scholarly journals Comparing the incidence of common adverse events of interest following influenza vaccination in the first season adjuvanted trivalent immunisation was introduced: English sentinel network annual report paper 2018/19 (Preprint)

2020 ◽  
Author(s):  
Simon de Lusignan ◽  
Ruby Tsang ◽  
Oluwafunmi Akinyemi ◽  
Jamie Lopez Bernal ◽  
Gayatri Amirthalingam ◽  
...  
Keyword(s):  
Adverse Events ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Reference Group ◽  
Case Series ◽  
European Medicines Agency ◽  
Seasonal Effect ◽  
Sentinel Network ◽  
Relative Incidence

BACKGROUND Vaccination is the most effective form of prevention of seasonal influenza; the UK has a national influenza vaccination programme to cover targeted population groups. Influenza vaccines are known to be associated with some common minor adverse events of interest (AEIs), but it is not known if the adjuvanted trivalent influenza vaccine (aTIV, first offered in the 2018/19 season) would be associated with more AEIs than other types of vaccines. OBJECTIVE To determine the Relative Incidence (RI) of AEIs following seasonal influenza vaccination, and compare RIs between aTIV, quadrivalent influenza vaccine (QIV) and live attenuated influenza vaccine (LAIV). METHODS We carried out a retrospective cohort study using computerised medical record data from the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network database. We extracted data on vaccine exposure and consultations for European Medicines Agency (EMA)-specified AEIs for the 2018/19 influenza season. We used a self-controlled case series design and computed relative incidence (RI) of AEIs following vaccination, and compared RI of AEIs associated with aTIV, QIV and LAIV. We also compared RI of AEIs for vaccinations that took place in a practice with those that took place elsewhere. RESULTS The majority of AEIs occurred within seven days following vaccination, with a seasonal effect observed. Using aTIV as the reference group, QIV was associated with a higher RI of AEIs (RI=1.46, 95% CI 1.41-1.52), whereas LAIV was associated with a lower RI of AEIs (RI=0.79, 95% CI 0.73-0.83). No effect of vaccination setting on RI of AEIs was observed. CONCLUSIONS Routine sentinel network data offer an opportunity to make comparisons between safety profiles of different vaccines. Evidence that supports the safety of newer types of vaccines may be reassuring for patients and could help improve uptake in the future.

scholarly journals Passive enhanced safety surveillance of GSK’s quadrivalent seasonal influenza vaccine in Belgium, Germany and Spain, an observational study: protocol for the 2018/2019 influenza season

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e028043 ◽  
Author(s):  
Gaël Dos Santos ◽  
Anne Yeakey ◽  
Vishvesh Shende ◽  
Katie Smith ◽  
Frederic Lin ◽  
...  
Keyword(s):  
Adverse Event ◽  
Adverse Events ◽  
Influenza Vaccine ◽  
Study Protocol ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Age Groups ◽  
European Medicines Agency ◽  
Case Report Form ◽  
Safety Surveillance

IntroductionThe European Medicines Agency requires Marketing Authorisation Holders providing seasonal influenza vaccines in Europe to conduct enhanced safety surveillance accounting for the different age groups based on the vaccine indication, in order to detect any potential increase of local and systemic adverse reactions early in an influenza season. To comply with this requirement, a multicountry European passive enhanced safety surveillance study has been set up to capture and assess adverse events occurring within 7 days following seasonal influenza vaccination. Here we share our surveillance protocol for the 2018/2019 influenza season.MethodsNine healthcare professionals (HCPs) in Belgium, Germany and Spain have been recruited for this study. Cumulatively, approximately 1000 vaccinees will be provided with customised adverse event recording cards to report adverse events experienced within 7 days following vaccination with GSK’s split-virion inactivated quadrivalent influenza vaccine. The cards are to be returned to the HCPs and the events encoded using an electronic case report form. Adverse event reporting rates will be analysed weekly and cumulatively, throughout the study period. Event rates will be described by country, age group and by influenza morbidity/mortality risk status of vaccinees (based on HCP assessment).Ethics and disseminationEthics committee approval was obtained for all participating sites prior to enrolment of the study participants. At the end of the study, each participating site will receive their data, and the outputs from the research will be made available to regulatory authorities. We intend to seek publication in peer-reviewed journals. GSK has posted a summary of the study protocol before the start of the study and results will be posted within 12 months of statistical analysis completion, in line with the National Institutes of Health recommendations.Trial registration numberNCT03688620.

scholarly journals Influenza vaccination during the coronavirus pandemic: intention to vaccinate among the at-risk population in the Central Catalonia Health Region (VAGCOVID)

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anna Bonet-Esteve ◽  
Raquel Muñoz-Miralles ◽  
Carla Gonzalez-Claramunt ◽  
Ana M Rufas ◽  
Xavier Pelegrin Cruz ◽  
...  
Keyword(s):  
At Risk ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Perceived Risk ◽  
Seasonal Influenza ◽  
Public Health Issue ◽  
Risk Population ◽  
Previous Season ◽  
The Individual

Abstract Background Influenza is a major public health issue, with the primary preventive measure being an annual influenza vaccination. Nevertheless, vaccination coverage among the at-risk population is low. Our understanding of the behaviour of the influenza virus during the SARS-CoV-2 coronavirus pandemic is limited, meaning influenza vaccination is still recommended for individuals at risk for severe complications due to influenza infection. The aim of the study is to determine the intention to vaccinate against seasonal influenza among the at-risk population in the 2020-21 campaign during the SARS-CoV-2 pandemic and to analyse the factors which influence such intention. Methods Cross-sectional telephone survey of adults (aged over 18) with risk factors in central Catalonia where the need for the Seasonal Influenza Vaccine (SIV) was recommended. Results A total of 434 participants responded to the survey, 43.3% of whom intended to be vaccinated against influenza for the 2020-2021 influenza season, 40.8% had no intention to be vaccinated and 15.9% were uncertain or did not express their opinion. The intention to get vaccinated against influenza is associated with having dependents, the individual’s perception of the risk of being infected with influenza and the perceived risk of transmission to dependents. It is also associated with age, whether the individual had received influenza vaccine the previous season or any other season before. The best predictors of the intention to vaccinate are the individual’s perception of the risk of catching influenza and whether the individual had been vaccinated in the previous season. Conclusions Intention to vaccinate can be a good predictor of individual behaviour in relation to vaccination. During the current SARS-CoV-2 pandemic many individuals are hesitant to influenza vaccination. In order to improve influenza vaccination coverage in people included in risk groups, it is necessary to promote educational actions, especially among those who express doubts.

scholarly journals Characteristics of Healthcare Workers Vaccinated against Influenza in the Era of COVID-19

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 695
Author(s):  
Giorgia Della Polla ◽  
Francesca Licata ◽  
Silvia Angelillo ◽  
Concetta Paola Pelullo ◽  
Aida Bianco ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Perceived Risk ◽  
Healthcare Workers ◽  
Seasonal Influenza ◽  
High Risk Group ◽  
High Coverage ◽  
Cross Sectional ◽  
Current Season ◽  
Study Results

Understanding the potential impact of COVID-19 on receiving influenza vaccination among healthcare workers (HCWs) is of utmost importance. The purposes of the present cross-sectional study were to describe the characteristics and to explore the predictors of receiving influenza vaccination among a large cohort of Italian HCWs in hospital settings. Information was collected through an anonymous questionnaire from December 2020 through January 2021. General and practice characteristics, perceived risk of seasonal influenza, attitudes towards efficacy and safety of influenza vaccination, and reasons behind the decision to be vaccinated against influenza were explored. Fewer than half (46.2%) of HCWs agreed that influenza is a serious illness and perceived the risk of getting infected with influenza, and concerns about the safety of the vaccination were significant positive predictors. Fewer than half of the respondents were not concerned at all about the efficacy (48.6%) and safety (49.8%) of influenza vaccination, and 51.9% reported that they have not received a seasonal influenza vaccine during the previous season. The most mentioned reason for receiving the influenza vaccine in the current season was that influenza and COVID-19 share some similar symptoms. Study results will aid policymakers in developing vaccination education programs, promotion of trust to address negative misconceptions, and to achieve future high coverage among this high-risk group.

scholarly journals Influenza vaccination in children primed with MF59®-adjuvanted or non-adjuvanted seasonal influenza vaccine

2015 ◽  
Vol 11 (8) ◽  
pp. 2102-2112 ◽  
Author(s):  
Timo Vesikari ◽  
Aino Forstén ◽  
Ashwani Arora ◽  
Theodore Tsai ◽  
Ralf Clemens
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccine

scholarly journals Influenza Vaccination Hesitancy among Healthcare Workers in South Al Batinah Governorate in Oman: A Cross-Sectional Study

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 661
Author(s):  
Salah T. Al Awaidy ◽  
Zayid K. Al Mayahi ◽  
Malak Kaddoura ◽  
Ozayr Mahomed ◽  
Nathalie Lahoud ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Healthcare Workers ◽  
Seasonal Influenza ◽  
General Medicine ◽  
Knowledge Score ◽  
Vaccine Uptake ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Increased Risk

Background: Seasonal influenza infections are a major cause of morbidity and mortality worldwide. Healthcare workers (HCWs) are an important target group for vaccination against influenza due to their increased risk of infection and their potential to transmit the infection to their patients, families and communities. The aim of this study was to assess the potential hesitancy and its associated factors towards influenza vaccination amongst HCWs in the South Al Batinah governorate in Oman. Methods: A cross-sectional survey of 390 HCWs with direct or indirect patient contact was conducted in May and June 2019 using a self-administered questionnaire. Associations between HCW characteristics and vaccination status were examined using bivariate and multivariate analyses to identify the likelihood of vaccination against seasonal influenza among HCWs. Results: Overall, 60% of HCWs were vaccinated in the 2018/2019 season; vaccine uptake among nurses was 52% and uptake was higher among women. Self-protection and protection of the community were the most cited reasons for vaccine acceptance, with side effects being the main reason for hesitancy. Vaccinated respondents had a higher mean knowledge score (7.18; standard deviation SD: 2.14) than unvaccinated respondents (6.30; SD: 2.2). Odds of vaccination were highest among respondents who believed influenza vaccine should be mandatory for HCWs (Odds ratio (OR): 2.04 [1.30–3.18]), those working in the general medicine, emergency medicine, or intensive care units (OR: 1.92 [1.20–3.10]), nurses and doctors (OR: 1.75 [1.09–2.79]) and those who believe that HCWs should receive an influenza vaccine (OR: 1.35 [1.07–2.77]). Conclusions: The study provides valuable insights into the enablers and barriers of influenza vaccination practices among HCWs and may inform interventions to increase acceptance of vaccination.

scholarly journals The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 663
Author(s):  
Amy C. Sherman ◽  
Lilin Lai ◽  
Mary Bower ◽  
Muktha S. Natrajan ◽  
Christopher Huerta ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Geometric Mean ◽  
Fold Change ◽  
Post Vaccination ◽  
Seasonal Influenza Vaccination ◽  
Vaccine Responses ◽  
Immune Factors ◽  
Antibody Secreting Cells

(1) Background: The influenza virus continues to cause significant annual morbidity and mortality. The overall efficacy of seasonal influenza vaccination is suboptimal, which is partly due to host immune factors. The effects of imprinting and repeated seasonal influenza vaccination were investigated to assess for immune factors and mechanisms that impact influenza vaccine responses. (2) Methods: Twenty participants were enrolled into a prospective pilot study based on birth cohort and seasonal influenza immunization history. Immunologic parameters were assessed over a six-month period after the seasonal influenza vaccine was administered. (3) Results: There was no significant imprinting effect, as measured by hemagglutination inhibition (HAI) fold change, HAI geometric mean titer (GMT) for Day 29 or Day 180 post-vaccination and antigen- specific antibody-secreting cells (ASC) for Day 8 post-vaccination. Individuals who had minimal prior seasonal influenza vaccination had a higher magnitude ASC response and a higher HAI fold change post-vaccination than individuals who were repeatedly vaccinated. (4) Conclusions: Repeated seasonal influenza vaccination resulted in a decreased fold change of the immune response, although individuals in this cohort tended to have high HAI titers at baseline that persisted after vaccination. Imprinting effects were not observed in this cohort. These host immune factors should be considered in the development of universal influenza vaccines. ClinicalTrials.gov Identifier: NCT03686514.

scholarly journals Seasonal Influenza Vaccination and Recommendation: The Difference between General Practitioners and Public Health Workers in China

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 265 ◽  
Author(s):  
Hongguo Rong ◽  
Xiaozhen Lai ◽  
Xiaochen Ma ◽  
Zhiyuan Hou ◽  
Shunping Li ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
General Practitioners ◽  
Seasonal Influenza ◽  
Health Workers ◽  
The Elderly ◽  
Vaccine Uptake ◽  
Knowledge And Attitudes ◽  
Public Health Workers

Seasonal influenza vaccination for healthcare workers (HCWs) is critical to the protection of HCWs and their patients. This study examined whether the separation of public health workers and general practitioners could affect the influenza vaccine uptake and recommendation behaviors among HCWs in China. A survey was conducted from August to October 2019, and HCWs from 10 provinces in China were recruited. A self-administered and anonymous questionnaire was used to assess HCWs’ demographic information, knowledge, and attitudes toward influenza vaccination, as well as vaccine uptake and recommendation behaviors. The primary outcome was HCWs’ vaccination and recommendation status of seasonal influenza vaccine. Multivariate logistic regression models were used to identify the influence factors of influenza vaccine uptake and recommendation among HCWs. Of the 1159 HCWs in this study, 25.3% were vaccinated against influenza in the previous season. “No need to get vaccinated” was the primary reason for both unvaccinated public health workers and general practitioners. Multivariate logistic regression showed that public health workers were more likely to get vaccinated against influenza (OR = 2.20, 95% CI 1.59–3.05) and recommend influenza vaccination to children (OR = 2.10, 95% CI 1.57–2.80) and the elderly (OR = 1.69, 95% CI 1.26–2.25) than general practitioners. Besides, the knowledge and perceived risk of influenza can give rise to HCWs’ vaccination and recommendation behaviors, and HCWs who got vaccinated in the past year were more likely to recommend it to children and the elderly in their work. The influenza vaccine coverage and recommendation among HCWs are still relatively low in China, especially for general practitioners. Further efforts are needed to improve the knowledge and attitudes toward influenza and influenza vaccination among HCWs, and coherent training on immunization for both public health workers and general practitioners might be effective in the face of separated public health and clinical services in China.

scholarly journals Influenza Vaccination Coverage among Registered Nurses in China during 2017-2018: an Internet Panel Survey (Preprint)

2019 ◽  
Author(s):  
Zhongjie Li ◽  
Jianxing Yu ◽  
Xiang Ren ◽  
Chuchu Ye ◽  
Keqing Tian ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Registered Nurses ◽  
Vaccination Coverage ◽  
Seasonal Influenza ◽  
Panel Survey ◽  
Vaccine Acceptance ◽  
Seasonal Influenza Vaccine ◽  
Factors Influencing ◽  
Principal Factors

BACKGROUND Influenza vaccination is recommended for nurses in China but is not mandatory or offered free of charge. Identifying factors that impact seasonal influenza vaccine acceptance among nurses in China may inform strategies to increase vaccination coverage in this high priority group. OBJECTIVE To determine influenza vaccination coverage and the principal factors influencing influenza vaccination among nurses in China. METHODS During March 22-April 1, 2018, we conducted an opt-in internet panel survey among registered nurses in China. Respondents were recruited from an internet-based training platform for nurses. We assessed influenza vaccination status and factors influencing influenza vaccine acceptance and refusal. RESULTS Among 22,888 nurses invited to participate, 4,706 responded, and 4,153 were valid respondents. Overall, 257 (6%) nurses reported receiving the seasonal influenza vaccine during the 2017/18 season. Vaccination coverage was highest among nurses working in Beijing (10%, P<.001) and nurses working in primary care (12%, P=.023). The top three reasons for not being vaccinated were lack of time (28%), not knowing where and when to get vaccinated (14%), and lack of confidence in the vaccine’s effectiveness (12%). Overall, 41% of nurses reported experiencing at least one episode of influenza-like illness (ILI) during the 2017/18 season; 87% of nurses kept working while sick, and 25% of nurses reported ever recommending influenza vaccination to patients. Compared with nurses who did not receive influenza vaccination in the 2017/18 season, nurses who received influenza vaccination were more likely to recommend influenza vaccination to patients (67% vs. 22%, P<.001). CONCLUSIONS Influenza vaccination coverage among nurses was low, and only a small proportion recommended influenza vaccine to patients. Our findings highlight the need for a multi-pronged strategy to increase influenza vaccination among nurses in China.

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