sorry I want to withdraw the manuscript for some personal reason. (Preprint)

2021 ◽  
Author(s):  
F X
Keyword(s):  
Personal Reason

UNSTRUCTURED sorry I want to withdraw the manuscript for some personal reason.

The Operator's View

1960 ◽  
Vol 64 (594) ◽  
pp. 335-339
Author(s):  
J. W. G. James
Keyword(s):  
Flight Safety ◽  
Small Plaque ◽  
Personal Reason ◽  
The Many

It is singularly appropriate that Mr. Walter Tye should be in the Chair today, not only by reason of his membership of the Air Registration Board, that Cerberus which watches so efficiently over so many aspects of safety in the air, but also for a more personal reason. He recently received the “ Aviation Week “ Award for distinguished service in achieving safer utilisation of aircraft, and I should like to take this semi-public opportunity of adding my congratulations to the many which he has received.In many of the offices of my airline one finds displayed a small plaque. On it appears, among other words, the legend “Safety is no Accident.” Although I am no great believer in the power of an oft-repeated formula to achieve miracles, I do believe that these words hold within them much of my flight safety philosophy.

Darwall on Action and the Idea of a Second-Personal Reason

2014 ◽  
Vol 42 (1) ◽  
pp. 243-270
Author(s):  
Fabian Börchers ◽  
Keyword(s):  
Personal Reason

A dose escalation study of nimotuzumab plus irinotecan as second-line treatment in metastatic colorectal cancer with wild-type K-ras.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14122-e14122 ◽  
Author(s):  
Jun Zhou ◽  
Lin Shen ◽  
Jing Gao
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Skin Rash ◽  
Maximum Tolerated Dose ◽  
Chinese Patients ◽  
Line Treatment ◽  
Second Line ◽  
End Points ◽  
Personal Reason ◽  
Grade 3

e14122 Background: Nimotuzumab is a humanized monoclonal antibody of EGFR. We assessed the safety/tolerability and the efficacy of nimotuzumab combined with Irinotecan as the second-line treatment in Chinese patients with metastatic colorectal cancer (mCRC). Methods: Patients with mCRC refractory to oxaliplatin, K-ras WT, signed informed consent, target lesion(s), performance status (PS) ≤2, adequate organ functions, were eligible for this open-labelled, single-armed trial (NCT00972465). Irinotecan was given as 180mg/m2 d1, Q2w until progression or AEs or maximum 6 cycles. Nimotzumab was given as 200, 400, 600 or 800mg weekly until progression or AEs. The primary end points were objective response rate and toxicity. The second end points are PFS and OS. Results: A total of 31 patients (M/F = 22/9; median age 55; range 29-77) have been enrolled from July 2009 to Nov 2011. 4/11/12/4 patients received nimotuzumab as the dose of 200/400/600/800mg respectively. Most common grade 3/4 toxicity are leukopenia (14.8%,) and neutrocytopenia 18.5%). For all the patients, no grade 3/4 toxicity relating with Nimotuzumab was observed. 2 and 3 patients developed skin rash (grade 1) in 400 and 600mg arm respectively. 2 patients developed skin rash grade 2 in 600/800mg arm. The maximum tolerated dose has not yet been reached. Three patients (400/600mg: 2/1) quitted the trial because of personal reason. In 600mg arm, PR was 33.3% (4/12), SD was 25% (3/12); in 400mg arm, PR was 9.l%(1/11), SD was 36.4%(4/11); in 200mg arm, SD was 50%(2/4), PD was 50% (2/4); in 800mg arm, PR was 25%(1/4), PD was 75%(3/4). The follow-up of overall survival is ongoing. Conclusions: Addition of Nimotuzumab with 600mg weekly plus Irinotecan is safe and first data suggest a promising activity. The maximum tolerated dose of Nimotuzumab has not been reached yet.

scholarly journals SELF-CARE MANAGEMENT AMONG ELDERLY PATIENTS WITH HYPERTENSION AND POOR ADHERENCE TO TREATMENT, LIVING IN RURAL THAILAND: A QUALITATIVE STUDY

2018 ◽  
Vol 8 (2) ◽  
pp. 84-89
Author(s):  
Nanthakan Sungsuman Woodham ◽  
Surasak Taneepanichskul ◽  
Ratana Somrongthong ◽  
Nanta Auamkul
Keyword(s):  
Blood Pressure ◽  
Health Problem ◽  
The Elderly ◽  
Drug Regimen ◽  
Poor Adherence ◽  
Community Research ◽  
Personal Reason ◽  
High Sodium ◽  
Negative Beliefs ◽  
Negative Belief

Background: Hypertension is a common health problem among the elderly. Approximately 50% have poor adherence to their prescribed medication, which leads to uncontrolled blood pressure. This study was aimed to understand causes of poor adherence and gain knowledge of patient's self-management in their home. Methods: In-depth interviews were conducted. Elderly hypertension patients with poor adherence to antihypertension medication and uncontrol blood pressure, between the ages of 60-79 were purposively selected to participate in this study. Home visits, including observation of patient's behavior in their home, were conducted. Content analysis was performed. Results: A total of thirty respondents were interviewed of which 17 were female and 13 were male. All understood that hypertension is a chronic health problem but most of them were unaware that nonadherence to their hypertension medication treatment would lead to negative consequence to their health. Most respondents had negative beliefs toward hypertension treatment. The reasons for poor adherence are: 1) personal beliefs or habits, which include forgetfulness and negative belief that the medication will not control blood pressure; 2) side effects of medication and 3) negative perceptions influenced by the community. Research results showed that most participants were not taking their prescribed dosage. Additionally, expired medication was commonly found in their medication inventory. High sodium diets and no regular exercise was commonly reported. Conclusion: Patients understood that hypertension is a lifelong condition but unaware of consequence of poor adherence. Personal reason and negative belief as well as wrong belief influenced by community. Forgetfulness and manage dosage of medication should be addressed when designing a strategy to improve medical adherence. Education on controlling hypertension and treatments should be addressed and incorporated into a holistic strategy to improve adherence to the patient's drug regimen.

The Progress of European Air Transport 1946–1961 with Particular Reference to B.E.A.

1962 ◽  
Vol 66 (615) ◽  
pp. 141-162 ◽  
Author(s):  
Keyword(s):  
Air Transport ◽  
Revolutionary Change ◽  
Personal Reason ◽  
Short Space ◽  
British Commonwealth ◽  
Post War

I count it a great honour to have been asked by the Royal Aeronautical Society to deliver the Seventeenth British Commonwealth Lecture. Reading down the list of previous performers in this rôle one feels that it is indeed an election to a very select company. I have chosen as my subject for this lecture the post-war progress of air transport in Europe. The title may sound rather pedestrian, but I have two main reasons for choosing this theme. First there is the personal reason. I have been intimately associated with the development of air transport in Europe during the post-war period and I am very pleased to have an opportunity to set down a record of the developments which have taken place during those years. Moreover, my associations with European air transport go back to its very beginnings, as pilot of one of Europe’s—and the world’s—first scheduled air services in 1919. The second reason is broader. I welcome an opportunity to review the post-war progress of air transport in Europe because I think that this will show what a revolutionary change the industry has undergone within the relatively short space of fifteen years.

scholarly journals Propaganda and Artificial Glory

2016 ◽  
Vol 2 (1) ◽  
pp. 19-28
Author(s):  
Joshua A Morrow
Keyword(s):  
Careful Analysis ◽  
The State ◽  
Primary Sources ◽  
Spanish American ◽  
Demographic Information ◽  
Major City ◽  
Spanish American War ◽  
Personal Reason ◽  
Secondary Sources ◽  
Personal Stake

This project involves the analysis of both primary and secondary sources to investigate what caused men from three towns in Indiana to volunteer to fight in the Spanish-American War, a conflict that they had no personal reason to join. The predominantly-used primary sources were newspapers from the three towns in Indiana and speeches by politicians. These three towns were selected after careful analysis of demographic information including population and number of volunteers in the Spanish-American War from every major city in the state. To further expand on these ideas, political leanings and occupations were taken into account. Upon completing this study, it was discovered that both the rhetoric of pro-imperial politicians, the propaganda that filled the newspapers of the time, and the creation of the concept of glory and the valor that could be won through combat had an effect on the men’s decision to register for a conflict in which the soldiers had no personal stake. 

Dead Tilt: Playing for Keeps at “The Blue Hotel,” the Prize and the Price

Janus Head ◽  
2015 ◽  
Vol 14 (2) ◽  
pp. 135-158
Author(s):  
Anthony Splendora ◽  
Keyword(s):  
Short Story ◽  
Current Theory ◽  
Stephen Crane ◽  
Personal Reason ◽  
A Site

Stephen Crane had not advanced beyond his teenage years before twelve of the sixteen original members of his immediate family had died, and by his early twenties he was becoming symptomatic with the tuberculosis that would kill him at twenty eight. Death, ever present, overshadowed his life and like a threatening eclipse looms, markedly, in his best work. “The Blue Hotel,” a crowning realization of the short story form, is a site for the expurgation of that relentless spectre, its alienated and adversarial Swede a personification of Crane’s own dissolution, forthwith to be ritualistically purged. Such sacrifice is shown to be psychosocially well founded, historical in long practice and supported by current theory as a means of restoring order to exigent chaos; here Crane in 1898, nearing his unruly end, implemented sacrificial victimization allegorically, with cardplaying rather than the casting of lots his aleatory selector, for the most vital personal reason.

scholarly journals Vulnerability and non-adherence to antiretroviral therapy among HIV patients, Minas Gerais State, Brazil

2008 ◽  
Vol 24 (11) ◽  
pp. 2603-2613 ◽  
Author(s):  
Palmira de Fátima Bonolo ◽  
Carla Jorge Machado ◽  
Cibele Comini César ◽  
Maria das Graças Braga Ceccato ◽  
Mark Drew Crosland Guimarães
Keyword(s):  
Antiretroviral Therapy ◽  
Illicit Drugs ◽  
Minas Gerais ◽  
Three Dimensions ◽  
Health Staff ◽  
Hiv Status ◽  
Hiv Patients ◽  
Personal Reason ◽  
Minas Gerais State ◽  
Grade Of Membership

The aim of the present study was to describe vulnerability profiles and to verify their association with non-adherence to antiretroviral therapy (ART) among 295 HIV-patients receiving their first prescription in two public-referral centers in Minas Gerais States, Brazil. The cumulative incidence of non-adherence was 36.9%. Three pure vulnerability profiles (lower, medium and higher) were identified based on the Grade of Membership method (GoM). Pure type patients of the "higher vulnerability" profile had, when compared to the overall sample, an increased probability of being younger, not understanding the need of ART, having a personal reason to be HIV-tested, not disclosing their HIV status, having more than one (non-regular) sexual partner, reporting use of alcohol, tobacco and illicit drugs, and having sex among men. Non-adherence to ART was statistically associated (p < 0.001) with this profile. Also, the heterogeneity of the sample was found to be high, since over 40% were mixed type. The implications are that health staff should be trained to develop strategies for incorporating risk-reduction interventions, bearing in mind the three dimensions of vulnerability and the diversity of those patients initiating antiretroviral therapy.

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