scholarly journals Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

2015 ◽  
Vol 15 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Sari Edi Cahyaningrum ◽  
Nuniek Herdyastuti ◽  
Nur Qomariah
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Calcium Alginate ◽  
Particle Diameter ◽  
Synthesis And Characterization ◽  
Release Mechanism ◽  
Release Kinetic ◽  
And Diffusion ◽  
Drug Release Kinetic

The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug. The microparticles were evaluated for surface morphology, functional groups, size particles, drug content and swelling index. The drug release kinetic was investigated at gastric and intestinal artificial pH. The results showed that isoniazid-calcium alginate-chitosan has majority particle diameter of 1001-1500 nm. The release mechanism of isoniazid was through combination of erosion and diffusion.

scholarly journals Design and evaluation of lornoxicam bilayered tablets for biphasic release

2012 ◽  
Vol 48 (4) ◽  
pp. 609-619
Author(s):  
Songa Ambedkar Sunil ◽  
Meka Venkata Srikanth ◽  
Nali Sreenivasa Rao ◽  
Sakamuri Balaji ◽  
Kolapalli Venkata Ramana Murthy
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Release Kinetic ◽  
Burst Release ◽  
Significant Difference ◽  
Biphasic Release

The objective of the present investigation was to develop bilayered tablets of lornoxicam to achieve biphasic release pattern. A bilayered tablet, consisting of an immediate and controlled release layer, was prepared by direct compression technique. The controlled release effect was achieved by using various hydrophilic natural, semi synthetic and synthetic controlled release polymers such as xanthan gum, hydroxypropyl methylcellulose (HPMC) and polyethylene oxide (PEO) to modulate the release of the drug. The in vitro drug release profiles showed the biphasic release behavior in which the immediate release (IR) layer containing the lornoxicam was released within 15 minutes, whereas the controlled release (CR) layer controlled the drug release for up to 24 h. All the bilayered tablets formulated have followed the zero order release with non-Fickian diffusion controlled release mechanism after the initial burst release. FTIR studies revealed that there was no interaction between the drug and polymers used in the study. Statistical analysis (ANOVA) showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 24 h from optimized formulations was observed. Based on the release kinetic parameters obtained, it can be concluded that xanthan gum polymer was suitable for providing a biphasic release of lornoxicam.

Synthesis and characterization of CaCO 3 –biopolymer hybrid nanoporous microparticles for controlled release of doxorubicin

2014 ◽  
Vol 123 ◽  
pp. 158-169 ◽  
Author(s):  
Valeria E. Bosio ◽  
Maximiliano L. Cacicedo ◽  
Brice Calvignac ◽  
Ignacio León ◽  
Thomas Beuvier ◽  
...  
Keyword(s):  
Controlled Release ◽  
Synthesis And Characterization

Synthesis and characterization of polyelectrolyte complex microparticles for drug release

2012 ◽  
Vol 128 (6) ◽  
pp. 3548-3554 ◽  
Author(s):  
L. Agüero ◽  
J. García ◽  
O. Valdés ◽  
G. Fuentes ◽  
D. Zaldivar ◽  
...  
Keyword(s):  
Drug Release ◽  
Polyelectrolyte Complex ◽  
Synthesis And Characterization

DESIGN AND CHARACTERIZATION OF ALFUZOSIN HCL GASTRORETENTIVE FLOATING MATRIX TABLETS EMPLOYING HPMC K 100M

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (11) ◽  
pp. 71-73
Author(s):  
Ch. Taraka Ramarao ◽  
◽  
J Vijaya Ratna ◽  
R. B. Srinivasa
Keyword(s):  
Drug Release ◽  
Dosage Forms ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Gastric Residence Time ◽  
Drug Release Mechanism ◽  
The Matrix ◽  
Gastro Retentive

The present investigation involves developing gastro retentive drug delivery systems (GFDDS) of alfuzosin HCl using HPMCK100M a is the matrixing agent and floating enhancer. Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and thereby increase the oral bioavailability. From the drug release study, it was concluded that the AFTB4 formula of HPMC K 100 M matrix tablets gives the controlled release up to 12 hours by showing increased release with floating lag time 24 seconds. Non – Fickian diffusion was the drug release mechanism from the matrix tablets formulated employing HPMC K 100 M. The matrix tablets (AFTB4) formulated employing 40 % HPMC K 100 M are best suited to be used for gastro retentive dosage form of alfuzosin HCl. Finally, it can be concluded that good candidates for the preparation of gastro retentive dosage forms due its gastric stability, gastric absorption and better bioavailability.

Synthesis and characterization of cross-linked malonylchitosan microspheres for controlled release of acyclovir

2008 ◽  
Vol 73 (3) ◽  
pp. 490-497 ◽  
Author(s):  
Hellen Karine Stulzer ◽  
Loreana Lacerda ◽  
Monika P. Tagliari ◽  
Marcos A.S. Silva ◽  
Valfredo T. Fávere ◽  
...  
Keyword(s):  
Controlled Release ◽  
Synthesis And Characterization

scholarly journals Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance

2018 ◽  
Author(s):  
Barkat Khan ◽  
Faheem Haider ◽  
Kifayat Shah ◽  
Bushra Uzair ◽  
Kaijian Hou ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Kinetics ◽  
Immediate Release ◽  
Matrix Tablets ◽  
Release Mechanism ◽  
In Vitro Drug Release ◽  
Solubility Study ◽  
Release Data

This study was carried out to formulate and evaluate controlled release (CR) matrix tablets of Acyclovir using combination of hydrophilic and hydrophobic polymers. Acyclovir is a guanine derivative and is its half-life is short hence administered five times a day using immediate release tablets. Six formulations (F1-F6) were developed using Ethocel and Carbopol in equal combinations at drug-polymer (D:P) ratio of 10:5, 10:6, 10:7, 10:8, 10:9 and 10:10. Solubility study was performed using six different solvents. The compatibility studies were carried out using FTIR and DSC. According to USP, Quality Control and dimensional tests (hardness, friability, disintegration and thickness) were executed. In-vitro drug release studies of Acyclovir was carried out in dissolution apparatus using using 0.1 N HCl medium at constant temperature of 37 ± 0.5 ºC. In order to analyze the drug release kinetics, five different mathematical models were applied to the release data. The results showed that there was no incompatibility between drug and polymers. Physical QC tests were found within limits of USP. The release was retarded upto 24 hrs and non-fickian in-vitro drug release mechanism was found. A formulation developed using blend of polymers, showed excellent retention and desired release profiles thus providing absolute control for 24 hrs.

Synthesis and characterization of gibberellin–chitosan conjugate for controlled-release applications

2013 ◽  
Vol 57 ◽  
pp. 213-217 ◽  
Author(s):  
Yao Liu ◽  
Yan Sun ◽  
Shun He ◽  
Yuncong Zhu ◽  
Mingming Ao ◽  
...  
Keyword(s):  
Controlled Release ◽  
Synthesis And Characterization
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