Random road profiles and wheelbase filtering, both of which strongly affect vehicle dynamic performance characteristics, have been explored in many studies. These studies invariably focused on either characterizing road roughness or vehicle dynamics considering wheelbase filtering effect. No effort, however, has been attempted to characterize road roughness profiles upon considering vehicle wheelbase filtering effect, and then to investigate their combined roles on vehicle dynamic responses. In this study, characteristics of different random road profiles are investigated upon considering wheelbase filtering effect. Two vehicle models, including quarter-car and pitch-plane models, are then employed to analyze the combined influence of random road roughness and wheelbase filtering on vehicle dynamics. The simulation results reveal the significant difference between the characteristics of random road profiles with and without wheelbase filtering effect. The results further demonstrate that wheelbase filtering has a positive effect on vehicle vertical ride, with a negligible or small compromise on suspension travel and dynamic tire deflection.