scholarly journals SYNTHESIS OF THIOMETHYLATED CALIX[4]RESORCINARENE BASED ON FENNEL OIL VIA CHLOROMETHYLATION

2011 ◽  
Vol 11 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Suryadi Budi Utomo ◽  
Jumina Jumina ◽  
Dwi Siswanta ◽  
Mustofa Mustofa ◽  
Naresh Kumar
Keyword(s):  
Melting Point ◽  
Sodium Hydroxide ◽  
1H Nmr ◽  
Sodium Hydroxide Solution ◽  
Starting Material ◽  
Cone Conformation ◽  
Hydroxide Solution ◽  
Partial Cone ◽  
Ft Ir ◽  
Fennel Oil

A research has been conducted to synthesize thiomethylated-C-4-methoxyphenylcalix[4]resorcinarene using fennel oil as a starting material. The synthesis was carried out in four steps i.e. (1) oxidation of anethole to yield p-anisaldehyde, (2) HCl-catalyzed condensation of p-anisaldehyde with resorcinol, (3) chloromethylation of C-4-methoxyphenylcalix[4]resorcinarene with paraformaldehyde and HCl in the presence of ZnCl2 to yield tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene, and (4) reaction of tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene with thiourea followed by hydrolysis with sodium hydroxide solution to yield tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene. The prepared compounds were characterized based on melting point, FT-IR, and NMR spectrometers. According to the analysis of 1H-NMR spectrometer, C-4-methoxyphenylcalix[4]resorcinarene and tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene were observed in the chair or flattened partial cone conformation, while tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene tend to exist in the crown or cone conformation.

scholarly journals Synthesis, Anticonvulsant and Neurotoxicity Screening of Some Novel 2, 5-Disubstituted - 1, 3, 4 � Oxadiazole Derivatives

2017 ◽  
Vol 9 (01) ◽  
Author(s):  
Y. Khatoon ◽  
M. Shaquiquzzaman ◽  
V. Singh ◽  
M. Sarafroz
Keyword(s):  
Sodium Hydroxide ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Neurological Deficit ◽  
Anticonvulsant Activity ◽  
Sodium Hydroxide Solution ◽  
Maximal Electroshock ◽  
Rota Rod Test ◽  
Oxadiazole Derivatives ◽  
Ft Ir

A series of 2, 5-disubstituted - 1, 3, 4 oxadiazoles (4a-o) were synthesized on refluxing hydrazine carbothioamides with iodine and potassium iodide in ethanolic sodium hydroxide solution starting from methyl-3-amino-4-hydroxy benzoate via synthesis of an intermediate methyl-2-substitutedaryl-1, 3-benzoxazole-5-carboxylates and 2-substitutedaryl-1, 3-benzoxazole-5-carbohydrazides. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H-NMR, MS) and elemental analysis. All these compounds were screened for anticonvulsant activity using Maximal Electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) method. Anticonvulsant activity was shown by majority of the synthesized compounds when given i.p. to mice. Among the tested compounds 4e, 4j and 4o were considered to have potent anticonvulsant activity comparable to that of standard drugs Phenytoin and Carbamazepine. Compounds 4e, 4g, 4h, 4i, 4k and 4m passed the rota rod test successfully without any sign of neurological deficit.

The preparation of sodium 4-Amino-3-nitro-benzenesulfonate and some related compounds

1982 ◽  
Vol 35 (8) ◽  
pp. 1727 ◽  
Author(s):  
J Rosevear ◽  
JFK Wilshire
Keyword(s):  
Sodium Hydroxide ◽  
Nitro Group ◽  
Sodium Salt ◽  
Sulfonic Acid ◽  
Sodium Hydroxide Solution ◽  
Hydroxide Solution ◽  
Dilute Sodium Hydroxide ◽  
Related Compounds

The sodium salt of 4-amino-3-nitrobenzenesulfonic acid (O-nitroaniline-p-sulfonic acid) has been prepared by the action of dilute sodium hydroxide solution on ethyl [(4-chlorosulfonyl-2-nitro)- phenyllcarbamate. Central to this synthesis is the finding that the N-ethoxycarbonyl group, when located ortho to a nitro group (but not to a bromo group), is readily removed by dilute sodium hydroxide solution.

Kinetics and leaching behaviors of aluminum from pharmaceutical blisters in sodium hydroxide solution

2015 ◽  
Vol 22 (12) ◽  
pp. 4545-4550 ◽  
Author(s):  
Chong-qing Wang ◽  
Hui Wang ◽  
Guo-hua Gu ◽  
Jian-gang Fu ◽  
You-nian Liu
Keyword(s):  
Sodium Hydroxide ◽  
Sodium Hydroxide Solution ◽  
Hydroxide Solution

scholarly journals Reconstruction of the Esophagus in a Patient who Attempted Suicide by Swallowing Sodium Hydroxide Solution -Utility of DP Flap -

1997 ◽  
Vol 1997 (Supplement94) ◽  
pp. 217-225
Author(s):  
Tatsuya Fujiyoshi ◽  
Hiroyuki Masuda ◽  
Tokuji Nishinaka ◽  
Tetsuo Futami ◽  
Hiromi Shibuya
Keyword(s):  
Sodium Hydroxide ◽  
Attempted Suicide ◽  
Sodium Hydroxide Solution ◽  
Hydroxide Solution

scholarly journals PRODUÇÃO DE CELULASES E XILANASE POR Aspergillus niger IZ9 USANDO FERMENTAÇÃO SUBMERSA SOBRE BAGAÇO DE CANA-DE-AÇÚCAR

2000 ◽  
Vol 18 (1) ◽  
Author(s):  
CLAUDIO LIMA AGUIAR ◽  
TOBIAS J. B. MENEZES
Keyword(s):  
Aspergillus Niger ◽  
Phosphoric Acid ◽  
Sodium Hydroxide ◽  
Sugarcane Bagasse ◽  
Sodium Hydroxide Solution ◽  
Cellulolytic Enzymes ◽  
Hydroxide Solution ◽  
Chemically Treated

Avaliou-se a produção de celulases e xilanase de Aspergillus niger IZ9, crescido sobre bagaço de cana, quimicamente tratado, como substrato. Os tratamentos foram: solução de hidróxido de sódio a 4%, e solução de hidróxido de sódio a 4%, ácido fosfórico p.a. e vapor. A produção das enzimas celulolíticas (celulase total, endoglicanase e ­glicosidase) e xilanase foi observada nos bagaços tratados e nãotratado. O tratamento com solução de hidróxido de sódio a 4% promoveu maior indução de síntese da maioria das enzimas, com exceção de ­glicosidase, a qual apresentou produção semelhante para os bagaços tratados quimicamente. Abstract It was evaluated the production of cellulases and xylanase by Aspergillus niger IZ09 grown in a substrate consisted of chemically treated sugarcane bagasse. The treatments were: 4% sodium hydroxide solution and 4% sodium hydroxide solution, phosphoric acid and steam. The production of the cellulolytic enzymes (total cellulase, endoglycanase and B.CEPPA, Curitiba, v. 18, n. 1, jan./jun.2000 67 ­glucosidase) and xylanase was observed in the treated and nontreated bagasses. The treatment with 4% sodium hydroxide solution promoted a greater induction of the synthesis of the majority of the enzymes, with exception of ­glucosidase, which showed similar production for both chemically treated bagasses.

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