scholarly journals TWO-DIMENSIONAL NUMERICAL MODEL FOR SOLUTE TRANSPORT IN VARIABLY SATURATED POROUS MEDIA

1993 ◽  
Vol 37 ◽  
pp. 367-372
Author(s):  
Le Dinh HONG ◽  
Juichiro AKIYAMA ◽  
Masaru URA
Keyword(s):  
Porous Media ◽  
Numerical Model ◽  
Solute Transport ◽  
Saturated Porous Media ◽  
Two Dimensional

Experimental investigation of solute transport in variably saturated porous media using x-ray computed tomography

2021 ◽  
Vol 33 (7) ◽  
pp. 076610
Author(s):  
Chunwei Zhang ◽  
Yun She ◽  
Yingxue Hu ◽  
Zijing Li ◽  
Weicen Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Experimental Investigation ◽  
Porous Media ◽  
Solute Transport ◽  
Saturated Porous Media ◽  
X Ray ◽  
X Ray Computed

Numerical Simulation of Insulin Depot Formation and Absorption in Subcutaneous Tissue Modeled as a Homogeneous Anisotropic Porous Media

2021 ◽  
Author(s):  
Michael Zedelmair ◽  
Abhijit Mukherjee
Keyword(s):  
Porous Media ◽  
Numerical Model ◽  
Insulin Pump ◽  
Subcutaneous Tissue ◽  
Saturated Porous Media ◽  
Anisotropic Porous Media ◽  
Effective Option ◽  
Computational Fluid Dynamics Cfd ◽  
Experimental Findings ◽  
Subcutaneous Adipose

Abstract In this study, a numerical model of the insulin depot formation and absorption in the subcutaneous adipose tissue is developed using the commercial Computational Fluid Dynamics (CFD) software. A better understanding of these mechanisms can be helpful in the development of new devices and cannula geometries as well as predicting the concentration of insulin in the blood. The injection method considered in this simulation is by the use of an insulin pump using a rapid acting U100 insulin analogue. The depot formation is analyzed running Bolus injections ranging from 5-15 units of insulin corresponding to 50-150µl. The insulin is injected into the subcutaneous tissue in the abdominal region. The tissue is modeled as a fluid saturated porous media. An anisotropic approach to define the tissue permeability is studied by varying the value of the porosity in parallel and perpendicular direction having an impact on the viscous resistance to the flow. Following recent experimental findings this configuration results in a disk shaped insulin depot. To be able to run the simulation over longer timeframes the depot formation model has been extended implementing the process of absorption of insulin from the depot. The developed model is then used to analyze the formation of the insulin depot in the tissue when using different flow rates and cannula geometries. The numerical model is an effective option to evaluate new cannula designs prior to the manufacturing and testing of prototypes, which are rather time consuming and expensive.

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