In Vivo Proton Spectroscopy of Giant Cell Tumor of the Bone

2008 ◽  
Vol 190 (2) ◽  
pp. W133-W139 ◽  
Author(s):  
Panna Lal Sah ◽  
Raju Sharma ◽  
Harsh Kandpal ◽  
Ashu Seith ◽  
Shishir Rastogi ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Proton Spectroscopy

scholarly journals A short-term in vivo model for giant cell tumor of bone

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Maurice Balke ◽  
Anna Neumann ◽  
Károly Szuhai ◽  
Konstantin Agelopoulos ◽  
Christian August ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
In Vivo Model ◽  
Short Term

scholarly journals Expressional Analysis of GFP-Tagged Cells in an In Vivo Mouse Model of Giant Cell Tumor of Bone

2013 ◽  
Vol 7 (1) ◽  
pp. 109-113 ◽  
Author(s):  
S Singh ◽  
M Singh ◽  
I Mak ◽  
M Ghert
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Green Fluorescence Protein ◽  
Cell Tumor ◽  
Green Fluorescence ◽  
Continuous Growth ◽  
Stromal Component ◽  
Fluorescence Protein

Giant cell tumor of bone in a neoplastic stromal cell which survives for multiple passages in primary cell culture with a stable phenotype. In the pathological environment of GCT, the neoplastic nature of the mesenchymal stromal component drives local hematopoietic precursors to undergo fusion and form multinucleated osteoclast like giant cells. There is currently very limited knowledge about the pathogenesis of GCT due to the lack of suitable in vivo models for this tumor. Here we report stable gene transfer of Green fluorescence protein (GFP) in GCT stromal cells. In the present study, we have used GCT stromal cells that stably express enhanced green fluorescence protein (GFP) that are used in a new in vivo culture model. Our results show the utility of the GFP tagged cell lines that stably express GFP signals up to 52 weeks of continuous growth. The in vivo model described herein can serve as an excellent system for in vivo therapeutic and mechanistic evaluation of existing and novel targets for GCT.

MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone

2017 ◽  
Vol 409 ◽  
pp. 49-55 ◽  
Author(s):  
Ingrid Herr ◽  
Heiner Sähr ◽  
Zhefu Zhao ◽  
Libo Yin ◽  
Georg Omlor ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tumor Suppressors ◽  
Cell Tumor

scholarly journals Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Yunfei He ◽  
Dongdong Cheng ◽  
Cheng Lian ◽  
Yingjie Liu ◽  
Wenqian Luo ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Osteoclast Differentiation ◽  
Xenograft Model ◽  
Bone Destruction ◽  
Underlying Mechanism ◽  
Cell Tumor

AbstractGiant cell tumor of bone (GCTB) is an aggressive osteolytic bone tumor characterized by the within-tumor presence of osteoclast-like multinucleated giant cells (MGCs), which are induced by the neoplastic stromal cells and lead to extensive bone destruction. However, the underlying mechanism of the pathological process of osteoclastogenesis in GCTB is poorly understood. Here we show that the proteoglycan Serglycin (SRGN) secreted by neoplastic stromal cells plays a crucial role in the formation of MGCs and tumorigenesis in GCTB. Upregulated SRGN expression and secretion are observed in GCTB tumor cells and patients. Stromal-derived SRGN promotes osteoclast differentiation from monocytes. SRGN knockdown in stromal cells inhibits tumor growth and bone destruction in a patient-derived orthotopic xenograft model of mice. Mechanistically SRGN interacts with CD44 on the cell surface of monocytes and thus activates focal adhesion kinase (FAK), leading to osteoclast differentiation. Importantly, blocking CD44 with a neutralizing antibody reduces the number of MGCs and suppresses tumorigenesis in vivo. Overall, our data reveal a mechanism of MGC induction in GCTB and support CD44-targeting approaches for GCTB treatment.

Bilateral Mirror-Symmetrical Giant Cell Tumor of the Tendon Sheath in the Foot and Ankle: A Case Report

2021 ◽  
Vol 60 (1) ◽  
pp. 163-166
Author(s):  
Naji S. Madi ◽  
Said Saghieh ◽  
Ahmad Salah Naja ◽  
Rachid K. Haidar
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Foot And Ankle

Giant cell tumor of bone: A single institutional three years study

2019 ◽  
Vol 12 (1) ◽  
pp. 3-135
Author(s):  
Amisha Gami ◽  
◽  
Brinda S. Chandibhamar ◽  
Ashini Shah ◽  
Jahnavi Gandhi ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor
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