scholarly journals Epidemiology of Surgical Site Infections With Staphylococcus aureus in Europe: Protocol for a Retrospective, Multicenter Study

2018 ◽  
Vol 7 (3) ◽  
pp. e63 ◽  
Author(s):  
Sibylle C Mellinghoff ◽  
Jörg Janne Vehreschild ◽  
Blasius J Liss ◽  
Oliver A Cornely
Keyword(s):  
Staphylococcus Aureus ◽  
Multicenter Study ◽  
Surgical Site Infections ◽  
Retrospective Multicenter Study

scholarly journals Implant Removal in the Management of Prosthetic Joint Infection by Staphylococcus aureus: Outcome and Predictors of Failure in a Large Retrospective Multicenter Study

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 118
Author(s):  
Joan Gómez-Junyent ◽  
Jaime Lora-Tamayo ◽  
Josu Baraia-Etxaburu ◽  
Mar Sánchez-Somolinos ◽  
Jose Antonio Iribarren ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Multicenter Study ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Implant Removal ◽  
Local Failure ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Prosthetic Joint ◽  
Retrospective Multicenter Study

Objectives: To compare the characteristics and outcomes of cases with acute prosthetic joint infection (PJI; early post-surgical or hematogenous) by Staphylococcus aureus managed with implant removal (IRm) or debridement and retention (DAIR). To analyze the outcomes of all cases managed with IRm (initially or after DAIR failure). Methods: Retrospective, multicenter, cohort study of PJI by S. aureus (2003–2010). Overall failure included mortality within 60 days since surgery and local failure due to staphylococcal persistence/relapse. Results: 499 cases, 338 initially managed with DAIR, 161 with IRm. Mortality was higher in acute PJI managed initially with IRm compared to DAIR, but not associated with the surgical procedure, after propensity score matching. Underlying conditions, hemiarthroplasty, and methicillin-resistant S. aureus were risk factors for mortality. Finally, 249 cases underwent IRm (88 after DAIR failure); overall failure was 15.6%. Local failure (9.3%) was slightly higher in cases with several comorbidities, but independent of previous DAIR, type of IRm, and rifampin treatment. Conclusions: In a large multicenter study of S. aureus PJI managed with IRm, failure was low, but mortality significant, especially in cases with acute PJI and underlying conditions, but not associated with the IRm itself. Rifampin efficacy was limited in this setting.

scholarly journals Retrospective Multicenter Study on Risk Factors for Surgical Site Infections after Appendectomy for Acute Appendicitis

2016 ◽  
Vol 34 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Louis J.X. Giesen ◽  
Anne Loes van den Boom ◽  
Charles C. van Rossem ◽  
P.T. den Hoed ◽  
Bas P.L. Wijnhoven
Keyword(s):  
Risk Factors ◽  
Acute Appendicitis ◽  
Multicenter Study ◽  
Surgical Site Infections ◽  
Retrospective Multicenter Study

Antimicrobial Resistance Nosocomial Strains of Enterobacter spp. in Ukrainian surgical Hospitals: results of multicenter study

2018 ◽  
Vol 2 (4) ◽  
pp. 39-45
Author(s):  
A.G. Salmanov ◽  
O.M. Verner
Keyword(s):  
Antimicrobial Resistance ◽  
Multicenter Study ◽  
Antimicrobial Susceptibility ◽  
National Level ◽  
Surgical Site Infections ◽  
Hospital Record ◽  
Antimicrobial Susceptibility Test ◽  
Local Data ◽  
Epidemiologic Surveillance ◽  
Medical Institutions

Objective. To determine activity of antimicrobials against Enterobacter spp. isolated from patients hospitalized to surgical departments in different Ukrainian hospitals. Materials and methods. A total of 3991 Enterobacter spp. isolated from patients with surgical site infections in 24 surgical hospitals in 17 Ukrainian regions. The identification and antimicrobial susceptibility of Enterobacter spp. were determined, using automated microbiology analyzer. Some antimicrobial susceptibility test used Kirby - Bauer antibiotic testing. Interpretative criteria were those suggested by the Clinical and Laboratory Standards Institute (CLSI). Results. The most potent antimicrobials were imipenem, meropenem, cefixime and amikacinum. The high rates of resistance were found to penicillin (46,2%), ampicillin/sulbactam (42,9%), gentamicin (40,4%), ceftazidime (39,4%), ampicillin (38,2%), and cefuroxime (36,3%). Conclusions. (1) Resistance of nosocomial strains of Enterobacter spp. at in patient medical institutions, that are subject to research, is a serious therapeutic and epidemiologic issue. Imipenem, meropenem, cefixime and amikacinum have been the most active to nosocomial strains of Enterobacter spp. (2) Taking into account resent changes and resistance levels of nosocomial strains of Enterobacter spp., which take place in various regions, constant monitoring over resistance to antimicrobials at every in patient medical institution is required. Also, hospital record sheets of antibiotics should be elaborated based upon the local data received. (3) Antibiotics utilization policy in each surgical in patient institution should be determined based in accordance with the local data on resistance to antimicrobials. (4) System of epidemiologic surveillance over antimicrobial resistance should be established on the local, regional, and national level.

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