phase ◽  
Tap Water ◽  
Phase Extraction ◽  
Online Spe ◽  
Selective Determination ◽  
Acidic Drugs ◽  
Multi Walled Carbon Nanotubes

A rapid and effective method is developed for selective determination of five selected acidic drugs (salicylic acid, naproxen, diclofenac, ibuprofen and mefenamic acid) in water samples by using online solid phase extraction (Online-SPE) prior to liquid chromatography diode array detector (LC-DAD) analysis. In this study, Alginate incorporated multi-walled carbon nanotubes (Alg-MWCNT) beads were prepared and utilized as solid phase extraction sorbent. Optimization of online SPE-LC operating parameters such as valve switching time, composition of acetonitrile and buffer pH was conducted using Box-Behnken Design of Response Surface Methodology (RSM) to evaluate the interactive effects of these three variables. Under the optimized conditions (valve switching time: 1.5 min, composition of acetonitrile: MSA, 60:40 and buffer pH: pH 2), the method showed good linearity (1–500 μg L−1) with coefficient of determination (R2) of 0.9971–0.9996 and low limits of detection ≤ 0.018 µg L–1. The method showed high relative recoveries in the range of 75–110% for river water and tap water samples, respectively with RSDs of ≤ 7.8 (n = 3). This method was successfully applied to the determination of acidic drugs in river and tap water samples. In addition, Alg-MWCNT sorbent offered high degree of selectivity and efficiency for online SPE-LC-DAD analysis.

scholarly journals Selective determination of penicillin G from tap water and milk samples using surface molecularly imprinted polymers as solid-phase extraction sorbent

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Wei Du ◽  
Huiyan Zhou ◽  
Zhimin Luo ◽  
Penglei Zheng ◽  
Pengqi Guo ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Tap Water ◽  
High Rate ◽  
Penicillin G ◽  
Phase Extraction ◽  
Selective Determination ◽  
Milk Samples ◽  
Molecularly Imprinting Polymers

AbstractIn this study, a selective sample preparation method coupling surface molecularly imprinting polymers (SMIPs) with solid-phase extraction (SPE) was developed for the determination of penicillin G from tap water and milk samples. SMIPs for penicillin G were synthesized by using silica gel as supporting matrix, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EDMA) as the cross-linker, methanolacetonitrile (1:1,v/v) as the solvents and 2,2′-azo-bisisobutyronitrile (AIBN) as the initiator. Characterization and adsorption experiments revealed that SMIPs exhibited large adsorption capacity, high recognition ability and high rate of mass transfer. Application of SMIPs in SPE followed by HPLC was done to selectively determine penicillin G from tap water and milk samples. Under the optimal conditions, the proposed method demonstrated high linearity with the concentration of penicillin G ranging from 0.12 to 200 μg mL

Multi-walled carbon nanotubes-agarose gel micro-solid phase extraction for the determination of triazine herbicides in water samples

2015 ◽  
Vol 7 (6) ◽  
pp. 2862-2868 ◽  
Author(s):  
Mohd Marsin Sanagi ◽  
Mohamad Nazirul Muzakkir Mat Jais ◽  
Sazlinda Kamaruzaman ◽  
Wan Aini Wan Ibrahim ◽  
Umair Baig
Keyword(s):  
Carbon Nanotubes ◽  
Solid Phase Extraction ◽  
Water Samples ◽  
Solid Phase ◽  
Agarose Gel ◽  
Phase Extraction ◽  
Triazine Herbicides ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

A new extraction procedure termed multi-walled carbon nanotubes-agarose gel micro-solid phase extraction (MWCNTs-AG-μSPE) combined with GC-MS was used for the determination of triazine herbicides in water samples.

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