Exploring test retest reliability and longitudinal stability of digital biomarkers for Parkinson’s disease in the m-Power dataset (Preprint)

2020 ◽  
Author(s):  
Mehran Sahandi Far ◽  
Simon B. Eickhoff ◽  
Maria Goni ◽  
Juergen Dukart
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Volunteers ◽  
Intraclass Correlation ◽  
Smart Devices ◽  
Longitudinal Stability ◽  
Retest Reliability ◽  
Medication Effects ◽  
Test Retest Reliability ◽  
Digital Biomarkers

BACKGROUND Digital biomarkers (DB) as captured using sensors embedded in modern smart devices are a promising technology for home-based symptom monitoring in Parkinson’s disease (PD). Despite extensive application in recent studies test-retest reliability and longitudinal stability of DB has not been well addressed in this context. OBJECTIVE We utilized the large-scale m-Power dataset to establish the test-retest reliability and longitudinal stability of gait, balance, voice and tapping tasks in an unsupervised and self-administered daily life setting in PD patients and healthy volunteers. METHODS Intraclass Correlation Coefficients (ICC) were computed to estimate the test-retest reliability of features that also differentiate between PD and healthy volunteers. In addition, we tested for longitudinal stability of DB measures in PD and HC as well as for their sensitivity to PD medication effects. RESULTS Among the features differing between PD and HC, only few tapping and voice features had good to excellent test-retest reliabilities and medium to large effect sizes. All other features performed poorly in this respect. Only few features were sensitive to medication effects. The longitudinal analyses revealed significant alterations over time across a variety of features and in particular for the tapping task. CONCLUSIONS These results indicate the need for further development of more standardized, sensitive and reliable DB for application in self-administered remote studies in PD patients. Motivational, learning and other confounds may cause a variation in performance that needs to be considered in DB longitudinal applications. CLINICALTRIAL Not applicable

scholarly journals Exploring test retest reliability and longitudinal stability of digital biomarkers for Parkinson’s disease in the m-Power dataset

2020 ◽  
Author(s):  
Mehran Sahandi Far ◽  
Simon B. Eickhoff ◽  
María Goñi ◽  
Juergen Dukart
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Volunteers ◽  
Intraclass Correlation ◽  
Smart Devices ◽  
Longitudinal Stability ◽  
Retest Reliability ◽  
Medication Effects ◽  
Test Retest Reliability ◽  
Digital Biomarkers

AbstractBackgroundDigital biomarkers (DB) as captured using sensors embedded in modern smart devices are a promising technology for home-based symptom monitoring in Parkinson’s disease (PD).ObjectiveDespite extensive application in recent studies test-retest reliability and longitudinal stability of DB has not been well addressed in this context. We utilized the large-scale m-Power dataset to establish the test-retest reliability and longitudinal stability of gait, balance, voice and tapping tasks in an unsupervised and self-administered daily life setting in PD patients and healthy volunteers.MethodsIntraclass Correlation Coefficients (ICC) were computed to estimate the test-retest reliability of features that also differentiate between PD and healthy volunteers. In addition, we tested for longitudinal stability of DB measures in PD and HC as well as for their sensitivity to PD medication effects.ResultsAmong the features differing between PD and HC, only few tapping and voice features had good to excellent test-retest reliabilities and medium to large effect sizes. All other features performed poorly in this respect. Only few features were sensitive to medication effects. The longitudinal analyses revealed significant alterations over time across a variety of features and in particular for the tapping task.ConclusionsThese results indicate the need for further development of more standardized, sensitive and reliable DB for application in self-administered remote studies in PD patients. Motivational, learning and other confounds may cause a variation in performance that needs to be considered in DB longitudinal applications.

scholarly journals Translation, adaptation and validation of the Bulgarian version of the King’s Parkinson’s Disease Pain Scale

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Galina Stoyanova-Piroth ◽  
Ivan Milanov ◽  
Katerina Stambolieva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Intraclass Correlation ◽  
Pain Scale ◽  
Radicular Pain ◽  
Good Reliability ◽  
Retest Reliability ◽  
Nocturnal Pain ◽  
Test Retest Reliability

Abstract Background The purpose of the present study was to translate and cross-culturally adapt the King’s Parkinson’s Disease Pain Scale (KPPS) into Bulgarian and to investigate its psychometric properties in order to provide a validated Parkinson’s disease-specific pain instrument in Bulgarian language (KPPS-BG). Methods Translation into Bulgarian and a cultural adaptation were performed to obtain KPPS-BG. A total of 162 patients with idiopathic Parkinson’s disease were screened for pain using the complementary to the KPPS questionnaire – King’s Parkinson’s Disease Pain Questionnaire (KPPQ). KPPS-BG domain and total scores were calculated and internal consistency, construct validity and test-retest reliability were examined for 129 patients having one or more positive items in the KPPQ-BG. Results 79.6 % of the patients reported one or more types of pain. The most common type was musculoskeletal pain (83.7 %), followed by nocturnal pain (55.0 %), fluctuation-related pain (50.1 %), radicular pain (43.4 %), chronic pain (31.0 %), discoloration, edema/swelling (27.1 %) and, oro-facial pain (14.3 %). Mean KPPS-BG total score was 21.1 ± 17.3 SD. KPPS-BG showed a good reliability (Cronbach’s alpha 0.75). The test-retest reliability of the KPPS-BG was high and the intraclass correlation coefficient was 0.92, demonstrating а good repeatability. KPPS-BG total score was higher in patients with postural instability gait difficulty motor subtype, compared to tremor-dominant or indeterminate subtype. Significant positive correlations were found between KPPS-BG total score and modified H&Y, Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III. Conclusions The KPPS-BG constitutes a reliable, comprehensive and useful tool for pain assessment in native Bulgarian patients with Parkinson’s disease.

scholarly journals Translation, adaptation and validation of the Bulgarian version of the King’s Parkinson’s Disease Pain Scale

2021 ◽  
Author(s):  
Galina Stoyanova-Piroth ◽  
Ivan Milanov ◽  
Katerina Stambolieva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Intraclass Correlation ◽  
Pain Scale ◽  
Radicular Pain ◽  
Good Reliability ◽  
Retest Reliability ◽  
Nocturnal Pain ◽  
Test Retest Reliability

Abstract Introduction:The purpose of the present study was to translate and cross-culturally adapt the King's Parkinson's Disease Pain Scale (KPPS) into Bulgarian and to investigate its psychometric properties in order to provide a validated Parkinson’s disease-specific pain instrument in Bulgarian language (KPPS-BG).Methods:Translation into Bulgarian and a cultural adaptation were performed to obtain KPPS-BG. A total of 162 patients with idiopathic Parkinson’s disease were screened for pain using the complementary to the KPPS questionnaire-King’s Parkinson's Disease Pain Questionnaire (KPPQ). KPPS-BG domain and total scores were calculated and internal consistency, construct validity and test-retest reliability were examined for 129 patients having one or more positive items in the KPPQ-BG.Results:79.6% of the patients reported one or more types of pain. The most common type was musculoskeletal pain (83.7%), followed by nocturnal pain (55.0%), fluctuation-related pain (50.1%), radicular pain (43.4%), chronic pain (31.0%), discoloration, edema/swelling (27.1%) and, oro-facial pain (14.3%). Mean KPPS-BG total score was 21.1±17.3 SD. KPPS-BG showed a good reliability (Cronbach's alpha 0.75). The test-retest reliability of the KPPS-BG was high and the intraclass correlation coefficient was 0.92, demonstrating а good repeatability. KPPS-BG total score was higher in patients with postural instability gait difficulty motor subtype, compared to tremor-dominant or indeterminate subtype. Significant positive correlations were found between KPPS-BG total score and modified H&Y, Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III.Conclusion:The KPPS-BG constitutes a reliable, comprehensive and useful tool for pain assessment in native Bulgarian patients with Parkinson’s disease.

scholarly journals Cross-cultural adaptation of the Activities of Daily Living Questionnaire-Brazil in Parkinson’s disease

2021 ◽  
Author(s):  
Walter Luis Teixeira ALVES ◽  
Iza de FARIA-FORTINI ◽  
Ana Carolina Daher Ribas GALVÃO ◽  
Francisco Eduardo Costa CARDOSO ◽  
Paula Luciana SCALZO
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Intraclass Correlation ◽  
Altman Plot ◽  
Retest Reliability ◽  
Bland Altman Plot ◽  
Culturally Adapted ◽  
Test Retest Reliability

ABSTRACT Background: Culturally adapted measures to assess the performance of activities of daily living (ADL) in individuals with Parkinson’s disease (PD) are limited in Brazil. Objective: To adapt the ADL Questionnaire to the Brazilian culture and to analyze its reproducibility in individuals with PD. Methods: The ADL Questionnaire was translated and cross-culturally adapted to Brazilian Portuguese language. Reproducibility was analyzed using test-retest reliability and agreement values. The test-retest reliability of the individual items and total scores were calculated. The limits of agreement were verified using the Bland-Altman plot. The standard error of measurement (SEM) and the minimum detectable change (MDC) were calculated. Patients who were classified on a score of 1–4 on the modified Hoehn and Yahr scale were eligible. Results: No divergence was identified between the original and the adapted version, which demonstrated adequate semantic and conceptual equivalence. The Bland-Altman plot showed no systematic changes in the mean test-retest scores. The intraclass correlation coefficient (ICC) was 0.98 (95% confidence interval [95%CI] 0.93–0.99), and all individual items showed good levels of reliability (>0.60). The SEM (SEM%) and MDC (MDC%) values were 3.0 (6.75%) and 8.2 (18.7%), respectively. These values are within the recommended values. Conclusions: The ADL-Brazil Questionnaire is a reliable instrument to be used for clinical and research purposes to assess self-perceptions of ADL performance in individuals with PD.

scholarly journals Validity and Reliability of the Persian Version of Parkinson’s Disease Sleep Scale-2

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Mohammad Taghi Joghataei ◽  
Seyed-Mohammad Fereshtehnejad ◽  
Maryam Mehdizadeh ◽  
Sepideh Goudarzi ◽  
Sayed Amir Hasan Habibi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Internal Consistency ◽  
Convergent Validity ◽  
Intraclass Correlation ◽  
Depression Scale ◽  
Validity And Reliability ◽  
Retest Reliability ◽  
Persian Version ◽  
Test Retest Reliability

Objective. Sleep problems are nonmotor symptoms in Parkinson’s disease that should be carefully evaluated for better management and treatment. Parkinson’s Disease Sleep Scale (PDSS-2) is one of the most reliable tools for measuring sleep difficulties in people with Parkinson’s disease. This study investigated the psychometric properties of the Persian version of PDSS-2. Methods. Four hundred and fifty-six people with Parkinson’s disease with a mean age ±standard deviation of 60.7 ± 11.3 years were engaged in this study. Acceptability was assessed by floor and ceiling effects. Dimensionality was measured by exploratory factor analysis. The convergent validity of PDSS-2 with the Hospital Anxiety and Depression Scale (HADS) was assessed. Internal consistency and test-retest reliability were assessed with Cronbach’s alpha and intraclass correlation coefficient (ICC), respectively. Results. No noticeable ceiling and floor effect was detected. The dimensionality analysis showed three factors. A high correlation was obtained between PDSS-2 and HADS (anxiety subscale). Excellent internal consistency with α = 0.94, and good test-retest reliability with ICC = 0.89 were obtained. Conclusion. This study showed that the Persian version of Parkinson’s Disease Sleep Scale has acceptable validity and reliability for measuring sleep disturbances in people with Parkinson’s disease.

Construct validity and test-retest reliability of a free mobile application for spatio-temporal gait analysis in Parkinson’s disease patients

2020 ◽  
Vol 79 ◽  
pp. 86-91
Author(s):  
Sergio Clavijo-Buendía ◽  
Francisco Molina-Rueda ◽  
Patricia Martín-Casas ◽  
Paulina Ortega-Bastidas ◽  
Esther Monge-Pereira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Construct Validity ◽  
Gait Analysis ◽  
Mobile Application ◽  
Retest Reliability ◽  
Spatio Temporal ◽  
Test Retest Reliability

Test-retest reliability of stride length-cadence gait relationship in Parkinson’s disease

2019 ◽  
Vol 71 ◽  
pp. 177-180
Author(s):  
Mira Ambrus ◽  
Jose A. Sanchez ◽  
Jose A Sanchez Miguel ◽  
Fernandez del-Olmo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stride Length ◽  
Retest Reliability ◽  
Test Retest Reliability

scholarly journals Virtual Exam for Parkinson's Disease Enables Frequent and Reliable Measurements of Motor Function

2021 ◽  
Author(s):  
Maximilien Burq ◽  
Erin Rainaldi ◽  
King Chung Ho ◽  
Chen Chen ◽  
Bastiaan R Bloem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Stage ◽  
Real Life ◽  
Dropout Rate ◽  
Therapeutic Interventions ◽  
Retest Reliability ◽  
Time Sensitivity ◽  
Remote Measurements ◽  
Test Retest Reliability

Sensor-based remote monitoring could help us better track Parkinson's disease (PD) progression, and measure patients' response to putative disease-modifying therapeutic interventions. To be useful, the remotely-collected measurements should be valid, reliable and sensitive to change, and people with PD must engage with the technology. We developed a smartwatch-based active assessment that enables unsupervised measurement of motor signs of PD. 388 study participants with early-stage PD (Personalized Parkinson Project, 64% men, average age 63 years) wore a smartwatch for a median of 390 days, allowing for continuous passive monitoring. Participants performed unsupervised motor tasks both in the clinic (once) and remotely (twice weekly for one year). Dropout rate was 2% at the end of follow-up. Median wear-time was 21.1 hours/day, and 59% of per-protocol remote assessments were completed. In-clinic performance of the virtual exam verified that most participants correctly followed watch-based instructions. Analytical validation was established for in-clinic measurements, which showed moderate-to-strong correlations with consensus MDS-UPDRS Part III ratings for rest tremor (R=0.70), bradykinesia (R=-0.62), and gait (R=-0.46). Test-retest reliability of remote measurements, aggregated monthly, was good-to-excellent (ICC: 0.75 - 0.96). Remote measurements were sensitive to the known effects of dopaminergic medication (on vs off Cohen's d: 0.19 - 0.54). Of note, in-clinic assessments often did not reflect the patients' typical status at home. This demonstrates the feasibility of using smartwatch-based unsupervised active tests, and establishes the analytical validity of associated digital measurements. Weekly measurements can create a more complete picture of patient functioning by providing a real-life distribution of disease severity, as it fluctuates over time. Sensitivity to medication-induced change, together with the improvement in test-retest reliability from temporal aggregation implies that these methods could help reduce sample sizes needed to demonstrate a response to therapeutic intervention or disease progression.

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