scholarly journals 2,6-Dichloro-4-nitroaniline –loaded Electrospun Cellulose Acetate Fiber Mats and Their Release Characteristics

2011 ◽  
Vol 10 (2) ◽  
pp. 40 ◽  
Author(s):  
Patcharaporn Thitiwongsawet ◽  
Paweena Ouykul ◽  
Akkarin Khaoroppan
Keyword(s):  
Weight Loss ◽  
Cellulose Acetate ◽  
Water Retention ◽  
Spectroscopic Method ◽  
Immersion Method ◽  
Fiber Mats ◽  
Cast Films ◽  
1H Nuclear Magnetic Resonance ◽  
Total Immersion ◽  
Cellulose Acetate Fiber

Mats of cellulose acetate (CA) nanofibers containing 2,6-dichloro-4-nitroaniline (DCNA) were successfully fabricated by electrospinning from the neat CA solution (17% w/v in 2:1 acetone/dimethylacetamide) containing DCNA in various amounts (i.e. 5-15 wt. % based on the weight of CA). The morphological appearance of both the neat and the DCNA-loaded electrospun CA fibers were smooth and the incorporation of DCNA in the neat CA solution did not affect the morphology of the resulting fibers. The average diameters of the neat and the DCNA-loaded electrospun CA fibers ranged between 241-320 nm. The integrity of the as-loaded DCNA in the DCNA-loaded CA fiber mats was intact as verified by the 1H-nuclear magnetic resonance spectroscopic method. The amount of water retention, the amount of weight loss, and release characteristics of the DCNA-loaded CA fiber mats and the DCNA-loaded as-cast films in distilled water at 30°C were studied. The release characteristics were investigated by the total immersion method. The DCNA-loaded CA fiber mats exhibited greater amount of water retention, weight loss, and DCNA released than the DCNA-loaded as-cast films.

Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats

Polymer ◽  
2007 ◽  
Vol 48 (17) ◽  
pp. 5030-5041 ◽  
Author(s):  
Santi Tungprapa ◽  
Ittipol Jangchud ◽  
Pitt Supaphol
Keyword(s):  
Cellulose Acetate ◽  
Fiber Mats ◽  
Cellulose Acetate Fiber

Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance

Polymer ◽  
2007 ◽  
Vol 48 (26) ◽  
pp. 7546-7557 ◽  
Author(s):  
Orawan Suwantong ◽  
Praneet Opanasopit ◽  
Uracha Ruktanonchai ◽  
Pitt Supaphol
Keyword(s):  
Cellulose Acetate ◽  
Fiber Mats ◽  
Cellulose Acetate Fiber ◽  
Release Characteristic

Electrospun Cellulose Acetate Fiber Containing Rubber Extract

2015 ◽  
Vol 1119 ◽  
pp. 329-333 ◽  
Author(s):  
Natthakitta Suwannateep ◽  
Chidchanok Meechaisue ◽  
Hubert Ruch
Keyword(s):  
Cellulose Acetate ◽  
High Surface ◽  
Potential Candidate ◽  
High Porosity ◽  
Fiber Mats ◽  
New Approach ◽  
Surface Areas ◽  
Innovative Products ◽  
Cellulose Acetate Fiber ◽  
First Time

Recent studies on cream of rubber extract (HB) have significantly showed skin improvement results, however, there were color and odor issues. To solve the problems, we successfully produced ultra-fine cellulose acetate (CA) fiber mats (electrospun fibers) containing 1-5 wt% extracts of rubber from Hevea brasilensis without any chemical additions. This new approach has in fact revealed the desired material and biomolecule immobilization. The SEM photographs show the straight and even shaping of the processed HB-CA fibers. The average fiber diameters of the HB-CA fibers ranged between 415 and 585 nm. Moreover, HB-CA solutions containing 1-3% HB extract resulted in a more consistent texture of the fiber mats. This was the first time to produce nanofibers using only rubber extract and cellulose acetate without any other potentially bioactive components involved. This innovation did not only solve the initially addressed color and odor issues, but also provided a new purified material of very small fibers which allows better control of its bioactivity due to the fact that less chemical substances are involved. Its highly interesting characteristics, such as high surface areas to mass ratio, high porosity et al make this result an excellent potential candidate e.g. facial masks, and other innovative products in the field of cosmetics and pharmaceutical industry. Further research is needed and highly promising.

Ciprofloxacin-loaded alginate/poly (vinyl alcohol)/gelatin electrospun nanofiber mats as antibacterial wound dressings

2021 ◽  
pp. 152808372199746
Author(s):  
Tittaya Thairin ◽  
Patcharaporn Wutticharoenmongkol
Keyword(s):  
Weight Loss ◽  
Vinyl Alcohol ◽  
Diffusion Method ◽  
Poly Vinyl Alcohol ◽  
Burst Release ◽  
Electrospun Nanofiber ◽  
Total Immersion ◽  
Water Swelling ◽  
Nanofiber Mats ◽  
And Diffusion

Herein, ciprofloxacin (CIP)-loaded alginate/poly (vinyl alcohol)/gelatin (SPG) (CIP–SPG) nanofiber mats were successfully fabricated by electrospinning. The average fiber diameters of the mats before and after crosslinking were in the range of 190–260 and 385–484 nm, respectively. The chemical integrity of CIP remained intact after encapsulation into the mats. The degree of weight loss and water swelling decreased with an increase in the gelatin content of the electrospun nanofiber mats. A release study was carried out by total immersion and diffusion methods using phosphate buffer as a release medium. Burst release of CIP was observed in case of the total immersion method, while a more sustained release was observed in case of the diffusion method. The maximum amounts of CIP released during total immersion and diffusion were in the range of 70–90% and 72–85%, respectively. For both the total immersion and diffusion methods, the released amounts of CIP decreased and the release slowed down with an increase in the gelatin content; this result is consistent with the weight loss and water swelling values. The Young’s modulus increased, while the tensile strength and strain at break decreased with an increase in the gelatin content. The CIP–SPG nanofiber mats were slightly toxic to L929 mouse fibroblasts as evaluated by indirect cytotoxicity assay. The electrospun CIP–SPG nanofiber mats exhibited excellent antimicrobial activity against Staphylococcus aureus and Escherichia coli. These results reveal that the electrospun CIP–SPG nanofiber mats are potentially promising materials for wound healing applications.

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