scholarly journals Robotic Versus Open Renal Transplantation in Obese Patients: Protocol for a Cost-Benefit Markov Model Analysis

2018 ◽  
Vol 7 (3) ◽  
pp. e74
Author(s):  
Michele Molinari ◽  
Chethan Puttarajappa ◽  
Martin Wijkstrom ◽  
Armando Ganoza ◽  
Roberto Lopez ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Markov Model ◽  
Cost Benefit ◽  
Model Analysis ◽  
Obese Patients

scholarly journals Robotic Versus Open Renal Transplantation in Obese Patients: Protocol for a Cost-Benefit Markov Model Analysis (Preprint)

2017 ◽  
Author(s):  
Michele Molinari ◽  
Chethan Puttarajappa ◽  
Martin Wijkstrom ◽  
Armando Ganoza ◽  
Roberto Lopez ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Renal Transplantation ◽  
Renal Replacement Therapy ◽  
Renal Transplant ◽  
Markov Model ◽  
Replacement Therapy ◽  
Controlled Trial ◽  
Cost Benefit ◽  
Obese Patients ◽  
Robotic Assisted

BACKGROUND Recent studies have reported a significant decrease in wound problems and hospital stay in obese patients undergoing renal transplantation by robotic-assisted minimally invasive techniques with no difference in graft function. OBJECTIVE Due to the lack of cost-benefit studies on the use of robotic-assisted renal transplantation versus open surgical procedure, the primary aim of our study is to develop a Markov model to analyze the cost-benefit of robotic surgery versus open traditional surgery in obese patients in need of a renal transplant. METHODS Electronic searches will be conducted to identify studies comparing open renal transplantation versus robotic-assisted renal transplantation. Costs associated with the two surgical techniques will incorporate the expenses of the resources used for the operations. A decision analysis model will be developed to simulate a randomized controlled trial comparing three interventional arms: (1) continuation of renal replacement therapy for patients who are considered non-suitable candidates for renal transplantation due to obesity, (2) transplant recipients undergoing open transplant surgery, and (3) transplant patients undergoing robotic-assisted renal transplantation. TreeAge Pro 2017 R1 TreeAge Software, Williamstown, MA, USA) will be used to create a Markov model and microsimulation will be used to compare costs and benefits for the two competing surgical interventions. RESULTS The model will simulate a randomized controlled trial of adult obese patients affected by end-stage renal disease undergoing renal transplantation. The absorbing state of the model will be patients' death from any cause. By choosing death as the absorbing state, we will be able simulate the population of renal transplant recipients from the day of their randomization to transplant surgery or continuation on renal replacement therapy to their death and perform sensitivity analysis around patients' age at the time of randomization to determine if age is a critical variable for cost-benefit analysis or cost-effectiveness analysis comparing renal replacement therapy, robotic-assisted surgery or open renal transplant surgery. After running the model, one of the three competing strategies will result as the most cost-beneficial or cost-effective under common circumstances. To assess the robustness of the results of the model, a multivariable probabilistic sensitivity analysis will be performed by modifying the mean values and confidence intervals of key parameters with the main intent of assessing if the winning strategy is sensitive to rigorous and plausible variations of those values. CONCLUSIONS After running the model, one of the three competing strategies will result as the most cost-beneficial or cost-effective under common circumstances. To assess the robustness of the results of the model, a multivariable probabilistic sensitivity analysis will be performed by modifying the mean values and confidence intervals of key parameters with the main intent of assessing if the winning strategy is sensitive to rigorous and plausible variations of those values.

Evaluating the cost-effectiveness of universal hepatitis B virus vaccination in Iran: a Markov model analysis

2021 ◽  
pp. 1-9
Author(s):  
Ali Mohammad Mokhtari ◽  
Mohsen Barouni ◽  
Mohsen Moghadami ◽  
Jafar Hassanzadeh ◽  
Rebecca Susan Dewey ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Markov Model ◽  
Model Analysis ◽  
Virus Vaccination ◽  
B Virus ◽  
The Cost

scholarly journals A comparative hidden Markov model analysis pipeline identifies proteins characteristic of cereal-infecting fungi

BMC Genomics ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 807 ◽  
Author(s):  
Jana Sperschneider ◽  
Donald M Gardiner ◽  
Jennifer M Taylor ◽  
James K Hane ◽  
Karam B Singh ◽  
...  
Keyword(s):  
Markov Model ◽  
Hidden Markov Model ◽  
Hidden Markov ◽  
Model Analysis ◽  
Analysis Pipeline

Photon-by-Photon Hidden Markov Model Analysis for Microsecond Single-Molecule FRET Kinetics

2016 ◽  
Vol 120 (51) ◽  
pp. 13065-13075 ◽  
Author(s):  
Menahem Pirchi ◽  
Roman Tsukanov ◽  
Rashid Khamis ◽  
Toma E. Tomov ◽  
Yaron Berger ◽  
...  
Keyword(s):  
Markov Model ◽  
Hidden Markov Model ◽  
Single Molecule ◽  
Hidden Markov ◽  
Model Analysis ◽  
Single Molecule Fret

scholarly journals Renal transplantation in obese patients

2013 ◽  
Vol 24 (4) ◽  
pp. 795 ◽  
Author(s):  
Alp Gurkan ◽  
Serdar Kacar ◽  
Can Varilsuha ◽  
Volkan Turunc ◽  
Hamad Dheir ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Obese Patients

scholarly journals Outcome of Anticoagulant Therapy Following Bariatric Surgery

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Yousef ◽  
A F Mohamed ◽  
B H Elshayeb ◽  
G M Abdelmalak
Keyword(s):  
Bariatric Surgery ◽  
Effective Means ◽  
Cost Benefit ◽  
Morbidly Obese ◽  
Laparoscopic Bariatric Surgery ◽  
Obese Patients ◽  
University Hospitals ◽  
Coagulation Therapy ◽  
Anticoagulant Drugs ◽  
Significant Difference

Abstract Background Bariatric surgery remains the most effective means of treating severe obesity. The number of severely obese patients is increasing and, consequently, more people are seeking bariatric surgery. Aim of the Work The Aim of This Study is to Outcome of Anticoagulant during Bariatric Surgery and Relation of Bariatric Surgery to Coagulopathy Disease. Patients and Methods This prospective study was conducted on 50 morbidly obese patients admitted to Hospital (Ahmed Maher Teaching Hospital and Ain Shams University Hospitals), for a primary one-stage laparoscopic bariatric surgery procedure over a 6-month period. The study is performed on 50 Patients, Who met all Inclusion criteria and none of Exclusion criteria. Results The study revealed no statistically significant difference between Enoxaparin and Rivaroxaban according to outcome of anti-coagulation therapy following bariatric surgery. Conclusion a high protective value of Chemical Thromboprophylaxis combined to Mechanical Thromboprophylaxis in preventing DVT safely. New Oral Anticoagulant drugs showed equal and may be superimposed the other traditional anticoagulant, but it needs more studies regarding its prophylactic dose, number of patient and its cost benefit in comparison with other Anticoagulant drugs were used in our study or other studies we mentioned above.

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