scholarly journals QUINOLIN-6-AMINES: SYNTHESIS AND BIOLOGICAL EVALUATION

2013 ◽  
Vol 13 (3) ◽  
pp. 185-192
Author(s):  
Hament Panwar ◽  
Nidhi Chaudhary ◽  
Ranjana Dubey ◽  
Tilak Ram
Keyword(s):  
1H Nmr ◽  
Biological Evaluation ◽  
Mass Analysis ◽  
Synthesis And Biological Evaluation

Some novel 2-{(chloromethoxy)methyl}thio-N-substituted phenyl-[1,2,4]triazolo[1,5-a] quinolin-6-amines have been derived from 5-bromocoumarin. All the synthesized compounds have been characterized by elemental and spectral (I.R., 1H-NMR, Mass) analysis and evaluated for their antimicrobial, insecticidal and anthelmintic activities.

Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

2008 ◽  
Vol 59 (4) ◽  
Author(s):  
Gabriela Laura Almajan ◽  
Stefania Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Mihaela Dinu ◽  
Cristian Vasile Doicin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
Low Concentrations ◽  
Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HETEROCYCLES CONTAINING OXADIAZOLE AND PYRAZOLE RING FOR ANTI-BACTERIAL, ANTI-FUNGAL AND ANTI-TUBERCULAR ACTIVITIES

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (03) ◽  
pp. 18-24
Author(s):  
S. R. Pattan ◽  
◽  
P. A Chavan ◽  
R. A Muluk ◽  
S. S Dengale ◽  
...  
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Ethyl Acetoacetate ◽  
Pyrazole Ring ◽  
Biological Evaluation ◽  
Secondary Amines ◽  
Anti Fungal ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

1, 3, 4-oxadiazoles were synthesized by treating pyrazine-2-carbohydrazide with CS2 and alc. KOH and their derivatives were prepared by using R-Cl compounds. pyrazolones were synthesized by treatingpyrazine-2-carbohydrazide with ethyl acetoacetate. The derivatives of pyrazolone were prepared by refluxing pyrazolone with formaldehyde and different substituted secondary amines. All the synthesized compounds were characterized by IR, 1H-NMR and elemental analysis and evaluated for antibacterial, antifungal and antitubercular activities.

Design, Synthesis, and Biological Evaluation of Sorafenib Analogs Bearing a Sulfonylurea Unit as Novel VEGFR2 Kinase Inhibitors

2014 ◽  
Vol 989-994 ◽  
pp. 1048-1051 ◽  
Author(s):  
Wu Fu Zhu ◽  
Chun Jiang Wu ◽  
Shan Xu ◽  
Wei Li ◽  
Hai Hong Fang ◽  
...  
Keyword(s):  
1H Nmr ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Inhibition Rate ◽  
Design Synthesis ◽  
Chemical Structures ◽  
Synthesis And Biological Evaluation

Two sorafenib analogs (9a,9b) containing sulfonylurea unit were synthesized and their chemical structures were confirmed by 1H NMR and MS spectrum. The synthesized compounds were evaluated for the inhibition rate against VEGFR2 kinase at 10μM level. The inhibition rates of compound 9a and 9b against VEGFR2 kinase were 61.0±11.1% and 22.6±2.6%, respectively. The results showed that the introduction of sulfonylurea unit is favorable for the activity, and further study is being carried out.

scholarly journals Synthesis and Biological evaluation of some new 2-thioxoimidazolidin-4-one derivatives (part II)

2018 ◽  
Vol 29 (1) ◽  
pp. 79 ◽  
Author(s):  
Amjad Gali
Keyword(s):  
Antibacterial Activity ◽  
1H Nmr ◽  
Heterocyclic Compounds ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
In Series ◽  
Cyclic Compounds ◽  
Synthesis And Biological Evaluation

In the present work adifferent of new heterocyclic  compounds were synthesized by reaction of thiosemicarbazide with tow aldehydes (4-bromo benzaldehyde,2-chloro benzaldehyde). the reacting `of compounds(1,2)  with ethyl chloroacetate to give 3-[(arylidene)amino]-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one (3,4) which treating with defferent aldehydes togive chalcones  . the compound (3) reacted with ethyl aceto acetate to give ethyl 4-aryl-1-[(4-bromo benzylidene)amino]-6-oxo-2-sulfanyl-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-5-carboxylate,and in series of reaction converted into a variety of derivatives. The prepared compounds were characterized by 1H NMR and FTIR spectroscopy.further more antibacterial activity of some the prepared  new cyclic compounds were evaluated against three types of bacteria

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