Evaluation of the quality of antibody drugs and cell therapy products using lectin microarray

2018 ◽  
Vol 62 (1) ◽  
pp. 27-30
Author(s):  
Hiroaki Tateno
Keyword(s):  
Cell Therapy ◽  
Lectin Microarray

scholarly journals Cell Therapy in Patients with Critical Limb Ischemia

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Rita Compagna ◽  
Bruno Amato ◽  
Salvatore Massa ◽  
Maurizio Amato ◽  
Raffaele Grande ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Tissue Loss ◽  
Systematic Analysis ◽  
Peripheral Arterial Obstructive Disease ◽  
Peripheral Arterial ◽  
Cellular Components

Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

scholarly journals Conformational stability as a quality attribute for the cell therapy raw material human serum albumin

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15332-15339
Author(s):  
Evelien Wynendaele ◽  
Gamaliel Junren Ma ◽  
Xiaolong Xu ◽  
Nam-Joon Cho ◽  
Bart De Spiegeleer
Keyword(s):  
Human Serum Albumin ◽  
Cell Therapy ◽  
Serum Albumin ◽  
Human Serum ◽  
Conformational Stability ◽  
Raw Material ◽  
Quality Attribute ◽  
Global Measure ◽  
Pharmaceutical Quality

An overall attribute for the consistency in pharmaceutical quality of human serum albumin encompasses a global measure of conformational stability, as measured by CD, DLS, QCM-D or LSPR.

Application Effect Analysis of Nursing Intervention in Stem Cell Therapy for Stroke Patients

2021 ◽  
Vol 7 (4) ◽  
pp. 392-399
Author(s):  
Jing Zhao ◽  
Lili Fu ◽  
Juan Zhu ◽  
Yan Liu ◽  
Xiaoqian Sun
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Daily Living ◽  
Nursing Intervention ◽  
Control Group ◽  
Observation Group ◽  
Stroke Patients

To study and analyze the actual clinical effect of nursing intervention in stem cell therapy for stroke patients. A total of 9 stroke patients treated with stem cell therapy in our hospital from September 2018 to September 2019 were selected as the research and analysis objects. All patients were divided into observation group 5 stroke patients and control group 4 stroke patients by random number method. Both groups of patients were treated with stem cell therapy. Patients in the control group were treated with conventional nursing methods, and patients in the observation group were treated with nursing intervention methods. The treatment compliance, psychological status, quality of life and daily living ability before and after intervention were compared between the two groups. There were no significant differences in exercise training, disease monitoring and compliance with regular life between the two groups before intervention (P > 0.05), and the patients in observation group were significantly better than those in control group after intervention (P < 0.05), with significant differences. There was no significant difference in anxiety and depression scores between the two groups before intervention (P > 0.05), and after intervention, the patients in the observation group were significantly lower than those in the control group (P < 0.05), and the difference was statistically significant. There was no significant difference in quality of life and ability of daily living between the two groups before intervention (P > 0.05), and the patients in the observation group were significantly better than those in the control group after intervention (P < 0.05), the difference was statistically significant. The application of nursing intervention in stem cell therapy for stroke patients has a significant effect, which significantly improves the patient's compliance with the treatment, alleviates the negative emotions of patients, improves the psychological status of patients, improves the quality of life and daily living ability of patients, and is worthy of popularization and application in clinical nursing.

scholarly journals Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research

2018 ◽  
Vol 27 (12) ◽  
pp. 1723-1730 ◽  
Author(s):  
Haiqing Zheng ◽  
Bin Zhang ◽  
Pratik Y. Chhatbar ◽  
Yi Dong ◽  
Ali Alawieh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Animal Studies ◽  
Current Evidence ◽  
Human Trials

Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-clinical studies and clinical trials between 2008 and 2017 using the public databases PubMed and Ovid Medline, and the clinical trial registry ( www.clinicaltrials.gov ). A total of 78 pre-clinical studies and eight clinical studies were identified. While majority of the pre-clinical and clinical studies demonstrated statistically significant effects, the clinical significance of these findings was still unclear. Effect sizes could not be measured mainly due to reporting issues in pre-clinical studies, thus limiting our ability to compare results across studies quantitatively. The overall quality of both pre-clinical and clinical studies was sub-optimal. By conducting a systematic review of both pre-clinical and clinical studies on MSCs therapy in stroke, we assessed the quality of current evidence and identified several issues and gaps in translating animal studies to human trials. Addressing these issues and incorporating changes into future animal studies and human trials may lead to better success of stem cells-based therapeutics in the near future.

scholarly journals An update review of stem cell applications in burns and wound care

2012 ◽  
Vol 45 (02) ◽  
pp. 229-236 ◽  
Author(s):  
Lin Huang ◽  
Andrew Burd
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Medical Technology ◽  
Wound Care ◽  
Therapeutic Strategies ◽  
Wound Management

ABSTRACTThe ultimate goal of the treatment of cutaneous burns and wounds is to restore the damaged skin both structurally and functionally to its original state. Recent research advances have shown the great potential of stem cells in improving the rate and quality of wound healing and regenerating the skin and its appendages. Stem cell-based therapeutic strategies offer new prospects in the medical technology for burns and wounds care. This review seeks to give an updated overview of the applications of stem cell therapy in burns and wound management since our previous review of the "stem cell strategies in burns care".

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