Does Outdoor Activity Reduce Migraine Episodes? Associations Between Migraine-related Online Searches and Mobility Trends during the COVID-19 Lockdown in the United States (Preprint)
BACKGROUND The effect of physical activity on migraines is unclear, with some studies showing that it triggers episodes and others finding that it is preventative. Google Trends, a tool that gauges population interest in online searches both geographically and longitudinally, has been previously used for disease surveillance, including migraines. However, the recent COVID-19 Mobility Community Reports, in combination with Google Trends data, offers a unique opportunity to explore migraine epidemiology using real-time, geographic trends in physical activity. OBJECTIVE Our aim is to examine the relationship between physical activity and migraine using a novel infodemiological approach by combining data from Google Trends and the COVID-19 Mobility Community Reports. METHODS We collected data from the COVID-19 Community Mobility Reports (CCMR), specifying a time period of March 1st- 15th, 2020. We were specifically interested in the mobility trends scores for 2 variables: 1) parks and 2) residential. To assess the impact of mobility on migraine-related online searches, we collected Google Trends data by entering “Migraine” for the time period between April 1st-15th, 2020, one month after our CCMR collection period. We then calculated the percent change in migraine Search Volume Index (SVI) using the same CCMR March 2020 dates as baseline. RESULTS The 15 states with the highest and lowest park mobility (PM) scores displayed an average percent change of -29% and -12% in migraine-related online searches, respectively (p=0.0209). Residential mobility (RM) scores, which signal stronger adherence to lockdown, was positively correlated with change in migraine SVI (r=+0.32, p=0.02). CONCLUSIONS In this study, we reveal that there is an association between increased visitation of outdoor areas (i.e., PM scores) and reduction in migraine-related online searches one month after. This is in line with the literature findings on the prophylactic impact of physical exercise on migraine attacks. Given that studies have linked time spent indoors to increased sedentary behavior, the association between residential mobility (RM) scores and increased frequency of migraine-related online searches (i.e. SVIs) was also expected. Google Trends and CCMR data may provide additional insights into the impact of physical activity on migraine and other neurological conditions.