scholarly journals Simulations of Recovery Times Following Nondepolarizing Neuromuscular Blockade Produced by Steady-state Infusions. Vecuronium, Pancuronium and Rocuronium.

1999 ◽  
Vol 19 (10) ◽  
pp. 601-608 ◽  
Author(s):  
Choku YAJIMA ◽  
Shozou TSUDAKA ◽  
Osamu NAGATA ◽  
Megumi TAGAMI ◽  
Kazuo HANAOKA
Keyword(s):  
Steady State ◽  
Neuromuscular Blockade ◽  
Recovery Times ◽  
Nondepolarizing Neuromuscular Blockade

LOCALIZED HYPOTHERMIA POTENTIATES NONDEPOLARIZING NEUROMUSCULAR BLOCKADE

1988 ◽  
Vol 69 (3A) ◽  
pp. A294-A294 ◽  
Author(s):  
C W Hanson ◽  
M L Young ◽  
M J Bloom ◽  
S Muravchick ◽  
J Savino
Keyword(s):  
Neuromuscular Blockade ◽  
Nondepolarizing Neuromuscular Blockade

A880 DOUBLE BURST STIMULATION ASSESSMENT OF NONDEPOLARIZING NEUROMUSCULAR BLOCKADE

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA ◽  
Author(s):  
E. P. Anderson ◽  
K. A. Jones ◽  
E. P. Stensrud ◽  
R. L. Lennon
Keyword(s):  
Neuromuscular Blockade ◽  
Burst Stimulation ◽  
Double Burst Stimulation ◽  
Nondepolarizing Neuromuscular Blockade

Spontaneous Recovery From Nondepolarizing Neuromuscular Blockade

1977 ◽  
Vol 56 (1) ◽  
pp. 55???58 ◽  
Author(s):  
JEFFRY B. BRAND ◽  
DAVID J. CULLEN ◽  
NORMAN E. WILSON ◽  
HASSAN H. ALI
Keyword(s):  
Neuromuscular Blockade ◽  
Spontaneous Recovery ◽  
Nondepolarizing Neuromuscular Blockade

A879 DOUBLE BURST STIMULATION ASSESSMENT OF NONDEPOLARIZING NEUROMUSCULAR BLOCKADE

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
K. A. Jones ◽  
R. L. Lennon ◽  
P. E. Stensrud ◽  
J. G. Weber ◽  
M. J. Joyner
Keyword(s):  
Neuromuscular Blockade ◽  
Burst Stimulation ◽  
Double Burst Stimulation ◽  
Nondepolarizing Neuromuscular Blockade

An Evaluation of Continuous Infusion Rocuronium for Sustained Neuromuscular Blockade in Critically Ill Adults

2020 ◽  
pp. 106002802096673
Author(s):  
Lara M. Groetzinger ◽  
Aaron T. Hutchins ◽  
Ryan M. Rivosecchi
Keyword(s):  
Continuous Infusion ◽  
Neuromuscular Blockade ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blocking Agent ◽  
Multiple Organ ◽  
Neuromuscular Blocking ◽  
Icu Patients ◽  
Recovery Times ◽  
Critically Ill Adults

Background: Recent medication shortages of the neuromuscular blocking agent (NMBA) cisatracurium have forced the prescribing of aminosteroidal agents such as rocuronium. There are limited data on the use and dosing of continuous infusion (CI) rocuronium in critically ill patients outside of the operating room. Objective: We sought to describe the use of CI rocuronium for sustained neuromuscular blockade in intensive care unit (ICU) patients by characterizing the dosing, utilization, and safety profile in patients with multiple organ failure (MOF) and non-MOF. Methods: This was a retrospective review of patients in mixed ICUs from 2 tertiary medical centers who received CI rocuronium between January 2018 and July 2019. Results: A total of 46 unique rocuronium infusions were utilized for 40 patients during the evaluation period. Of these, 37% had MOF, and 41% had at least 1 organ fail during the rocuronium infusion. The median starting and maximum dose was 8 µg/kg/min. Overall, 64% of train of 4 (TOF) measurements were a TOF 0 (T0) or TOF 1 (T1), with a higher percentage of T0 or T1 in the MOF group compared with the non-MOF group (75% vs 50%). The median time to recovery was more than twice as long for the MOF compared with the non-MOF group (10 vs 4.6 hours). ICU-acquired weakness was diagnosed in 27% of survivors. Conclusion and Relevance: In ICU patients with MOF, continuous rocuronium infusions were associated with deep levels of paralysis and prolonged recovery times. If neuromuscular blockade is required for critically ill patients, alternative strategies could be considered.

Sign in / Sign up

Export Citation Format

Share Document